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    Peptide compounds analogues of the glucagon-like peptide-1 (7-37)
    1.
    发明授权
    Peptide compounds analogues of the glucagon-like peptide-1 (7-37) 失效
    胰高血糖素样肽-1（7-37）的肽化合物类似物

    公开(公告)号：US06620910B1

    公开(公告)日：2003-09-16

    申请号：US09268578

    申请日：1999-03-15

    申请人： Bernard Calas ,  Gérard Grassy ,  Alain Chavanieu ,  Cyril Sarrauste de Menthiere ,  Pierre Renard ,  Bruno Pfeiffer ,  Dominique Manechez

    发明人： Bernard Calas ,  Gérard Grassy ,  Alain Chavanieu ,  Cyril Sarrauste de Menthiere ,  Pierre Renard ,  Bruno Pfeiffer ,  Dominique Manechez

    IPC分类号： A61K3816

    CPC分类号： C07K14/605 ,  A61K38/00

    摘要： Compound of formula (I): Z1-X1-X2-X3-Gly-Thr-Phe-Thr-Ser-X4-X5-Ser-X6-X7-X8  (I) wherein: Z1, substituent of the terminal amino group, represents hydrogen, alkyl or acyl, or arylcarbonyl, heteroarylcarbonyl, arylalkylcarbonyl, heteroarylcarbonyl, aryloxycarbonyl, arylalkoxycarbonyl or alkoxycarbonyl each of which is optionally substituted, Z2 (SEQ ID NO: 1), substituent of the terminal carbonyl group, represents hydroxy, alkoxy or optionally substituted amino, X1 to X14 each represents an amino acid residue having the D or L configuration as defined in the description, X15 represents a bond or an arginine residue (Arg). Medicinal products containing the same are useful as tGLP-1 agonists.

    摘要翻译： 式（I）的化合物：其中：Z 1，末端氨基的取代基代表氢，烷基或酰基，或芳基羰基，杂芳基羰基，芳基烷基羰基，杂芳基羰基，芳氧基羰基，芳基烷氧基羰基或烷氧基羰基，其各自任选被取代，Z2（SEQ ID NO：1），末端羰基的取代基表示羟基，烷氧基或任选取代的氨基，X 1至X 14各自表示具有如说明书中所定义的D或L构型的氨基酸残基，X 15表示键或精氨酸残基 （Arg）。含有它们的药物可用作tGLP-1激动剂。

    Cytomodulating lipophilic peptides for modulating immune system activity and inhibiting inflammation
    3.
    发明授权
    Cytomodulating lipophilic peptides for modulating immune system activity and inhibiting inflammation 失效
    用于调节免疫系统活性和抑制炎症的细胞调节亲脂性肽

    公开(公告)号：US07267822B2

    公开(公告)日：2007-09-11

    申请号：US10780321

    申请日：2004-02-17

    申请人： Roland Buelow ,  Gèrard Grassy ,  Bernard Calas

    发明人： Roland Buelow ,  Gèrard Grassy ,  Bernard Calas

    IPC分类号： A61K38/00 ,  A61K38/03 ,  A61K47/00 ,  A61K47/10 ,  A61K47/18 ,  A61K31/045 ,  C07K7/06

    CPC分类号： C07K7/06 ,  A61K38/00

    摘要： Novel oligonucleotides comprising a sequence derived by a computer program are provided for inhibiting cytotoxic activity of lymphocytic cells, inhibiting production of inflammatory cytokines and inflammatory responses associated with those cytokines, inhibiting the activity of heme-containing enzymes and delaying the onset of an autoimmune disease. By combining the subject compositions with mixtures of cells comprising lymphocytic cells and cells which would otherwise activate the lymphocytic cells, lysis of the target cells can be substantially inhibited. The oligopeptides may be joined to a variety of other groups or compounds for varying the activity of the subject composition. The subject compositions may be administered by any convenient means to inhibit lymphocytic attack on tissue, particularly involved with xenogeneic or allogeneic transplants or to inhibit the production of inflammatory cytokines and inflammatory responses associated therewith. The subject compositions may also be used in the inhibition of the activity of heme-containing enzymes.

    摘要翻译： 提供包含通过计算机程序导出的序列的新型寡核苷酸用于抑制淋巴细胞的细胞毒活性，抑制炎症细胞因子的产生和与这些细胞因子相关的炎性反应，抑制含血红素酶的活性并延迟自身免疫性疾病的发作。 通过将主题组合物与包含淋巴细胞的细胞和否则将激活淋巴细胞的细胞的混合物组合，可以基本上抑制靶细胞的裂解。 寡肽可以连接到各种其它基团或化合物以改变主题组合物的活性。 主题组合物可以通过任何方便的手段来施用，以抑制对组织的淋巴细胞侵袭，特别是涉及异种或同种异体移植物或抑制炎性细胞因子的产生和与之相关的炎性反应。 主题组合物也可用于抑制含血红素酶的活性。

    Cytomodulating lipophilic peptides for modulating immune system activity and inhibiting inflammation
    5.
    发明授权
    Cytomodulating lipophilic peptides for modulating immune system activity and inhibiting inflammation 失效
    用于调节免疫系统活性和抑制炎症的细胞调节亲脂性肽

    公开(公告)号：US06696545B1

    公开(公告)日：2004-02-24

    申请号：US09028083

    申请日：1998-02-23

    申请人： Roland Buelow ,  Gèrard Grassy ,  Bernard Calas

    发明人： Roland Buelow ,  Gèrard Grassy ,  Bernard Calas

    IPC分类号： A61K3800

    CPC分类号： C07K7/06 ,  A61K38/00

    摘要： Novel oligopeptides comprising a sequence derived by a computer program are provided for use in inhibiting cytotoxic activity of lymphocytic cells, inhibiting the production of inflammatory cytokines and inflammatory responses associated with those cytokines, inhibiting the activity of heme-containing enzymes and delaying the onset of an autoimmune disease in a mammal at risk of developing the disease. By combining the subject compositions with mixtures of cells comprising lymphocytic cells and cells which would otherwise activate the lymphocytic cells, lysis of the target cells can be substantially inhibited. The oligopeptides may be joined to a wide variety of other groups or compounds for varying the activity of the subject compositions. The subject compositions may be administered by any convenient means to a host to inhibit lymphocytic attack on tissue, particularly involved with xenogeneic or allogeneic transplants or to inhibit the production of inflammatory cytokines and inflammatory responses associated therewith. The subject compositions may also be used in the inhibition of the activity of heme-containing enzymes.

    摘要翻译： 提供了包含通过计算机程序导出的序列的新型寡肽，用于抑制淋巴细胞的细胞毒性活性，抑制炎症细胞因子的产生和与那些细胞因子相关的炎症反应，抑制含血红素酶的活性并延迟起始 在发生该疾病风险的哺乳动物中的自身免疫性疾病。 通过将主题组合物与包含淋巴细胞的细胞和否则将激活淋巴细胞的细胞的混合物组合，可以基本上抑制靶细胞的裂解。 寡肽可以连接到各种各样的其它基团或化合物以改变主题组合物的活性。 主题组合物可以通过任何方便的方式施用于宿主以抑制对组织的淋巴细胞侵袭，特别是涉及异种或同种异体移植物或抑制与之相关的炎性细胞因子和炎性反应的产生。 主题组合物也可用于抑制含血红素酶的活性。

    Solid phase peptide synthesis using a polyacrylic support in aqueous solution
    6.
    发明授权
    Solid phase peptide synthesis using a polyacrylic support in aqueous solution 失效
    在水溶液中使用聚丙烯酸载体的固相肽合成

    公开(公告)号：US5175254A

    公开(公告)日：1992-12-29

    申请号：US766899

    申请日：1991-09-26

    申请人： Bernard Calas ,  Jean Mery ,  Hanitra Naharisoa ,  Michel Follet

    发明人： Bernard Calas ,  Jean Mery ,  Hanitra Naharisoa ,  Michel Follet

    IPC分类号： C07K1/04

    CPC分类号： C07K1/04

    摘要： This invention relates to solid phase peptide synthesis.Solid phase peptide synthesis is accomplished on polyacrylic resins (such as those described in EP 0 079 812 and EP 0 081 408 which correspond to U.S. Pat. Nos. 4,436,874 and 4,439,545 respectively) by a method which includes in the coupling protocol steps of washing the resin in water and/or aqueous solution(s).

    摘要翻译： 本发明涉及固相肽合成。 固相肽合成在聚丙烯酸树脂（例如分别对应于美国专利号4,436,874和4,439,545的EP 0 079 812和EP 0 081 408中描述的那些）中完成，方法包括在洗涤 在水和/或水溶液中的树脂。