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    Targeted Delivery of Retinoid Compounds to the Sebaceous Glands
    6.
    发明申请
    Targeted Delivery of Retinoid Compounds to the Sebaceous Glands 审中-公开
    维甲酸化合物靶向递送到皮脂腺

    公开(公告)号：US20120328670A1

    公开(公告)日：2012-12-27

    申请号：US13486137

    申请日：2012-06-01

    申请人： John E. Donello ,  Rong Yang

    发明人： John E. Donello ,  Rong Yang

    IPC分类号： A61K9/14 ,  A61P17/10 ,  A61P17/00 ,  A61K31/4436

    CPC分类号： A61K9/0014 ,  A61K9/5031 ,  A61K31/4436

    摘要： Disclosed herein are topical dermal compositions comprising particles, wherein the particles comprisea) a biodegradable polymer, andb) a retinoid selected from the group consisting of: or a pharmaceutically acceptable salt thereof, wherein the particles have an average diameter between 0.1 μm and 10 μm, and wherein the variables are as defined in the specification. The compositions are useful for treating a condition associated with excess sebum production.

    摘要翻译： 本文公开了包含颗粒的局部皮肤组合物，其中所述颗粒包含a）生物可降解聚合物，和b）选自以下的类视色素：或其药学上可接受的盐，其中所述颗粒的平均直径为0.1μm至10μm μm，并且其中变量如说明书中所定义。 组合物可用于治疗与过量皮脂生成相关的病症。

    Accurate ECG I-point and J-point detection and measurement
    9.
    发明授权
    Accurate ECG I-point and J-point detection and measurement 有权

    公开(公告)号：US10092201B2

    公开(公告)日：2018-10-09

    申请号：US15961952

    申请日：2018-04-25

    申请人： Guangren Chen ,  Rong Yang ,  Zhongnong Jiang

    发明人： Guangren Chen ,  Rong Yang ,  Zhongnong Jiang

    IPC分类号： A61B5/04 ,  A61B5/0402 ,  A61B5/0245 ,  A61B5/00 ,  A61B5/044

    摘要： An ECG system measures and annotates the I-point of in an ECG waveform from harmonic waveforms. Electrical impulses are received from a beating heart. The electrical impulses are converted to an ECG waveform. The ECG waveform is converted to a frequency domain waveform, which, in turn, is separated into two or more different frequency domain waveforms, which, in turn, are converted into a plurality of time domain cardiac electrophysiological subwaveforms and discontinuity points between these subwaveforms. The plurality of subwaveforms and discontinuity points are compared to a database of subwaveforms and discontinuity points for normal and abnormal patients. A discontinuity point is identified as the I-point of the ECG waveform from the comparison. The ECG waveform is displayed along with a marker at a location of the discontinuity point.

    Automated ECG Analysis and Diagnosis System
    10.
    发明申请
    Automated ECG Analysis and Diagnosis System 审中-公开

    公开(公告)号：US20180184931A1

    公开(公告)日：2018-07-05

    申请号：US15904543

    申请日：2018-02-26

    申请人： Guangren Chen ,  Rong Yang ,  Zhongnong Jiang

    发明人： Guangren Chen ,  Rong Yang ,  Zhongnong Jiang

    IPC分类号： A61B5/04 ,  A61B5/0468 ,  A61B5/00 ,  A61B5/0464 ,  A61B5/046

    CPC分类号： A61B5/04012 ,  A61B5/0408 ,  A61B5/046 ,  A61B5/0464 ,  A61B5/0468 ,  A61B5/725 ,  A61B5/7257

    摘要： An ECG system identifies and annotates cardiac electrophysiological signals in an ECG waveform from harmonic waveforms. Electrical impulses are received from a beating heart. The electrical impulses are converted to an ECG waveform. The ECG waveform is converted to a frequency domain waveform, which, in turn, is separated into two or more different frequency domain waveforms, which, in turn, are converted into a plurality of time domain cardiac electrophysiological subwaveforms and discontinuity points between these subwaveforms. The plurality of subwaveforms and discontinuity points are compared to a database of subwaveforms and discontinuity points for normal and abnormal patients. At least one subwaveform or one or more discontinuity points are identified as a normal or abnormal electrophysiological signal of the ECG waveform from the comparison. The ECG waveform is displayed along with one or more markers at a location of the at least one subwaveform or one or more discontinuity points.