专利检索 ap:("BeiGene, Ltd.") AND inv:"Huaqing LIU" 第 1 页

1.

发明公开
INDOLINE COMPOUNDS AND DERIVATIVES AS EGFR INHIBITORS 审中-公开

公开(公告)号：US20230373960A1

公开(公告)日：2023-11-23

申请号：US18027665

申请日：2021-09-22

申请人： BeiGene, Ltd.

发明人： Bailin LEI , Huaqing LIU , Songzhe HAN , Zhiwei WANG

IPC分类号： C07D401/14 , C07D405/14 , C07D471/10 , C07D487/04 , C07D519/00 , A61P35/00

CPC分类号： C07D401/14 , C07D405/14 , C07D471/10 , C07D487/04 , C07D519/00 , A61P35/00

摘要： Disclosed herein are novel pharmaceutically active compounds and their preparation methods. The compounds inhibit mutant EGFR and are useful in the treatment of oncological diseases.

2.

发明公开
DEGRADATION OF (EGFR) BY CONJUGATION OF EGFR INHIBITORS WITH E3 LIGASE LIGAND AND METHODS OF USE 审中-公开

公开(公告)号：US20230265116A1

公开(公告)日：2023-08-24

申请号：US18016292

申请日：2021-07-15

申请人： BEIGENE, LTD.

发明人： Bailin LEI , Huaqing LIU , Songzhe HAN , Zhiwei WANG

IPC分类号： C07F9/6558 , C07D401/14 , C07D487/10

CPC分类号： C07F9/65583 , C07D401/14 , C07D487/10

摘要： Disclosed herein are novel bifunctional compounds formed by conjugating EGFR inhibitor moieties with E3 ligase ligand moieties, which function to recruit targeted proteins to E3 ubiquitin ligase for degradation, and methods of preparation and uses thereof.

3.

发明公开
DEGRADATION OF (EGFR) BY CONJUGATION OF EGFR INHIBITORS WITH E3 LIGASE LIGAND AND METHODS OF USE 审中-公开

公开(公告)号：US20230248834A1

公开(公告)日：2023-08-10

申请号：US18015561

申请日：2021-07-15

申请人： BEIGENE, LTD.

发明人： Bailin LEI , Huaqing LIU , Songzhe HAN , Zhiwei WANG

IPC分类号： A61K47/55 , A61K47/54

CPC分类号： A61K47/55 , A61K47/545

摘要： Disclosed herein are novel bifunctional compounds formed by conjugating EGFR inhibitor moieties with E3 ligase Ligand moieties, which function to recruit targeted proteins to E3 ubiquitin ligase for degradation, and methods of preparation and uses thereof.

4.

发明公开
HETEROCYCLIC COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH 审中-公开

公开(公告)号：US20240262848A1

公开(公告)日：2024-08-08

申请号：US18597844

申请日：2024-03-06

申请人： BeiGene, Ltd.

发明人： Chao YU , Jie CHEN , Yichao BIAN , Xiaoyu LI , Hanzi SUN , Huaqing LIU , Ce WANG , Zhiwei WANG

IPC分类号： C07D519/00 , A61K31/519 , A61K31/553 , A61P35/00 , C07D498/22

CPC分类号： C07D519/00 , A61K31/519 , A61K31/553 , A61P35/00 , C07D498/22

摘要： Provided herein are compounds having the following structure:

wherein the substituents are as defined herein, compositions comprising an effective amount of a compound, and methods for modulating activity of KRAS G12D and/or G12V.

5.

发明公开
BIFUNCTIONAL COMPOUNDS FOR DEGRADATION OF EGFR AND RELATED METHODS OF USE 审中-公开

公开(公告)号：US20240025902A1

公开(公告)日：2024-01-25

申请号：US18029227

申请日：2021-09-29

申请人： BeiGene, Ltd.

发明人： Bailin LEI , Huaqing LIU , Songzhe HAN , Zhiwei WANG

IPC分类号： C07D487/04 , C07D401/14 , C07D405/14

CPC分类号： C07D487/04 , C07D405/14 , C07D401/14

摘要： Disclosed herein are bifunctional compounds formed by conjugating EGFR inhibitor moieties with E3 ligase Ligand moieties, which function to recruit targeted proteins to E3 ubiquitin ligase for degradation of mutant EGFR kinase, and methods of preparation and uses thereof.