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公开(公告)号：US11315661B2
公开(公告)日：2022-04-26
申请号：US15886763
申请日：2018-02-01
Applicant: Becton, Dickinson and Company
Inventor： Jody Martin , Adam Wright , Paul Waterman , James Ghadiali
IPC: G16B50/00 , G06F16/248 , G06F16/2455 , G16B30/00 , G16B50/30
Abstract: Aspects of the present disclosure include systems for use in preparing an epitope tagged biomolecule reagent. A reagent preparatory apparatus for preparing the epitope tagged biomolecule reagent from an activated biomolecule and activated epitope tag is also described. Methods for communicating and receiving an epitope tagged biomolecule reagent request and preparing the subject epitope tagged biomolecule reagents are also provided.
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公开(公告)号：US20180232484A1
公开(公告)日：2018-08-16
申请号：US15886763
申请日：2018-02-01
Applicant: Becton, Dickinson and Company
Inventor： Jody Martin , Adam Wright , Paul Waterman , James Ghadiali
CPC classification number: G16B30/00 , G06F16/2455 , G06F16/248 , G16B50/30
Abstract: Aspects of the present disclosure include systems for use in preparing an epitope tagged biomolecule reagent. A reagent preparatory apparatus for preparing the epitope tagged biomolecule reagent from an activated biomolecule and activated epitope tag is also described. Methods for communicating and receiving an epitope tagged biomolecule reagent request and preparing the subject epitope tagged biomolecule reagents are also provided.
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3.发明授权公开(公告)号：US12153043B2
公开(公告)日：2024-11-26
申请号：US17184405
申请日：2021-02-24
Applicant: Becton, Dickinson and Company
Inventor： Jody Martin , James Ghadiali , Mirko Corselli , Adam Wright , Aaron Jacob Tyznik
IPC: G01N33/53
Abstract: Disclosed herein include methods, compositions, and kits suitable for spectral unmixing and compensation in multi-parameter flow cytometry. Disclosed herein include reagents which comprise two antibodies conjugated to one another to form a bispecific reagent (e.g., a bispecific probe). A first antibody can have affinity for a highly expressed antigen on the surface of a cell of interest and a second antibody can have affinity for each of the antibody-dye conjugates in a multi-parameter panel. There are provided, in some embodiments, methods of using the bispecific reagent to determine spillover, perform compensation, and generate a compensation matrix.
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4.发明申请公开(公告)号：US20210263019A1
公开(公告)日：2021-08-26
申请号：US17184405
申请日：2021-02-24
Applicant: Becton, Dickinson and Company
Inventor： Jody Martin , James Ghadiali , Mirko Corselli , Adam Wright , Aaron Jacob Tyznik
IPC: G01N33/53
Abstract: Disclosed herein include methods, compositions, and kits suitable for spectral unmixing and compensation in multi-parameter flow cytometry. Disclosed herein include reagents which comprise two antibodies conjugated to one another to form a bispecific reagent (e.g., a bispecific probe). A first antibody can have affinity for a highly expressed antigen on the surface of a cell of interest and a second antibody can have affinity for each of the antibody-dye conjugates in a multi-parameter panel. There are provided, in some embodiments, methods of using the bispecific reagent to determine spillover, perform compensation, and generate a compensation matrix.
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