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1.Composition exhibiting a von willebrand factor (vWF) protease activity comprising a polypeptide chain with the amino acid sequence AAGGILHLELLV 有权
标题翻译: 表现出von Willebrand因子(vWF)蛋白酶活性的组合物,其包含具有氨基酸序列AAGGILHLELLV的多肽链公开(公告)号:US07910094B2
公开(公告)日:2011-03-22
申请号:US12370129
申请日:2009-02-12
申请人: Bernhard Laemmle , Helena Elisabeth Schaller-Gerritsen , Miha Furlan , Peter Turecek , Hans-Peter Schwarz , Friedrich Scheiflinger , Gerhard Antoine , Randolf Kerschbaumer , Luigina Tagliavacca , Klaus Zimmermann
发明人: Bernhard Laemmle , Helena Elisabeth Schaller-Gerritsen , Miha Furlan , Peter Turecek , Hans-Peter Schwarz , Friedrich Scheiflinger , Gerhard Antoine , Randolf Kerschbaumer , Luigina Tagliavacca , Klaus Zimmermann
CPC分类号: A61K38/4886 , A61K38/00 , C07K14/755 , C07K16/36 , C12N9/6416 , C12N9/6489 , C12Y304/24087
摘要: The invention relates to vWF cleaving entities having a molecular weight of 180 kD, 170 kD, 160 kD, 120 kD or 110 kD and an N-terminal amino acid sequence of AAGGILHLELLV, vWF cleaving complexes and methods for their production.
摘要翻译: 本发明涉及分子量为180kD,170kD,160kD,120kD或110kD的VWF切割实体以及AAGGILHLELLV的N-末端氨基酸序列,vWF切割复合物及其生产方法。
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公开(公告)号:US20090203110A1
公开(公告)日:2009-08-13
申请号:US12370129
申请日:2009-02-12
申请人: Bernhard Laemmle , Helena Elisabeth Schaller-Gerritsen , Miha Furlan , Peter Turecek , Hans-Peter Schwarz , Friedrich Scheiflinger , Gerhard Antoine , Randolf Kerschbaumer , Luigina Tagliavacca , Klaus Zimmermann
发明人: Bernhard Laemmle , Helena Elisabeth Schaller-Gerritsen , Miha Furlan , Peter Turecek , Hans-Peter Schwarz , Friedrich Scheiflinger , Gerhard Antoine , Randolf Kerschbaumer , Luigina Tagliavacca , Klaus Zimmermann
IPC分类号: C12N9/50
CPC分类号: A61K38/4886 , A61K38/00 , C07K14/755 , C07K16/36 , C12N9/6416 , C12N9/6489 , C12Y304/24087
摘要: The invention relates to vWF cleaving entities having a molecular weight of 180 kD, 170 kD, 160 kD, 120 kD or 110 kD and an N-terminal amino acid sequence of AAGGILHLELLV, vWF cleaving complexes and methods for their production.
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3.Composition exhibiting a von Willebrand factor (vWF) protease activity comprising a polypeptide chain with the amino acid sequence AAGGILHLELLV 有权
标题翻译: 表现出von Willebrand因子(vWF)蛋白酶活性的组合物,其包含具有氨基酸序列AAGGILHLELLV的多肽链公开(公告)号:US07501117B2
公开(公告)日:2009-03-10
申请号:US11166288
申请日:2005-06-23
申请人: Bernhard Laemmle , Helena Elisabeth Schaller-Gerritsen , Miha Furlan , Peter Turecek , Hans-Peter Schwarz , Friedrich Scheiflinger , Gerhard Antoine , Randolf Kerschbaumer , Luigina Tagliavacca , Klaus Zimmermann
发明人: Bernhard Laemmle , Helena Elisabeth Schaller-Gerritsen , Miha Furlan , Peter Turecek , Hans-Peter Schwarz , Friedrich Scheiflinger , Gerhard Antoine , Randolf Kerschbaumer , Luigina Tagliavacca , Klaus Zimmermann
CPC分类号: A61K38/4886 , A61K38/00 , C07K14/755 , C07K16/36 , C12N9/6416 , C12N9/6489 , C12Y304/24087
摘要: The invention relates to vWF cleaving entities having a molecular weight of 180 kD, 170 kD, 160 kD, 120 kD or 110 kD and an N-terminal amino acid sequence of AAGGILHLELLV, vWF cleaving complexes and methods for their production.
摘要翻译: 本发明涉及分子量为180kD,170kD,160kD,120kD或110kD的VWF切割实体以及AAGGILHLELLV的N-末端氨基酸序列,vWF切割复合物及其生产方法。
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公开(公告)号:US08703429B2
公开(公告)日:2014-04-22
申请号:US12171934
申请日:2008-07-11
申请人: Bernhard Laemmle , Helena Elisabeth Schaller-Gerritsen , Miha Furlan , Peter Turecek , Hans-Peter Schwarz , Friedrich Scheiflinger , Gerhard Antoine , Randolf Kerschbaumer , Luigina Tagliavacca , Klaus Zimmermann
发明人: Bernhard Laemmle , Helena Elisabeth Schaller-Gerritsen , Miha Furlan , Peter Turecek , Hans-Peter Schwarz , Friedrich Scheiflinger , Gerhard Antoine , Randolf Kerschbaumer , Luigina Tagliavacca , Klaus Zimmermann
CPC分类号: A61K38/4886 , A61K38/00 , C07K14/755 , C07K16/36 , C12N9/6416 , C12N9/6489 , C12Y304/24087
摘要: The invention relates to vWF cleaving entities having a molecular weight of 180 kD, 170 kD, 160 kD, 120 kD or 110 kD and an N-terminal amino acid sequence of AAGGILHLELLV, vWF cleaving complexes and methods for their production.
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5.Composition exhibiting a von Willebrand Factor (vWF) protease activity with the amino acid sequence AAGGILHLELLV 有权
标题翻译: 显示von Willebrand因子(vWF)蛋白酶活性的组合包含具有氨基酸序列AAGGILHLELLV的多肽链公开(公告)号:US08703426B2
公开(公告)日:2014-04-22
申请号:US12032553
申请日:2008-02-15
申请人: Bernhard Laemmle , Helena Elisabeth Schaller-Gerritsen , Miha Furlan , Peter Turecek , Hans-Peter Schwarz , Friedrich Scheiflinger , Gerhard Antoine , Randolf Kerschbaumer , Luigina Tagliavacca , Klaus Zimmermann
发明人: Bernhard Laemmle , Helena Elisabeth Schaller-Gerritsen , Miha Furlan , Peter Turecek , Hans-Peter Schwarz , Friedrich Scheiflinger , Gerhard Antoine , Randolf Kerschbaumer , Luigina Tagliavacca , Klaus Zimmermann
CPC分类号: A61K38/4886 , A61K38/00 , C07K14/755 , C07K16/36 , C12N9/6416 , C12N9/6489 , C12Y304/24087
摘要: The invention relates to vWF cleaving entities having a molecular weight of 180 kD, 170 kD, 160 kD, 120 kD or 110 kD and an N-terminal amino acid sequence of AAGGILHLELLV, vWF cleaving complexes and methods for their production.
摘要翻译: 本发明涉及分子量为180kD,170kD,160kD,120kD或110kD的VWF切割实体以及AAGGILHLELLV的N-末端氨基酸序列,vWF切割复合物及其生产方法。
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6.COMPOSITION EXHIBITING A VON WILLEBRAND FACTOR (vWF) PROTEASE ACTIVITY COMPRISING A POLYPEPTIDE CHAIN WITH THE AMINO ACID SEQUENCE AAGGILHLELLV 有权
标题翻译: 组合物展示包含氨基酸序列的多肽链的VON WILLEBRAND因子(vWF)蛋白酶活性AAGGILHLELLV公开(公告)号:US20090017467A1
公开(公告)日:2009-01-15
申请号:US12171934
申请日:2008-07-11
申请人: Bernhard Laemmle , Helena Elisabeth Schaller-Gerritsen , Miha Furlan , Peter Turecek , Hans-Peter Schwarz , Friedrich Scheiflinger , Gerhard Antoine , Randolf Kerschbaumer , Luigina Tagliavacca , Klaus Zimmermann
发明人: Bernhard Laemmle , Helena Elisabeth Schaller-Gerritsen , Miha Furlan , Peter Turecek , Hans-Peter Schwarz , Friedrich Scheiflinger , Gerhard Antoine , Randolf Kerschbaumer , Luigina Tagliavacca , Klaus Zimmermann
IPC分类号: G01N33/573
CPC分类号: A61K38/4886 , A61K38/00 , C07K14/755 , C07K16/36 , C12N9/6416 , C12N9/6489 , C12Y304/24087
摘要: The invention relates to vWF cleaving entities having a molecular weight of 180 kD, 170 kD, 160 kD, 120 kD or 110 kD and an N-terminal amino acid sequence of AAGGILHLELLV, vWF cleaving complexes and methods for their production.
摘要翻译: 本发明涉及分子量为180kD,170kD,160kD,120kD或110kD的VWF切割实体以及AAGGILHLELLV的N-末端氨基酸序列,vWF切割复合物及其生产方法。
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7.Composition exhibiting a von willebrand factor (vWF) protease activity comprising a polypeptide chain with the amino acid sequence AAGGILHLELLV 有权
标题翻译: 表现出von Willebrand因子(vWF)蛋白酶活性的组合物,其包含具有氨基酸序列AAGGILHLELLV的多肽链公开(公告)号:US06926894B2
公开(公告)日:2005-08-09
申请号:US09833328
申请日:2001-04-12
申请人: Bernhard Laemmle , Helena Elisabeth Gerritsen , Miha Furlan , Peter Turecek , Hans-Peter Schwarz , Friedrich Scheiflinger , Gerhard Antoine , Randolf Kerschbaumer , Luigina Tagliavacca , Klaus Zimmermann
发明人: Bernhard Laemmle , Helena Elisabeth Gerritsen , Miha Furlan , Peter Turecek , Hans-Peter Schwarz , Friedrich Scheiflinger , Gerhard Antoine , Randolf Kerschbaumer , Luigina Tagliavacca , Klaus Zimmermann
CPC分类号: A61K38/4886 , A61K38/00 , C07K14/755 , C07K16/36 , C12N9/6416 , C12N9/6489 , C12Y304/24087
摘要: The invention relates to vWF cleaving entities having a molecular weight of 180 kD, 170 kD, 160 kD, 120 kD or 110 kD and an N-terminal amino acid sequence of AAGGILHLELLV (SEQ ID NO: 1), vWF cleaving complexes and methods for their production.
摘要翻译: 本发明涉及分子量为180kD,170kD,160kD,120kD或110kD的VWF切割实体以及AAGGILHLELLV(SEQ ID NO:1)的N-末端氨基酸序列,vWF切割复合物和用于 他们的生产。
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8.Composition Exhibiting a von Willebrand Factor (vWF) Protease Activity Comprising a Polypeptide Chain with the Amino Acid Sequence AAGGILHLELLV 有权
标题翻译: 组成展示von Willebrand因子(vWF)包含氨基酸序列的多肽链的蛋白酶活性AAGGILHLELLV公开(公告)号:US20080176312A1
公开(公告)日:2008-07-24
申请号:US12032553
申请日:2008-02-15
申请人: Bernhard Laemmle , Helena Elisabeth Gerritsen , Miha Furlan , Peter Turecek , Hans-Peter Schwarz , Friedrich Scheiflinger , Gerhard Antoine , Randolf Kerschbaumer , Luigina Tagliavacca , Klaus Zimmermann
发明人: Bernhard Laemmle , Helena Elisabeth Gerritsen , Miha Furlan , Peter Turecek , Hans-Peter Schwarz , Friedrich Scheiflinger , Gerhard Antoine , Randolf Kerschbaumer , Luigina Tagliavacca , Klaus Zimmermann
IPC分类号: C12N9/50
CPC分类号: A61K38/4886 , A61K38/00 , C07K14/755 , C07K16/36 , C12N9/6416 , C12N9/6489 , C12Y304/24087
摘要: The invention relates to vWF cleaving entities having a molecular weight of 180 kD, 170 kD, 160 kD, 120 kD or 110 kD and an N-terminal amino acid sequence of AAGGILHLELLV, vWF cleaving complexes and methods for their production.
摘要翻译: 本发明涉及分子量为180kD,170kD,160kD,120kD或110kD的VWF切割实体以及AAGGILHLELLV的N-末端氨基酸序列,vWF切割复合物及其生产方法。
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9.Composition exhibiting a von Willebrand factor (vWF) protease activity comprising a polypeptide chain with the amino acid sequence AAGGILHLELLV 有权
标题翻译: 表现出von Willebrand因子(vWF)蛋白酶活性的组合物,其包含具有氨基酸序列AAGGILHLELLV的多肽链公开(公告)号:US20050266528A1
公开(公告)日:2005-12-01
申请号:US11166288
申请日:2005-06-23
申请人: Bernhard Laemmie , Helena Gerritsen , Miha Furlan , Peter Turecek , Hans-Peter Schwarz , Friedrich Schelflinger , Gerhard Antoine , Randolf Kerschbaumer , Luigina Tagliavacca , Klaus Zimmermann
发明人: Bernhard Laemmie , Helena Gerritsen , Miha Furlan , Peter Turecek , Hans-Peter Schwarz , Friedrich Schelflinger , Gerhard Antoine , Randolf Kerschbaumer , Luigina Tagliavacca , Klaus Zimmermann
CPC分类号: A61K38/4886 , A61K38/00 , C07K14/755 , C07K16/36 , C12N9/6416 , C12N9/6489 , C12Y304/24087
摘要: The invention relates to vWF cleaving entities having a molecular weight of 180 kD, 170 kD, 160 kD, 120 kD or 110 kD and an N-terminal amino acid sequence of AAGGILHLELLV, vWF cleaving complexes and methods for their production.
摘要翻译: 本发明涉及分子量为180kD,170kD,160kD,120kD或110kD的VWF切割实体以及AAGGILHLELLV的N-末端氨基酸序列,vWF切割复合物及其生产方法。
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10.
公开(公告)号:US07279161B2
公开(公告)日:2007-10-09
申请号:US11093103
申请日:2005-03-28
申请人: Friedrich Scheiflinger , Randolf Kerschbaumer , Falko-Guenter Falkner , Friedrich Dorner , Hans-Peter Schwarz
发明人: Friedrich Scheiflinger , Randolf Kerschbaumer , Falko-Guenter Falkner , Friedrich Dorner , Hans-Peter Schwarz
IPC分类号: A61K39/395
CPC分类号: C07K16/40 , A61K2039/505
摘要: An antibody or antibody derivative against factor IX/activated factor IX (FIXa) which increases the procoagulant activity of FIXa.
摘要翻译: 针对因子IX /活化因子IX(FIXa)的抗体或抗体衍生物,其增加FIXa的促凝血活性。
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