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1.发明授权公开(公告)号：US09446146B2
公开(公告)日：2016-09-20
申请号：US12342815
申请日：2008-12-23
申请人： Benjamin Daelken , Christoph Uherek , Kenneth Anderson , Teru Hideshima , Christoph Bruecher , Frank Osterroth , Silke Aigner , Matthias Germer
发明人： Benjamin Daelken , Christoph Uherek , Kenneth Anderson , Teru Hideshima , Christoph Bruecher , Frank Osterroth , Silke Aigner , Matthias Germer
CPC分类号： A61K47/48561 , A61K47/6803 , A61K47/6809 , A61K47/6849 , A61K47/6851 , A61K47/6867 , A61K2039/505 , C07K16/2896 , C07K2317/34 , C07K2317/73 , C07K2317/92
摘要： Disclosed are immunoconjugates having specificity for CD138 that diminish adhesion of CD138 expressing tumor cells to stroma cells and methods of using the same. This diminished adhesion renders the tumor cells not only susceptible to the immunoconjugate, but also to other agents, in particular cytotoxic agents.
摘要翻译： 公开了对CD138具有特异性的免疫缀合物，其降低表达CD138的肿瘤细胞与基质细胞的粘附性及其使用方法。 这种粘附性降低使得肿瘤细胞不仅对免疫缀合物敏感，而且对其它试剂，特别是细胞毒性剂也是敏感的。
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2.发明申请METHODS AND AGENTS FOR IMPROVING TARGETING OF CD138 EXPRESSING TUMOR CELLS 有权用于改善CD138表达肿瘤细胞靶向的方法和试剂公开(公告)号：US20090169570A1
公开(公告)日：2009-07-02
申请号：US12342815
申请日：2008-12-23
IPC分类号： A61K39/395 , A61P35/00
CPC分类号： A61K47/48561 , A61K47/6803 , A61K47/6809 , A61K47/6849 , A61K47/6851 , A61K47/6867 , A61K2039/505 , C07K16/2896 , C07K2317/34 , C07K2317/73 , C07K2317/92
摘要： Disclosed are immunoconjugates having specificity for CD138 that diminish adhesion of CD138 expressing tumor cells to stroma cells and methods of using the same. This diminished adhesion renders the tumor cells not only susceptible to the immunoconjugate, but also to other agents, in particular cytotoxic agents.
摘要翻译： 公开了对CD138具有特异性的免疫缀合物，其降低表达CD138的肿瘤细胞与基质细胞的粘附性及其使用方法。 这种粘附性降低使得肿瘤细胞不仅对免疫缀合物敏感，而且对其它试剂，特别是细胞毒性剂也是敏感的。
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公开(公告)号：US20060239909A1
公开(公告)日：2006-10-26
申请号：US11386959
申请日：2006-03-22
申请人： Kenneth Anderson , James Bradner , Edward Greenberg , Teru Hideshima , Nicholas Kwiatkowski , Ralph Mazitschek , Stuart Schreiber , Jared Shaw , Stephen Haggarty
发明人： Kenneth Anderson , James Bradner , Edward Greenberg , Teru Hideshima , Nicholas Kwiatkowski , Ralph Mazitschek , Stuart Schreiber , Jared Shaw , Stephen Haggarty
IPC分类号： A61K51/00 , A61K39/395 , A61K33/36
CPC分类号： A61K38/05 , A61K31/35 , A61K31/357 , A61K31/422 , A61K31/4965 , A61K31/69 , A61K38/50 , A61K45/06 , A61K49/0008 , G01N33/5011 , A61K2300/00
摘要： The invention relates to methods of treating protein degradation disorders, such cellular proliferative disorders (e.g., cancer) and protein deposition disorders (e.g., neurodegenerative disorders). The invention provides methods and pharmaceutical compositions for treating these diseases using aggresome inhibitors or combinations of aggresome inhibitors and proteasome inhibitors. The invention further relates to methods and pharmaceutical compositions for treating multiple myeloma. New HDAC/TDAC inhibitors and aggresome inhibitors are also provided as well as synthetic methodologies for preparing these compounds.
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公开(公告)号：US20060166947A1
公开(公告)日：2006-07-27
申请号：US11267031
申请日：2005-11-04
申请人： Kenneth Anderson , Teru Hideshima
发明人： Kenneth Anderson , Teru Hideshima
IPC分类号： A61K31/4745 , A61K31/407 , A61K31/403 , A61K31/192 , A61K31/60
CPC分类号： A61K31/192 , A61K31/403 , A61K31/407 , A61K31/4745 , A61K31/60
摘要： Provided herein are methods for treating refractory or resistant multiple myeloma in a subject using indole derivatives.
摘要翻译： 本文提供了使用吲哚衍生物治疗受治疗难治性或耐药性多发性骨髓瘤的方法。
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5.发明申请公开(公告)号：US20050267037A1
公开(公告)日：2005-12-01
申请号：US11119473
申请日：2005-04-29
IPC分类号： A61K31/00 , A61K31/69 , A61K31/704 , A61K38/05 , A61K38/08
CPC分类号： A61K31/69 , A61K31/195 , A61K31/198 , A61K31/573 , A61K31/704 , A61K38/05 , A61K45/06 , A61K2300/00
摘要： The present invention relates to therapeutic compositions for treating cancer or preventing the growth of cancer cells, e.g., tumor growth, in a subject. The present invention also relates to methods for treating cancer, e.g., inhibiting tumor growth, in a subject who has become resistant to treatment, by administering to a subject an effective amount of a proteasome inhibitor and an effective amount of a therapeutic agent, e.g., a chemotherapeutic agent. The present invention further relates to methods for purging bone marrow, i.e., removing cancer cells from bone marrow, by exposing the bone marrow cells to a proteasome inhibitor and a therapeutic agent, e.g., a chemotherapeutic agent.
摘要翻译： 本发明涉及用于治疗癌症或预防受试者中癌细胞生长，例如肿瘤生长的治疗组合物。 本发明还涉及通过向受试者施用有效量的蛋白酶体抑制剂和有效量的治疗剂来治疗已经变得耐受治疗的受试者的癌症的方法，例如抑制肿瘤生长，例如， 化疗剂。 本发明还涉及通过将骨髓细胞暴露于蛋白酶体抑制剂和治疗剂例如化学治疗剂来清除骨髓，即从骨髓中除去癌细胞的方法。
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6.发明授权公开(公告)号：US08026230B2
公开(公告)日：2011-09-27
申请号：US11119473
申请日：2005-04-29
CPC分类号： A61K31/69 , A61K31/195 , A61K31/198 , A61K31/573 , A61K31/704 , A61K38/05 , A61K45/06 , A61K2300/00
摘要： The present invention relates to therapeutic compositions for treating cancer or preventing the growth of cancer cells, e.g., tumor growth, in a subject. The present invention also relates to methods for treating cancer, e.g., inhibiting tumor growth, in a subject who has become resistant to treatment, by administering to a subject an effective amount of a proteasome inhibitor and an effective amount of a therapeutic agent, e.g., a chemotherapeutic agent. The present invention further relates to methods for purging bone marrow, i.e., removing cancer cells from bone marrow, by exposing the bone marrow cells to a proteasome inhibitor and a therapeutic agent, e.g., a chemotherapeutic agent.
摘要翻译： 本发明涉及用于治疗癌症或预防受试者中癌细胞生长，例如肿瘤生长的治疗组合物。 本发明还涉及通过向受试者施用有效量的蛋白酶体抑制剂和有效量的治疗剂来治疗已经变得耐受治疗的受试者的癌症的方法，例如抑制肿瘤生长，例如， 化疗剂。 本发明还涉及通过将骨髓细胞暴露于蛋白酶体抑制剂和治疗剂例如化学治疗剂来清除骨髓，即从骨髓中除去癌细胞的方法。
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7.发明申请公开(公告)号：US20120214757A1
公开(公告)日：2012-08-23
申请号：US13242209
申请日：2011-09-23
IPC分类号： A61K31/69 , A61K31/197 , A61P35/00 , A61K31/704
CPC分类号： A61K31/69 , A61K31/195 , A61K31/198 , A61K31/573 , A61K31/704 , A61K38/05 , A61K45/06 , A61K2300/00
摘要： The present invention relates to therapeutic compositions for treating cancer or preventing the growth of cancer cells, e.g., tumor growth, in a subject. The present invention also relates to methods for treating cancer, e.g., inhibiting tumor growth, in a subject who has become resistant to treatment, by administering to a subject an effective amount of a proteasome inhibitor and an effective amount of a therapeutic agent, e.g., a chemotherapeutic agent. The present invention further relates to methods for purging bone marrow, i.e., removing cancer cells from bone marrow, by exposing the bone marrow cells to a proteasome inhibitor and a therapeutic agent, e.g., a chemotherapeutic agent.
摘要翻译： 本发明涉及用于治疗癌症或预防受试者中癌细胞生长，例如肿瘤生长的治疗组合物。 本发明还涉及通过向受试者施用有效量的蛋白酶体抑制剂和有效量的治疗剂来治疗已经变得耐受治疗的受试者的癌症的方法，例如抑制肿瘤生长，例如， 化疗剂。 本发明还涉及通过将骨髓细胞暴露于蛋白酶体抑制剂和治疗剂例如化学治疗剂来清除骨髓，即从骨髓中除去癌细胞的方法。
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8.发明申请COMBINATIONS OF HISTONE DEACETYLASE INHIBITORS AND IMMUNOMODULATORY DRUGS 审中-公开组织脱乙酰壳多糖酶抑制剂和免疫调节剂的组合公开(公告)号：US20150105358A1
公开(公告)日：2015-04-16
申请号：US14508072
申请日：2014-10-07
IPC分类号： A61K31/505 , C07D401/04 , C07D239/42 , A61K31/454 , A61K31/573
CPC分类号： A61K31/505 , A61K31/454 , A61K31/573 , C07D239/42 , C07D401/04 , A61K2300/00
摘要： The invention relates to combinations comprising an HDAC inhibitor and an immunomodulatory drug for the treatment of multiple myeloma in a subject in need thereof. The combinations may, optionally, further comprise an anti-inflammatory agent, such as dexamethasone. Also provided herein are methods for treating multiple myeloma in a subject in need thereof comprising administering to the subject an effective amount of one of the above combinations.
摘要翻译： 本发明涉及包含HDAC抑制剂和用于在有需要的受试者中治疗多发性骨髓瘤的免疫调节药物的组合。 组合可以任选地进一步包含抗炎剂，例如地塞米松。 本文还提供了在有需要的受试者中治疗多发性骨髓瘤的方法，包括向受试者施用有效量的上述组合之一。
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公开(公告)号：US08999289B2
公开(公告)日：2015-04-07
申请号：US11386959
申请日：2006-03-22
申请人： Kenneth C. Anderson , James E. Bradner , Edward Franklin Greenberg , Teru Hideshima , Nicholas Paul Kwiatkowski , Ralph Mazitschek , Stuart L. Schreiber , Jared Shaw , Stephen J. Haggarty
发明人： Kenneth C. Anderson , James E. Bradner , Edward Franklin Greenberg , Teru Hideshima , Nicholas Paul Kwiatkowski , Ralph Mazitschek , Stuart L. Schreiber , Jared Shaw , Stephen J. Haggarty
IPC分类号： A61K51/00 , A61K31/357 , A61K31/35 , A61K31/4965 , A61K31/69 , A61K45/06 , A61K49/00 , G01N33/50 , A61K38/50
CPC分类号： A61K38/05 , A61K31/35 , A61K31/357 , A61K31/422 , A61K31/4965 , A61K31/69 , A61K38/50 , A61K45/06 , A61K49/0008 , G01N33/5011 , A61K2300/00
摘要： The invention relates to methods of treating protein degradation disorders, such cellular proliferative disorders (e.g., cancer) and protein deposition disorders (e.g., neurodegenerative disorders). The invention provides methods and pharmaceutical compositions for treating these diseases using aggresome inhibitors or combinations of aggresome inhibitors and proteasome inhibitors. The invention further relates to methods and pharmaceutical compositions for treating multiple myeloma. New HDAC/TDAC inhibitors and aggresome inhibitors are also provided as well as synthetic methodologies for preparing these compounds.
摘要翻译： 本发明涉及治疗蛋白质降解病症，细胞增殖性疾病（例如癌症）和蛋白质沉积病症（例如神经变性疾病）的方法。 本发明提供了使用聚集抑制剂或聚集抑制剂和蛋白酶体抑制剂的组合来治疗这些疾病的方法和药物组合物。 本发明还涉及用于治疗多发性骨髓瘤的方法和药物组合物。 还提供了新的HDAC / TDAC抑制剂和聚集抑制剂以及用于制备这些化合物的合成方法。
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10.发明授权公开(公告)号：US08685954B2
公开(公告)日：2014-04-01
申请号：US13242209
申请日：2011-09-23
CPC分类号： A61K31/69 , A61K31/195 , A61K31/198 , A61K31/573 , A61K31/704 , A61K38/05 , A61K45/06 , A61K2300/00
摘要： The present invention relates to therapeutic compositions for treating cancer or preventing the growth of cancer cells, e.g., tumor growth, in a subject. The present invention also relates to methods for treating cancer, e.g., inhibiting tumor growth, in a subject who has become resistant to treatment, by administering to a subject an effective amount of a proteasome inhibitor and an effective amount of a therapeutic agent, e.g., a chemotherapeutic agent. The present invention further relates to methods for purging bone marrow, i.e., removing cancer cells from bone marrow, by exposing the bone marrow cells to a proteasome inhibitor and a therapeutic agent, e.g., a chemotherapeutic agent.
摘要翻译： 本发明涉及用于治疗癌症或预防受试者中癌细胞生长，例如肿瘤生长的治疗组合物。 本发明还涉及通过向受试者施用有效量的蛋白酶体抑制剂和有效量的治疗剂来治疗已经变得耐受治疗的受试者的癌症的方法，例如抑制肿瘤生长，例如， 化疗剂。 本发明还涉及通过将骨髓细胞暴露于蛋白酶体抑制剂和治疗剂例如化学治疗剂来清除骨髓，即从骨髓中除去癌细胞的方法。
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