专利检索 ap:("Beth Israel Deaconess Medical Center, Inc." OR "President AND Fellows of Harvard College") AND inv:"David Mooney" 第 1 页

1.

发明公开
RECOMBINANT NUCLEIC ACID MOLECULES AND THEIR USE IN WOUND HEALING 审中-公开

公开(公告)号：US20240238473A1

公开(公告)日：2024-07-18

申请号：US18408498

申请日：2024-01-09

申请人： Beth Israel Deaconess Medical Center, Inc. , President and Fellows of Harvard College

发明人： Aristidis Veves , George Theocharidis , Zhuqing Li , Ioannis Vlachos , David Mooney , Sangmin Lee

IPC分类号： A61L15/32 , A61K38/00 , A61K47/69 , A61L15/28 , C07K14/47 , C07K14/55 , C12Q1/6811

CPC分类号： A61L15/32 , A61K47/6929 , A61L15/28 , C07K14/473 , C07K14/55 , C12Q1/6811 , A61K38/00

摘要： In certain aspects, the disclosure relates to a recombinant nucleic acid molecule (e.g. RNA molecule) encoding one or more polypeptides selected from the group consisting of chitinase-3-like protein 1 (CHI3L1), a fibroblast growth factor (FGF), interleukin-2 ORF7 (IL-2 ORF7), interleukin-2 (IL-2), an interleukin-17 (IL-17) protein, and an IL-17 receptor, wherein the recombinant RNA molecule comprises at least one chemical modification. Cells, pharmaceutical compositions and wound dressings comprising one or more of the recombinant nucleic acid molecules are also disclosed. Methods of promoting wound healing in a subject are further disclosed.