公开(公告)号：US20230339882A1

公开(公告)日：2023-10-26

申请号：US18016144

申请日：2021-07-22

Applicant: Betta Pharmaceuticals Co., Ltd.

Inventor： Hao WU ,  Wenmao WU ,  Ling LI ,  Zhan ZHANG ,  Feng WANG ,  Ding YUAN ,  Yunfei WU ,  Qiang CHEN ,  Han HAN ,  Jing GUO ,  Hong LAN ,  Lieming DING ,  Jiabing WANG

IPC: C07D401/04 ,  A61P35/00 ,  C07D401/14 ,  C07D413/14 ,  C07D405/14 ,  C07D491/107 ,  C07D471/10 ,  C07D513/10 ,  C07D498/10

CPC classification number: C07D401/04 ,  A61P35/00 ,  C07D401/14 ,  C07D405/14 ,  C07D413/14 ,  C07D471/10 ,  C07D491/107 ,  C07D498/10 ,  C07D513/10

Abstract: A compound (as represented by formula I) serving as an Src homology region 2-containing protein tyrosine phosphatase 2 (SHP2) inhibitor, as well as a pharmaceutical composition thereof, a preparation method therefor, and a use in treating an SHP2 mediation diseases. The compounds of formula I exerts an effect by means of participating in the regulation of multiple processes such as cell proliferation, apoptosis, migration, and angiogenesis.

公开(公告)号：US20240342169A1

公开(公告)日：2024-10-17

申请号：US18682227

申请日：2022-08-04

Applicant: BETTA PHARMACEUTICALS CO., LTD

Inventor： Lijia LIU ,  Jing GUO ,  Yu WANG ,  Xiangdong ZHAO ,  Jie CHEN ,  Yang WANG ,  Xiaobin YUAN ,  Dong JI ,  Licheng KONG ,  Lieming DING

IPC: A61K31/501 ,  A61P35/00

CPC classification number: A61K31/501 ,  A61P35/00

Abstract: Embodiments of the present application provide Ensartinib or a salt thereof and a use of a composition containing Ensartinib or the salt thereof in treatment of a disease carrying MET 14 exon skipping mutation.

公开(公告)号：US20230391779A1

公开(公告)日：2023-12-07

申请号：US18021784

申请日：2021-08-17

Applicant: Betta Pharmaceuticals Co., Ltd.

Inventor： Xiaofeng XU ,  Jinheng GAO ,  Hongfei RONG ,  Xizhen SONG ,  Jie CHEN ,  Xiangyong LIU ,  Hongling SHEN ,  Jing GUO ,  Dan YAN ,  Hong LAN ,  Lieming DING ,  Jiabing WANG

IPC: C07D487/04 ,  C07D403/04 ,  C07D471/04 ,  C07D403/06 ,  C07D231/56 ,  C07D401/14 ,  C07D401/04 ,  C07D405/04 ,  C07D413/04 ,  C07D413/14 ,  C07D405/14 ,  C07D493/04 ,  C07C237/20 ,  C07D205/04 ,  A61P35/00

CPC classification number: C07D487/04 ,  A61P35/00 ,  C07D471/04 ,  C07D403/06 ,  C07D231/56 ,  C07D401/14 ,  C07D401/04 ,  C07D405/04 ,  C07D413/04 ,  C07D413/14 ,  C07D405/14 ,  C07D493/04 ,  C07C237/20 ,  C07D205/04 ,  C07D403/04

Abstract: The present invention relates to compounds of Formula (I), pharmaceutical compositions comprising such compounds and use thereof. The compounds are useful in treating, preventing or ameliorating diseases or disorders such as cancer.