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公开(公告)号：US06372219B1
公开(公告)日：2002-04-16
申请号：US09180446
申请日：1999-10-19
IPC分类号： A61K3900
CPC分类号： C07K14/4354 , A61K38/00 , A61K39/00 , A61K39/0003 , Y02A50/423
摘要： A protein with anti-inflammatory, and immunomodulatory functions was identified and isolated from the excretory/secretions of a human parasite Schistosoma mansoni. This protein, designated herein as Sm 16.8, is released by schistosomes upon entry into human skin. Under in vitro conditions Sm 16.8 is shown to stimulate the production of anti-inflammatory cytokine Interleukin-1 receptor antagonist (IL-1ra) in human keratinocytes and transciptionally down regulate the production of proinflammatory cytokines IL-1 &agr; and IL-1 &bgr;.
摘要翻译： 从人类寄生虫曼氏血吸虫的排泄物/分泌物中鉴定并分离具有抗炎和免疫调节功能的蛋白质。 这种称为Sm 16.8的蛋白质在进入人体皮肤时被血吸虫释放。 在体外条件下，Sm 16.8可显示刺激人角质形成细胞中抗炎细胞因子白细胞介素-1受体拮抗剂（IL-1ra）的产生，并且转录调节产生促炎细胞因子IL-1α和IL-1β。
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公开(公告)号：US20050037970A1
公开(公告)日：2005-02-17
申请号：US10946272
申请日：2004-09-20
IPC分类号： A61K38/00 , A61K39/00 , C07K14/435 , A61K38/16 , C07K14/195
CPC分类号： C07K14/4354 , A61K38/00 , A61K39/00 , A61K39/0003 , Y02A50/423
摘要： A protein with anti-inflammatory, and immunomodulatory functions was identified and isolated from the excretory/secretions of a human parasite, Schistosoma mansoni. This protein, designated herein as Sm 16.8, is released by schistosomes upon entry into human skin. Under in vitro conditions Sm 16.8 is shown to stimulate the production of anti-inflammatory cytokine Interleukin-1 receptor antagonist (IL-1ra) in human keratinocytes and transcriptionally down regulate the production of pro-inflamnmatory cytokines IL-1 and IL-1.
摘要翻译： 从人类寄生虫血吸虫血清的排泄/分泌物中鉴定并分离具有抗炎和免疫调节功能的蛋白质。 这种称为Sm 16.8的蛋白质在进入人体皮肤时被血吸虫释放。 在体外条件下，Sm 16.8显示刺激人角质形成细胞中抗炎细胞因子白细胞介素-1受体拮抗剂（IL-1ra）的产生，并转录下调节促炎细胞因子IL-1和IL-1的产生。
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3.发明授权Anti-parasitic action of N,N-diethyl-m-toluamide (deet) and formulations that prolong its activity in the skin 有权N，N-二乙基 - 间甲苯酰胺（deet）和延长其在皮肤中的活性的制剂的抗寄生作用公开(公告)号：US06447801B1
公开(公告)日：2002-09-10
申请号：US09283883
申请日：1999-04-01
IPC分类号： A01N2528
CPC分类号： A61K9/0017 , A01N37/18 , A61K9/127 , A61K31/165 , A61K31/166 , Y02A50/423 , Y10S424/10 , Y10S514/875 , Y10S514/919 , A01N2300/00
摘要： Novel formulations of DEET are provided which comprise liposomes and other carriers. Methods and materials for preventing Schistomiasis and other parasitic and microbial diseases are also provided. Also provided are improved materials and methods for repelling biting insects.
摘要翻译： 提供了包含脂质体和其它载体的新型DEET制剂。 还提供了用于预防麻疹病和其他寄生虫和微生物疾病的方法和材料。 还提供了用于排斥叮咬昆虫的改进的材料和方法。
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