-
公开(公告)号：US10047096B2
公开(公告)日：2018-08-14
申请号：US15529043
申请日：2015-11-23
发明人： Andreas Schall , Jürgen Klar , Mario Lobell , Hartmut Schirok , Joachim Telser , Steffen Müller , Dirk Brohm , Hans Briem , Hannah Jörißen , Joerg Keldenich , Michael Böttger , Georges Von Degenfeld , Thomas Schlange , Ulf Bömer , Niels Lindner , Hanna Eilken , Dmitrij Hristodorov , Pierre Wasnaire , Kersten Matthias Gericke , Lars Bärfacker
IPC分类号： A61K31/551 , C07D471/04 , C07D487/04 , A61K31/5513 , A61K39/395
摘要： The present application relates to novel (3-hydroxyphenyl)amino-substituted pyrido[2,3-b][1,5]benzodiazepin-5-one derivatives, to processes for preparation thereof, to the use thereof alone or in combination for treatment and/or prevention of diseases and to the use thereof for production of medicaments for treatment and/or prevention of diseases, especially of angiogenic disorders and hyperproliferative disorders in which neovascularization plays a role, for example ophthalmological disorders and cancers and tumours. Such treatments can be effected as monotherapy or else in combination with other medicaments or further therapeutic measures.
-
公开(公告)号：US09670202B2
公开(公告)日：2017-06-06
申请号：US14896426
申请日：2014-06-03
发明人： Hartmut Schirok , Volker Schulze , Dirk Kosemund , Hans Briem , Benjamin Bader , Ulf Bömer , Antje Margret Wengner , Gerhard Siemeister , Philip Lienau
IPC分类号： C07D471/04 , A61K31/496 , A61K31/5377 , A61K45/06
CPC分类号： C07D471/04 , A61K31/496 , A61K31/5377 , A61K45/06
摘要： The present invention relates to substituted triazolopyridine compounds of general formula (I); in which R1, R2, R3, R4, and R5 are as given in the description and in the claims, to methods of preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds, to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, as well as to intermediate compounds useful in the preparation of said compounds.
-
公开(公告)号：US09643953B2
公开(公告)日：2017-05-09
申请号：US14365895
申请日：2012-12-17
发明人： Marion Hitchcock , Anne Mengel , Anja Richter , Hans Briem , Knut Eis , Vera Pütter , Gerhard Siemeister , Stefan Prechtl , Amaury Ernesto Fernández-Montalván , Christian Stegmann , Simon Holton , Mark Jean Gnoth , Cornelia Preuβe
IPC分类号： C07D401/14 , A61K31/506 , C07D405/14
CPC分类号： C07D401/14 , A61K31/506 , C07D405/14
摘要： Compounds of formula (I) and their use as pharmaceutical.
-
公开(公告)号：US09549932B2
公开(公告)日：2017-01-24
申请号：US15159548
申请日：2016-05-19
发明人： Lars Wortmann , Ulrich Lücking , Julien Lefranc , Hans Briem , Franz Von Nussbaum , Benjamin Bader , Gerhard Siemeister , Wilhelm Bone , Philip Lienau , Dieter Moosmayer , Uwe Eberspächer , Hans Schick , Knut Eis , Marcus Koppitz , Antje Margret Wengner , Joanna Grudzinska-Goebel
IPC分类号： A61K31/5377 , A61K31/675 , A61K31/541 , A61K31/5386 , A61K45/06 , C07D471/04 , C07D491/22 , C07F9/6561 , C07D519/00 , A61K31/55
CPC分类号： A61K31/541 , A61K31/5377 , A61K31/5386 , A61K31/55 , A61K31/675 , A61K45/06 , C07D471/04 , C07D491/22 , C07D519/00 , C07F9/6561
摘要： The present invention relates to substituted 2-(morpholin-4-yl)-1,7-naphthyridine compounds of general formula (I) or (Ib), to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyperproliferative disease as a sole agent or in combination with other active ingredients.
摘要翻译： 制备所述化合物的方法，可用于制备所述化合物的中间体化合物，包含所述化合物的药物组合物和组合，以及所述化合物用于制备用于治疗或预防疾病，特别是过度增殖的药物组合物的用途 疾病作为唯一的代理或与其他活性成分组合。
-
公开(公告)号：US09416125B2
公开(公告)日：2016-08-16
申请号：US14400315
申请日：2013-05-08
发明人： Marion Hitchcock , Christoph-Stephan Hilger , Anne Mengel , Hans Briem , Simon Holton , Vera Pütter , Gerhard Siemeister , Stefan Prechtl , Amaury Ernesto Fernández-Montalván , Christian Stegmann , Cornelia Preuβe , Mark Jean Gnoth
IPC分类号： A61K31/506 , C07D401/14 , C07D405/14 , A61K31/5377 , A61K31/695 , A61K45/06 , C07D403/04 , C07F7/18
摘要： Compounds of formula (I), processes for their production and their use as Bub1 kinase inhibitors for the treatment of hyperproliferative diseases and/or disorders responsive to induction of cell death.
-
公开(公告)号：US10772893B2
公开(公告)日：2020-09-15
申请号：US15974536
申请日：2018-05-08
发明人： Lars Wortmann , Ulrich Lücking , Julien Lefranc , Hans Briem , Marcus Koppitz , Knut Eis , Franz Von Nussbaum , Benjamin Bader , Antje Margret Wengner , Gerhard Siemeister , Wilhelm Bone , Philip Lienau , Joanna Grudzinska-Goebel , Dieter Moosmayer , Uwe Eberspächer , Hans Schick
IPC分类号： C07D471/04 , C07D413/14 , A61K31/541 , A61K31/5377 , A61K31/5386 , A61K31/55 , A61K31/675 , A61K45/06 , C07D491/22 , C07D519/00 , C07F9/6561
摘要： The present invention relates to substituted 2-(morpholin-4-yl)-1,7-naphthyridine compounds of general formula (I) or (Ib), to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyperproliferative disease as a sole agent or in combination with other active ingredients.
-
![4H-pyrrolo[3,2-C]pyridin-4-one derivatives](/abs-image/US/2019/10/01/US10428063B2/abs.jpg.150x150.jpg)
公开(公告)号：US10428063B2
公开(公告)日：2019-10-01
申请号：US15547032
申请日：2016-01-25
发明人： Keith Graham , Ulrich Klar , Hans Briem , Volker Schulze , Gerhard Siemeister , Philip Lienau , René Tempel , Jozsef Bálint
IPC分类号： C07D471/04 , C07D405/14 , C07D401/12 , A61K31/437 , A61K31/444 , A61K45/06 , C07D519/00
摘要： Compound of formula (I), processes for their production and their use as pharmaceuticals.
-
公开(公告)号：US10350206B2
公开(公告)日：2019-07-16
申请号：US15512494
申请日：2015-09-17
发明人： Anne Mengel , Hans-Georg Lerchen , Manfred Möwes , Thomas Müller , Lars Bärfacker , Marion Hitchcock , Arwed Cleve , Joachim Kuhnke , Hans Briem , Gerhard Siemeister , Wilhelm Bone , Amaury Ernesto Fernandez-Montalvan , Jens Schröder , Ursula Mönning , Simon Holton
IPC分类号： A61K31/506 , C07D401/14 , C07D403/14
摘要： Compounds of formula (I) as defined herein and their use as pharmaceuticals.
-
公开(公告)号：US10308629B2
公开(公告)日：2019-06-04
申请号：US15750103
申请日：2016-08-01
发明人： Keith Graham , Ulrich Klar , Hans Briem , Gerhard Siemeister , Ursula Mönning
IPC分类号： A61K31/403 , A61K31/407 , A61K31/4439 , A61P35/00 , C07D401/04 , C07D401/14 , C07D487/14 , C07D405/14 , C07D403/04 , C07D409/14 , C07D417/14 , C07D471/04 , C07D491/056 , C07D487/04 , A61K45/06
摘要： Compounds of formula (I) as described herein, processes for their production and their use as pharmaceuticals.
-
公开(公告)号：US10227299B2
公开(公告)日：2019-03-12
申请号：US15737182
申请日：2016-06-14
发明人： Keith Graham , Ulrich Klar , Hans Briem , Gerhard Siemeister , Ursula Mönning , Jozsef Balint
IPC分类号： C07D209/40 , C07D401/04 , C07D401/14 , C07D403/04 , C07D405/14 , C07D409/14 , C07D417/14 , C07D471/04 , C07D491/056 , A61P35/04 , A61K31/403 , C07C327/46
摘要： Compounds of formula (I) as described herein processes for their production and their use as anti-cancer agents.
-
-
-
-
-
-
-
-
-
搜索结果
25 条记录 (耗时 0.037 秒)
