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公开(公告)号：US07998483B2
公开(公告)日：2011-08-16
申请号：US12502274
申请日：2009-07-14
CPC分类号： C07K14/4748 , C12Q1/6886 , C12Q2600/154
摘要： The invention describes the LAGE-1 tumor associated gene, including fragments, allelic variants and splice variants thereof. Also included are polypeptides and fragments thereof encoded by such genes, and antibodies relating thereto. Methods and products also are provided for diagnosing and treating conditions characterized by expression of a LAGE-1 gene product.
摘要翻译： 本发明描述了LAGE-1肿瘤相关基因，包括片段，等位变体和剪接变体。 还包括由这些基因编码的多肽及其片段，以及与之相关的抗体。 还提供了用于诊断和治疗以LAGE-1基因产物表达为特征的病症的方法和产品。
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公开(公告)号：US20090274716A1
公开(公告)日：2009-11-05
申请号：US12502274
申请日：2009-07-14
CPC分类号： C07K14/4748 , C12Q1/6886 , C12Q2600/154
摘要： The invention describes the LAGE-1 tumor associated gene, including fragments, allelic variants and splice variants thereof. Also included are polypeptides and fragments thereof encoded by such genes, and antibodies relating thereto. Methods and products also are provided for diagnosing and treating conditions characterized by expression of a LAGE-1 gene product.
摘要翻译： 本发明描述了LAGE-1肿瘤相关基因，包括片段，等位变体和剪接变体。 还包括由这些基因编码的多肽及其片段，以及与之相关的抗体。 还提供了用于诊断和治疗以LAGE-1基因产物表达为特征的病症的方法和产品。
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公开(公告)号：US5811519A
公开(公告)日：1998-09-22
申请号：US791495
申请日：1997-01-27
IPC分类号： A61K38/00 , A61K39/00 , C07K14/47 , C07K14/74 , C12N15/12 , C07K1/00 , C07K14/00 , C07K17/00
CPC分类号： C07K14/70539 , A61K38/00 , A61K39/00 , A61K2039/51 , C07K14/4748
摘要： The invention describes the LL-1 tumor specific gene family, including fragments and biologically functional variants thereof. Also included are polypeptides and fragments thereof encoded by such genes, and antibodies relating thereto. Methods and products also are provided for diagnosing and treating conditions characterized by expression of a LL-1 gene product.
摘要翻译： 本发明描述了LL-1肿瘤特异性基因家族，包括其片段和生物功能变体。 还包括由这些基因编码的多肽及其片段，以及与之相关的抗体。 还提供了用于诊断和治疗以LL-1基因产物表达为特征的病症的方法和产品。
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公开(公告)号：US06794131B1
公开(公告)日：2004-09-21
申请号：US09341829
申请日：1999-10-18
IPC分类号： C12Q168
CPC分类号： C07K14/4748 , C12Q1/6886 , C12Q2600/154
摘要： The invention describes the LAGE-1 tumor associated gene, including fragments, allelic variants and splice variants thereof. Also included are polypeptides and fragments thereof encoded by such genes, antibodies relating thereto. Methods and products also are provided for diagnosing and treating conditions characterized by expression of a LAGE-1 gene product.
摘要翻译： 本发明描述了LAGE-1肿瘤相关基因，包括片段，等位变体和剪接变体。 还包括由这些基因编码的多肽及其片段，与之相关的抗体。 还提供了用于诊断和治疗以LAGE-1基因产物表达为特征的病症的方法和产品。
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公开(公告)号：US07563870B2
公开(公告)日：2009-07-21
申请号：US10877373
申请日：2004-06-25
IPC分类号： C07K14/00
CPC分类号： C07K14/4748 , C12Q1/6886 , C12Q2600/154
摘要： The invention describes the LAGE-1 tumor associated gene, including fragments, allelic variants and splice variants thereof. Also included are polypeptides and fragments thereof encoded by such genes, and antibodies relating thereto. Methods and products also are provided for diagnosing and treating conditions characterized by expression of a LAGE-1 gene product.
摘要翻译： 本发明描述了LAGE-1肿瘤相关基因，包括片段，等位变体和剪接变体。 还包括由这些基因编码的多肽及其片段，以及与之相关的抗体。 还提供了用于诊断和治疗以LAGE-1基因产物表达为特征的病症的方法和产品。
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6.发明授权Isolated nucleic acid molecules useful in determining expression of a tumor rejection antigen precursor 失效用于确定肿瘤排斥抗原前体表达的分离的核酸分子
公开(公告)号：US5612201A
公开(公告)日：1997-03-18
申请号：US299849
申请日：1994-09-01
申请人： Etienne De Plaen , Thierry Boon-Falleur , Bernard Lethe , Jean-Pierre Szikora , Charles De Smet , Patrick Chomez
发明人： Etienne De Plaen , Thierry Boon-Falleur , Bernard Lethe , Jean-Pierre Szikora , Charles De Smet , Patrick Chomez
IPC分类号： A61K38/00 , A61K39/00 , C07K14/47 , C07K16/30 , C12Q1/68 , C12P19/34 , C07H21/02 , C07H21/04
CPC分类号： C07K16/30 , C07K14/4748 , C12Q1/6886 , A61K38/00 , A61K39/00 , C12Q2600/156 , C12Q2600/158 , C12Q2600/172
摘要： The invention relates to nucleic acid molecules which are useful in determining expression of the family of molecules known as the MAGE tumor rejection antigen precursors. These nucleic acid are molecules useful as diagnostic aids for determining whether or not an individual has cancer. Methods using these molecules are also described.
摘要翻译： 本发明涉及可用于确定被称为MAGE肿瘤排斥抗原前体的分子家族的表达的核酸分子。 这些核酸是用作确定个体是否患有癌症的诊断辅助物的分子。 还描述了使用这些分子的方法。
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7.发明授权
公开(公告)号：US5997872A
公开(公告)日：1999-12-07
申请号：US993118
申请日：1997-12-17
IPC分类号： C12N15/09 , A61P35/00 , C07K14/47 , C07K14/82 , C12N5/10 , C12N15/12 , C12Q1/02 , C12Q1/68 , G01N33/569 , A61K39/00 , A61K38/00 , C07H21/04 , G01N33/574
CPC分类号： G01N33/56977 , C07K14/4748
摘要： The invention relates to an isolated DNA sequence which codes for an antigen expressed by tumor cells which maybe recognized by cytotoxic T cells, leading to lysis of the tumor cells which express it. This invention also relates to vectors which are designed to encode the antigen expressed by tumor cells and also to cells transfected by the DNA sequence or vectors which comprise the DNA sequence. Various therapeutic and diagnostic uses arising out of the properties of the DNA and the antigen for which it codes are also part of this invention.
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公开(公告)号：US07022819B2
公开(公告)日：2006-04-04
申请号：US10160237
申请日：2002-06-04
IPC分类号： C07K14/00
CPC分类号： G01N33/56977 , C07K14/4748
摘要： The invention relates to isolated nucleic acid molecules which code for antigens expressed by tumor cells which maybe recognized by cytotoxic T cells, leading to lysis of the tumor cells which express it. This invention also relates to vectors which are designed to encode the antigen expressed by tumor cells and also to cells transfected by the nucleic acid molecules or vectors which comprise the nucleic acid molecules. Various therapeutic and diagnostic uses arising out of the properties of the nucleic acid molecules and the antigens for which these code are also part of this invention.
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9.发明授权Isolated nucleic acid molecule coding for tumor rejection antigen precursor MAGE-C1 and uses thereof 失效编码肿瘤排斥抗原前体MAGE-C1的分离的核酸分子及其用途
公开(公告)号：US6027924A
公开(公告)日：2000-02-22
申请号：US845528
申请日：1997-04-25
IPC分类号： C12N15/09 , A61P35/00 , C07K14/47 , C07K14/82 , C12N5/10 , C12N15/12 , C12Q1/02 , C12Q1/68 , G01N33/569 , C12P19/24
CPC分类号： G01N33/56977 , C07K14/4748
摘要： The invention relates to an isolated DNA sequence which codes for an antigen expressed by tumor cells which maybe recognized by cytotoxic T cells, leading to lysis of the tumor cells which express it. This invention also relates to vectors which are designed to encode the antigen expressed by tumor cells and also to cells transfected by the DNA sequence or vectors which comprise the DNA sequence. Various therapeutic and diagnostic uses arising out of the properties of the DNA and the antigen for which it codes are also part of this invention.
摘要翻译： 本发明涉及编码由细胞毒性T细胞识别的肿瘤细胞表达的抗原的分离的DNA序列，导致表达其的肿瘤细胞的裂解。 本发明还涉及设计用于编码由肿瘤细胞表达的抗原以及由DNA序列转染的细胞或包含DNA序列的载体的载体。 由DNA及其编码的抗原的性质引起的各种治疗和诊断用途也是本发明的一部分。
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10.发明授权Isolated nucleic acid molecule coding for tumor rejection antigen precursors MAGE-C1 and MAGE-C2 and uses thereof 失效编码肿瘤排斥抗原前体MAGE-C1和MAGE-C2的分离的核酸分子及其用途公开(公告)号：US06475783B1
公开(公告)日：2002-11-05
申请号：US09066281
申请日：1998-04-24
IPC分类号： C12M1585
CPC分类号： G01N33/56977 , C07K14/4748
摘要： The invention relates to isolated nucleic acid molecules which code for antigens expressed by tumor cells which maybe recognized by cytotoxic T cells, leading to lysis of the tumor cells which express it. This invention also relates to vectors which are designed to encode the antigen expressed by tumor cells and also to cells transfected by the nucleic acid molecules or vectors which comprise the nucleic acid molecules. Various therapeutic and diagnostic uses arising out of the properties of the nucleic acid molecules and the antigens for which these code are also part of this invention.
摘要翻译： 本发明涉及分离的核酸分子，其编码由细胞毒性T细胞识别的肿瘤细胞表达的抗原，导致表达它的肿瘤细胞的裂解。 本发明还涉及被设计用于编码由肿瘤细胞表达的抗原以及由核酸分子转染的细胞或包含核酸分子的载体的载体。 由于这些代码也是本发明的一部分的核酸分子和抗原的性质引起的各种治疗和诊断用途。
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