公开(公告)号：US20220389021A1

公开(公告)日：2022-12-08

申请号：US17763720

申请日：2020-09-29

申请人： BEIGENE, LTD.

发明人： Qi JI ,  Chao YU ,  Ce WANG ,  Hanzi SUN

IPC分类号： C07D487/04

摘要： Disclosed herein are compounds that inhibit KRas G12C, pharmaceutical compositions, methods of preparation and uses thereof.

公开(公告)号：US20220289712A1

公开(公告)日：2022-09-15

申请号：US17636473

申请日：2020-08-20

申请人： BEIGENE, LTD.

发明人： Jing LI ,  Zhiwei WANG ,  Sanjia XU ,  Hanzi SUN ,  Ye LIU

IPC分类号： C07D401/14 ,  C07D401/04 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D491/048 ,  C07D491/052 ,  C07D495/04 ,  C07D498/04

摘要： Disclosed herein is an aminopyrazine compound of Formula (I), or a stereoisomer thereof, or a pharmaceutically acceptable salt thereof, and pharmaceutical compositions comprising thereof. Also disclosed is a method of treating HPK1 related disorders or diseases by using the compound disclosed herein.

公开(公告)号：US20210269433A1

公开(公告)日：2021-09-02

申请号：US17050581

申请日：2019-04-29

申请人： BEIGENE, LTD.

发明人： Yunhang GUO ,  Hai XUE ,  Zhiwei WANG ,  Hanzi SUN

IPC分类号： C07D471/04 ,  C07D519/00 ,  C07D405/14 ,  C07D403/12 ,  C07D471/14 ,  A61P35/00

摘要： Disclosed herein is a compound of Formula (I) for inhibiting Bcl-2 and treating disease associated with undesirable bcl-2 activity (Bcl-2 related diseases), a method of using the compounds disclosed herein for treating dysregulated apoptotic diseases including cancers and treating autoimmune disease, and a pharmaceutical composition comprising the same.

公开(公告)号：US20220402915A1

公开(公告)日：2022-12-22

申请号：US17750821

申请日：2022-05-23

申请人： BEIGENE, LTD.

发明人： Yunhang GUO ,  Hai XUE ,  Zhiwei WANG ,  Hanzi SUN

IPC分类号： C07D471/04 ,  A61P35/00 ,  C07D403/12 ,  C07D405/14 ,  C07D471/14 ,  C07D519/00

摘要： Disclosed herein is a compound of Formula (I) for inhibiting Bcl-2 and treating disease associated with undesirable bcl-2 activity (Bcl-2 related diseases), a method of using the compounds disclosed herein for treating dysregulated apoptotic diseases including cancers and treating autoimmune disease, and a pharmaceutical composition comprising the same.

公开(公告)号：US20210300936A1

公开(公告)日：2021-09-30

申请号：US17261359

申请日：2019-07-22

申请人： BEIGENE, LTD.

发明人： Guoliang ZHANG ,  Hanzi SUN ,  Changyou ZHOU

IPC分类号： C07D487/14

摘要： Disclosed herein is a pyrazolotriazolopyrimidine derivative or a stereoisomer thereof, or a pharmaceutically acceptable salt thereof useful as A2A receptor antagonist, and a pharmaceutical composition comprising the same. Also disclosed herein is a method of treating cancer using the pyrazolotriazolopyrimidine derivative or a stereoisomer thereof, or a pharmaceutically acceptable salt thereof as A2A receptor antagonist.

公开(公告)号：US20240262848A1

公开(公告)日：2024-08-08

申请号：US18597844

申请日：2024-03-06

申请人： BeiGene, Ltd.

发明人： Chao YU ,  Jie CHEN ,  Yichao BIAN ,  Xiaoyu LI ,  Hanzi SUN ,  Huaqing LIU ,  Ce WANG ,  Zhiwei WANG

IPC分类号： C07D519/00 ,  A61K31/519 ,  A61K31/553 ,  A61P35/00 ,  C07D498/22

CPC分类号： C07D519/00 ,  A61K31/519 ,  A61K31/553 ,  A61P35/00 ,  C07D498/22

摘要： Provided herein are compounds having the following structure:




wherein the substituents are as defined herein, compositions comprising an effective amount of a compound, and methods for modulating activity of KRAS G12D and/or G12V.