公开(公告)号：US20090186809A1

公开(公告)日：2009-07-23

申请号：US12295359

申请日：2007-03-13

申请人： Bernd Hentsch ,  Sylvia Schwarz

发明人： Bernd Hentsch ,  Sylvia Schwarz

IPC分类号： A61K38/12 ,  A61K31/19 ,  A61K31/165 ,  A61K38/00

CPC分类号： A61K31/19

摘要： The present invention provides a surprising therapeutic beneficial use for the topical application of valproic acid as a single agent therapy for patients suffering from mild to moderate acne vulgaris. Topically applied VPA has a clinical efficacy comparable to that of the marketed standard medication for this indication, isotretinoin. Furthermore, topically applied VPA is on average well to very well tolerated. The invention relates to the topical medical use of VPA for the treatment of acne vulgaris and comprises the topical application of VPA or of a pharmaceutically acceptable salt thereof.

摘要翻译： 本发明提供了一种令人惊奇的治疗有益用途，其用于局部应用丙戊酸作为患有轻度至中度寻常型痤疮的患者的单一药物治疗。 局部应用VPA具有与市售标准药物相当的临床效果，用于该指征异维A酸。 此外，局部应用的VPA平均得到很好的耐受性。 本发明涉及用于治疗寻常痤疮的VPA的局部医学用途，并且包括局部应用VPA或其药学上可接受的盐。

公开(公告)号：US20080181894A1

公开(公告)日：2008-07-31

申请号：US11912533

申请日：2006-04-21

申请人： Sigrun Mink ,  Joerg Mengwasser ,  Elke Martin ,  Birgit Simgen ,  Monika Raab ,  Sylvia Schwarz ,  Bernd Hentsch

发明人： Sigrun Mink ,  Joerg Mengwasser ,  Elke Martin ,  Birgit Simgen ,  Monika Raab ,  Sylvia Schwarz ,  Bernd Hentsch

IPC分类号： A61K31/70 ,  C12Q1/68 ,  G01N33/574 ,  C12Q1/02 ,  A61K39/395 ,  A61P43/00 ,  A61K38/00 ,  C12Q1/04 ,  C07H21/00

CPC分类号： C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/136 ,  C12Q2600/158

摘要： The present invention relates to methods using newly identified cancer related polynucleotides and the polypeptides encoded by these polynucleotides. The invention further relates to the use of such “cancer antigens” for diagnosing cancer and cancer metastases. The invention relates to the use of these cancer antigens employing expression vectors, host cells, antibodies directed to such cancer antigens, and recombinant methods and synthetic methods for producing the same. Also provided are diagnostic and prognostic methods for detecting, treating, or preventing cancer, for suppressing tumor progression and minimal residual tumor disease, and therapeutic methods for treating such disorders. The invention further relates to screening methods for identifying agonists and antagonists of the cancer antigens of the invention. The present invention further relates to inhibiting the production and function of the polynucleotides and polypeptides of the present invention.

摘要翻译： 本发明涉及使用新鉴定的癌症相关多核苷酸的方法和由这些多核苷酸编码的多肽。 本发明还涉及这种“癌症抗原”用于诊断癌症和癌症转移的用途。 本发明涉及使用表达载体，宿主细胞，针对这种癌抗原的抗体的这些癌抗原的用途，以及重组方法及其制备方法。 还提供了用于检测，治疗或预防癌症，抑制肿瘤进展和最小残留肿瘤疾病的诊断和预后方法，以及用于治疗这些疾病的治疗方法。 本发明还涉及用于鉴定本发明的癌抗原的激动剂和拮抗剂的筛选方法。 本发明还涉及抑制本发明的多核苷酸和多肽的产生和功能。