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公开(公告)号:US20080248095A1
公开(公告)日:2008-10-09
申请号:US12020364
申请日:2008-01-25
申请人: Beppino C. Giovanella , J. Vernon Knight , J. Clifford Waldrep , Nedezhda Koshkina , Brian Gilbert , Clyde W. Wellen
发明人: Beppino C. Giovanella , J. Vernon Knight , J. Clifford Waldrep , Nedezhda Koshkina , Brian Gilbert , Clyde W. Wellen
IPC分类号: A61K9/127 , A61K31/4375 , A61K38/21 , A61K31/03 , A61K31/52 , A61K31/175 , A61K31/7048
CPC分类号: A61K9/0078 , A61K9/127 , A61K31/03 , A61K31/175 , A61K31/337 , A61K31/4745 , A61K31/513 , A61K31/519 , A61K31/52 , A61K31/7048 , A61K38/21 , Y10S514/938
摘要: The small particle liposome aerosol compounds and methods of treatment of the present invention involve lipid- or water soluble anti-cancer drugs incorporated into liposomes. The liposomes are administered in aqueous dispersions from a jet nebulizer to the respiratory tract of an individual. Various anti-cancer drugs may be used, including 20-S-Camptothecin, 9-Nitro-camptothecin, 9-Amino-camptothecin, 10, 11-methylenedioxy-camptothecin and taxol or its derivatives. Administration of these drugs by inhalation provides faster and more efficient absorption of the anticancer drug than does intramuscular administration or oral administration.
摘要翻译: 小颗粒脂质体气溶胶化合物和本发明的治疗方法涉及掺入脂质体的脂质或水溶性抗癌药物。 脂质体在水分散体中从喷雾器喷射到个体的呼吸道。 可以使用各种抗癌药,包括20-S-喜树碱,9-硝基喜树碱,9-氨基喜树碱,10,11-亚甲二氧基喜树碱和紫杉醇或其衍生物。 通过吸入给药这些药物比肌肉内给药或口服给药提供更快更有效的抗癌药物吸收。