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公开(公告)号：US07998483B2
公开(公告)日：2011-08-16
申请号：US12502274
申请日：2009-07-14
CPC分类号： C07K14/4748 , C12Q1/6886 , C12Q2600/154
摘要： The invention describes the LAGE-1 tumor associated gene, including fragments, allelic variants and splice variants thereof. Also included are polypeptides and fragments thereof encoded by such genes, and antibodies relating thereto. Methods and products also are provided for diagnosing and treating conditions characterized by expression of a LAGE-1 gene product.
摘要翻译： 本发明描述了LAGE-1肿瘤相关基因，包括片段，等位变体和剪接变体。 还包括由这些基因编码的多肽及其片段，以及与之相关的抗体。 还提供了用于诊断和治疗以LAGE-1基因产物表达为特征的病症的方法和产品。
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公开(公告)号：US5811519A
公开(公告)日：1998-09-22
申请号：US791495
申请日：1997-01-27
IPC分类号： A61K38/00 , A61K39/00 , C07K14/47 , C07K14/74 , C12N15/12 , C07K1/00 , C07K14/00 , C07K17/00
CPC分类号： C07K14/70539 , A61K38/00 , A61K39/00 , A61K2039/51 , C07K14/4748
摘要： The invention describes the LL-1 tumor specific gene family, including fragments and biologically functional variants thereof. Also included are polypeptides and fragments thereof encoded by such genes, and antibodies relating thereto. Methods and products also are provided for diagnosing and treating conditions characterized by expression of a LL-1 gene product.
摘要翻译： 本发明描述了LL-1肿瘤特异性基因家族，包括其片段和生物功能变体。 还包括由这些基因编码的多肽及其片段，以及与之相关的抗体。 还提供了用于诊断和治疗以LL-1基因产物表达为特征的病症的方法和产品。
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公开(公告)号：US20090274716A1
公开(公告)日：2009-11-05
申请号：US12502274
申请日：2009-07-14
CPC分类号： C07K14/4748 , C12Q1/6886 , C12Q2600/154
摘要： The invention describes the LAGE-1 tumor associated gene, including fragments, allelic variants and splice variants thereof. Also included are polypeptides and fragments thereof encoded by such genes, and antibodies relating thereto. Methods and products also are provided for diagnosing and treating conditions characterized by expression of a LAGE-1 gene product.
摘要翻译： 本发明描述了LAGE-1肿瘤相关基因，包括片段，等位变体和剪接变体。 还包括由这些基因编码的多肽及其片段，以及与之相关的抗体。 还提供了用于诊断和治疗以LAGE-1基因产物表达为特征的病症的方法和产品。
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公开(公告)号：US06794131B1
公开(公告)日：2004-09-21
申请号：US09341829
申请日：1999-10-18
IPC分类号： C12Q168
CPC分类号： C07K14/4748 , C12Q1/6886 , C12Q2600/154
摘要： The invention describes the LAGE-1 tumor associated gene, including fragments, allelic variants and splice variants thereof. Also included are polypeptides and fragments thereof encoded by such genes, antibodies relating thereto. Methods and products also are provided for diagnosing and treating conditions characterized by expression of a LAGE-1 gene product.
摘要翻译： 本发明描述了LAGE-1肿瘤相关基因，包括片段，等位变体和剪接变体。 还包括由这些基因编码的多肽及其片段，与之相关的抗体。 还提供了用于诊断和治疗以LAGE-1基因产物表达为特征的病症的方法和产品。
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公开(公告)号：US07563870B2
公开(公告)日：2009-07-21
申请号：US10877373
申请日：2004-06-25
IPC分类号： C07K14/00
CPC分类号： C07K14/4748 , C12Q1/6886 , C12Q2600/154
摘要： The invention describes the LAGE-1 tumor associated gene, including fragments, allelic variants and splice variants thereof. Also included are polypeptides and fragments thereof encoded by such genes, and antibodies relating thereto. Methods and products also are provided for diagnosing and treating conditions characterized by expression of a LAGE-1 gene product.
摘要翻译： 本发明描述了LAGE-1肿瘤相关基因，包括片段，等位变体和剪接变体。 还包括由这些基因编码的多肽及其片段，以及与之相关的抗体。 还提供了用于诊断和治疗以LAGE-1基因产物表达为特征的病症的方法和产品。
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公开(公告)号：US07785881B2
公开(公告)日：2010-08-31
申请号：US12011726
申请日：2008-01-29
IPC分类号： C12N15/86
CPC分类号： C07K14/4748 , A61K38/00 , A61K2039/57
摘要： This invention relates to isolated peptides derived from MAGE-C2, nucleic acid molecules that encode MAGE-C2 and the isolated peptides derived from MAGE-C2, expression vectors comprising the nucleic acid molecules, host cells transformed or transfected with the nucleic acid molecules or the expression vectors, and to tetramers comprising the peptides, HLA molecules, β2 microglobulin and a first and second binding partner. This invention also relates to methods for using the peptides, nucleic acid molecules, expression vectors, tetramers and complexes of this invention as well as to cytolytic T cells which recognize the peptides in complex with an HLA molecule.
摘要翻译： 本发明涉及衍生自MAGE-C2的分离的肽，编码MAGE-C2的核酸分子和来自MAGE-C2的分离的肽，包含核酸分子的表达载体，用核酸分子转化或转染的宿主细胞 表达载体以及包含肽，HLA分子，2微球蛋白和第一和第二结合配偶体的四聚体。 本发明还涉及使用本发明的肽，核酸分子，表达载体，四聚体和复合物以及识别与HLA分子复合的肽的细胞溶解性T细胞的方法。
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公开(公告)号：US20080311652A1
公开(公告)日：2008-12-18
申请号：US12011726
申请日：2008-01-29
CPC分类号： C07K14/4748 , A61K38/00 , A61K2039/57
摘要： This invention relates to isolated peptides derived from MAGE-C2, nucleic acid molecules that encode MAGE-C2 and the isolated peptides derived from MAGE-C2, expression vectors comprising the nucleic acid molecules, host cells transformed or transfected with the nucleic acid molecules or the expression vectors, and to tetramers comprising the peptides, HLA molecules, β2 microglobulin and a first and second binding partner. This invention also relates to methods for using the peptides, nucleic acid molecules, expression vectors, tetramers and complexes of this invention as well as to cytolytic T cells which recognize the peptides in complex with an HLA molecule.
摘要翻译： 本发明涉及衍生自MAGE-C2的分离的肽，编码MAGE-C2的核酸分子和来自MAGE-C2的分离的肽，包含核酸分子的表达载体，用核酸分子转化或转染的宿主细胞 表达载体和包含肽，HLA分子，β2微球蛋白和第一和第二结合配偶体的四聚体。 本发明还涉及使用本发明的肽，核酸分子，表达载体，四聚体和复合物以及识别与HLA分子复合的肽的细胞溶解性T细胞的方法。
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公开(公告)号：US07348007B2
公开(公告)日：2008-03-25
申请号：US11044051
申请日：2005-01-28
IPC分类号： A61K39/00
CPC分类号： C07K14/4748 , A61K38/00 , A61K2039/57
摘要： This invention relates to isolated peptides derived from MAGE-C2, nucleic acid molecules that encode MAGE-C2 and the isolated peptides derived from MAGE-C2, expression vectors comprising the nucleic acid molecules, host cells transformed or transfected with the nucleic acid molecules or the expression vectors, and to tetramers comprising the peptides, HLA molecules, β2 microglobulin and a first and second binding partner. This invention also relates to methods for using the peptides, nucleic acid molecules, expression vectors, tetramers and complexes of this invention as well as to cytolytic T cells which recognize the peptides in complex with an HLA molecule.
摘要翻译： 本发明涉及衍生自MAGE-C2的分离的肽，编码MAGE-C2的核酸分子和来自MAGE-C2的分离的肽，包含核酸分子的表达载体，用核酸分子转化或转染的宿主细胞 表达载体和包含肽，HLA分子，β2微球蛋白和第一和第二结合配偶体的四聚体。 本发明还涉及使用本发明的肽，核酸分子，表达载体，四聚体和复合物以及识别与HLA分子复合的肽的细胞溶解性T细胞的方法。
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公开(公告)号：US20050255553A1
公开(公告)日：2005-11-17
申请号：US11044051
申请日：2005-01-28
CPC分类号： C07K14/4748 , A61K38/00 , A61K2039/57
摘要： This invention relates to isolated peptides derived from MAGE-C2, nucleic acid molecules that encode MAGE-C2 and the isolated peptides derived from MAGE-C2, expression vectors comprising the nucleic acid molecules, host cells transformed or transfected with the nucleic acid molecules or the expression vectors, and to tetramers comprising the peptides, HLA molecules, β2 microglobulin and a first and second binding partner. This invention also relates to methods for using the peptides, nucleic acid molecules, expression vectors, tetramers and complexes of this invention as well as to cytolytic T cells which recognize the peptides in complex with an HLA molecule.
摘要翻译： 本发明涉及衍生自MAGE-C2的分离的肽，编码MAGE-C2的核酸分子和来自MAGE-C2的分离的肽，包含核酸分子的表达载体，用核酸分子转化或转染的宿主细胞 表达载体和包含肽，HLA分子，β2微球蛋白和第一和第二结合配偶体的四聚体。 本发明还涉及使用本发明的肽，核酸分子，表达载体，四聚体和复合物以及识别与HLA分子复合的肽的细胞溶解性T细胞的方法。
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