利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

42 条记录 (耗时 0.034 秒)

    Methods and compositions for treating cancer using proteasome inhibitors
    5.
    发明申请
    Methods and compositions for treating cancer using proteasome inhibitors 有权
    使用蛋白酶体抑制剂治疗癌症的方法和组合物

    公开(公告)号：US20050267037A1

    公开(公告)日：2005-12-01

    申请号：US11119473

    申请日：2005-04-29

    申请人： Kenneth Anderson ,  Teru Hideshima ,  Constantine Mitsiades ,  Nicholas Mitsiades

    发明人： Kenneth Anderson ,  Teru Hideshima ,  Constantine Mitsiades ,  Nicholas Mitsiades

    IPC分类号： A61K31/00 ,  A61K31/69 ,  A61K31/704 ,  A61K38/05 ,  A61K38/08

    CPC分类号： A61K31/69 ,  A61K31/195 ,  A61K31/198 ,  A61K31/573 ,  A61K31/704 ,  A61K38/05 ,  A61K45/06 ,  A61K2300/00

    摘要： The present invention relates to therapeutic compositions for treating cancer or preventing the growth of cancer cells, e.g., tumor growth, in a subject. The present invention also relates to methods for treating cancer, e.g., inhibiting tumor growth, in a subject who has become resistant to treatment, by administering to a subject an effective amount of a proteasome inhibitor and an effective amount of a therapeutic agent, e.g., a chemotherapeutic agent. The present invention further relates to methods for purging bone marrow, i.e., removing cancer cells from bone marrow, by exposing the bone marrow cells to a proteasome inhibitor and a therapeutic agent, e.g., a chemotherapeutic agent.

    摘要翻译： 本发明涉及用于治疗癌症或预防受试者中癌细胞生长，例如肿瘤生长的治疗组合物。 本发明还涉及通过向受试者施用有效量的蛋白酶体抑制剂和有效量的治疗剂来治疗已经变得耐受治疗的受试者的癌症的方法，例如抑制肿瘤生长，例如， 化疗剂。 本发明还涉及通过将骨髓细胞暴露于蛋白酶体抑制剂和治疗剂例如化学治疗剂来清除骨髓，即从骨髓中除去癌细胞的方法。

    Non-monetary bidding based on bidder-specific data
    6.
    发明授权
    Non-monetary bidding based on bidder-specific data 有权

    公开(公告)号：US10229452B2

    公开(公告)日：2019-03-12

    申请号：US14127645

    申请日：2013-06-22

    申请人： Jose K. Sia, Jr. ,  Kenneth Anderson ,  Anthony Salvador

    发明人： Jose K. Sia, Jr. ,  Kenneth Anderson ,  Anthony Salvador

    IPC分类号： G06Q30/00 ,  G06F17/30 ,  G06Q30/08

    摘要： Technologies are presented that provide automated non-monetary bidding based on bidder-specific data. A method includes receiving, from a bid acceptance server, an information request associated with a bidder; collecting and analyzing data regarding one or more data points associated with the bidder and requested in the information request; packaging analysis results into a bid; and providing the bid to the bid acceptance server. The data points may be limited based on input from the bidder. The data analyzed may include electronically-available data associated with the bidder. The method may be performed at the bid acceptance server, at a device of a bidder, or at a combination of the two. Submitted bids may be ranked by the bid acceptance server according to a given algorithm.

    Fail-safe implantable medical electrical lead
    7.
    发明授权
    Fail-safe implantable medical electrical lead 有权
    故障安全的可植入医用电线

    公开(公告)号：US08639358B2

    公开(公告)日：2014-01-28

    申请号：US13350403

    申请日：2012-01-13

    申请人： Kenneth Anderson

    发明人： Kenneth Anderson

    IPC分类号： A61N1/375

    CPC分类号： A61N1/0563 ,  A61N1/3931 ,  F04C2270/041

    摘要： An integrated bipolar implantable medical electrical lead, which may be employed by a cardiac defibrillator, has a single low voltage electrode and a single high voltage electrode and employs a relatively robust and fail-safe configuration of three conductors. Each of the three conductors extends within an individual lumen of a tri-lumen insulative body of the lead. First and second conductors of the three connect, in parallel, the low voltage electrode to a first contact of a connector terminal assembly of the lead, and a third conductor of the three connects the high voltage electrode to a second and a third contact of the connector terminal assembly. A configuration of the third conductor differs from that of the first and second conductors in order to make the third conductor more susceptible to fracture, relative to the first and second conductors, after many years of chronic implant under extreme loading conditions.

    摘要翻译： 可以由心脏除颤器使用的集成双极可植入医疗电引线具有单个低电压电极和单个高压电极，并采用三个导体相对鲁棒且故障安全的配置。 三根导体中的每一根在引线的三腔绝缘体的单个管腔内延伸。 三个第一和第二导体平行地将低压电极连接到引线的连接器端子组件的第一触点，并且三个的第三导体将高压电极连接到第二和第三触点的第二和第三触点 连接器端子组件。 第三导体的构造不同于第一和第二导体的构造，以便使第三导体相对于第一和第二导体在极端负载条件下长时间植入多年之后更容易断裂。

    CASING AND ROD HANDLER
    8.
    发明申请
    CASING AND ROD HANDLER 有权
    柜台操作

    公开(公告)号：US20100054895A1

    公开(公告)日：2010-03-04

    申请号：US12202718

    申请日：2008-09-02

    申请人： Vaughn J. Anderson ,  Kenneth Anderson

    发明人： Vaughn J. Anderson ,  Kenneth Anderson

    IPC分类号： E21B19/00

    CPC分类号： E21B19/00 ,  Y10S414/123

    摘要： A casing pipe and drill rod handler for joining the drill rod in a casing pipe. A pipe sled is provided on a drilling rig, the pipe sled comprising an elongated track with a cart slidably mounted on the track to accommodate the casing pipe. A drill rod guide is provided at one end of the track to guide a drill rod as it is positioned and then inserted into the casing pipe.

    摘要翻译： 用于将钻杆连接在套管中的套管和钻杆处理器。 管道滑雪板设置在钻机上，管道滑雪板包括细长的轨道，滑轨可滑动地安装在轨道上以容纳套管。 钻杆引导件设置在轨道的一端，以在钻杆定位时引导钻杆，然后插入套管中。

    Barrel system for a paintball marker
    9.
    发明申请
    Barrel system for a paintball marker 失效
    桶装系统

    公开(公告)号：US20060260597A1

    公开(公告)日：2006-11-23

    申请号：US11134762

    申请日：2005-05-23

    申请人： Kenneth Anderson

    发明人： Kenneth Anderson

    IPC分类号： F41A21/00 ,  F41B9/00

    CPC分类号： F41A21/02 ,  F41B11/00

    摘要： A barrel system for a paintball marker including a breach removably connected to the paintball marker and a composite front detachably connected to the breach. The composite front of the barrel system includes a hollow bore through which a paintball is propelled, a non-metallic inner layer surrounding the bore, and a non-metallic outer layer surrounding the inner layer. The non-metallic inner layer is preferably manufactured from a plurality of unidirectional graphite fibers embedded within an epoxy resin. The non-metallic outer layer is preferably manufactured from a plurality of graphite fibers that are woven together and embedded with an epoxy resin for surrounding and reinforcing the inner layer. The non-metallic inner layer of the composite front is smoothly and continuously tapered to cause the hollow bore to be tapered from a relatively narrow diameter to a relatively wide diameter in the direction of travel of the paintball.

    摘要翻译： 一种用于彩弹标记的桶系统，其包括可拆卸地连接到彩弹射击标记的突破部，以及可拆卸地连接到突破部的复合材料前部。 枪管系统的复合前部包括一个中空孔，弹珠穿过该中空孔，一个围绕该孔的非金属内层，以及围绕该内层的非金属外层。 非金属内层优选由嵌入在环氧树脂中的多个单向石墨纤维制成。 非金属外层优选由多个编织在一起并嵌有环氧树脂的石墨纤维制成，用于包围和加强内层。 复合材料前表面的非金属内层平滑且连续地变细，以使中空孔从彩弹的行进方向上从较窄的直径逐渐变细到相当宽的直径。

    Sweeper with sweeping elements
    10.
    发明授权
    Sweeper with sweeping elements 失效
    清扫车与清扫元素

    公开(公告)号：US08656544B1

    公开(公告)日：2014-02-25

    申请号：US13182086

    申请日：2011-07-13

    申请人： Kenneth Anderson

    发明人： Kenneth Anderson

    IPC分类号： A47L5/30

    CPC分类号： A47L11/22 ,  A47L11/4013 ,  A47L11/4041 ,  A47L11/4069

    摘要： The present invention is a sweeper incorporating multiple rotation elements mounted adjacently in an rotationally offset sequence on a common driven axle. Each rotation element comprises a central shaft support from which extends lightweight extension arms that have laterally elongated spatulate paddles at their ends. The extension arms may be curved so that in operation a terminal edge of each paddle lags the rest of the paddle surface in approaching and sweeping across the floor surface and is quite easily deflected upward from a floor surface.

    摘要翻译： 本发明是一种清扫机，其结合了多个旋转元件，其以相对于公共从动轴上的旋转偏移顺序相邻安装。 每个旋转元件包括中心轴支撑件，在该中心轴支撑件上延伸有在其端部具有横向细长的铲形桨的轻质延伸臂。 延伸臂可以是弯曲的，使得在操作中，每个桨叶的末端边缘在接近和扫掠地板表面时滞留桨叶表面的其余部分，并且非常容易地从地板表面向上偏转。