公开(公告)号：US06620910B1

公开(公告)日：2003-09-16

申请号：US09268578

申请日：1999-03-15

申请人： Bernard Calas ,  Gérard Grassy ,  Alain Chavanieu ,  Cyril Sarrauste de Menthiere ,  Pierre Renard ,  Bruno Pfeiffer ,  Dominique Manechez

发明人： Bernard Calas ,  Gérard Grassy ,  Alain Chavanieu ,  Cyril Sarrauste de Menthiere ,  Pierre Renard ,  Bruno Pfeiffer ,  Dominique Manechez

IPC分类号： A61K3816

CPC分类号： C07K14/605 ,  A61K38/00

摘要： Compound of formula (I): Z1-X1-X2-X3-Gly-Thr-Phe-Thr-Ser-X4-X5-Ser-X6-X7-X8  (I) wherein: Z1, substituent of the terminal amino group, represents hydrogen, alkyl or acyl, or arylcarbonyl, heteroarylcarbonyl, arylalkylcarbonyl, heteroarylcarbonyl, aryloxycarbonyl, arylalkoxycarbonyl or alkoxycarbonyl each of which is optionally substituted, Z2 (SEQ ID NO: 1), substituent of the terminal carbonyl group, represents hydroxy, alkoxy or optionally substituted amino, X1 to X14 each represents an amino acid residue having the D or L configuration as defined in the description, X15 represents a bond or an arginine residue (Arg). Medicinal products containing the same are useful as tGLP-1 agonists.

摘要翻译： 式（I）的化合物：其中：Z 1，末端氨基的取代基代表氢，烷基或酰基，或芳基羰基，杂芳基羰基，芳基烷基羰基，杂芳基羰基，芳氧基羰基，芳基烷氧基羰基或烷氧基羰基，其各自任选被取代，Z2（SEQ ID NO：1），末端羰基的取代基表示羟基，烷氧基或任选取代的氨基，X 1至X 14各自表示具有如说明书中所定义的D或L构型的氨基酸残基，X 15表示键或精氨酸残基 （Arg）。含有它们的药物可用作tGLP-1激动剂。