公开(公告)号：US20240342169A1

公开(公告)日：2024-10-17

申请号：US18682227

申请日：2022-08-04

Applicant: BETTA PHARMACEUTICALS CO., LTD

Inventor： Lijia LIU ,  Jing GUO ,  Yu WANG ,  Xiangdong ZHAO ,  Jie CHEN ,  Yang WANG ,  Xiaobin YUAN ,  Dong JI ,  Licheng KONG ,  Lieming DING

IPC: A61K31/501 ,  A61P35/00

CPC classification number: A61K31/501 ,  A61P35/00

Abstract: Embodiments of the present application provide Ensartinib or a salt thereof and a use of a composition containing Ensartinib or the salt thereof in treatment of a disease carrying MET 14 exon skipping mutation.

公开(公告)号：US20230391779A1

公开(公告)日：2023-12-07

申请号：US18021784

申请日：2021-08-17

Applicant: Betta Pharmaceuticals Co., Ltd.

Inventor： Xiaofeng XU ,  Jinheng GAO ,  Hongfei RONG ,  Xizhen SONG ,  Jie CHEN ,  Xiangyong LIU ,  Hongling SHEN ,  Jing GUO ,  Dan YAN ,  Hong LAN ,  Lieming DING ,  Jiabing WANG

IPC: C07D487/04 ,  C07D403/04 ,  C07D471/04 ,  C07D403/06 ,  C07D231/56 ,  C07D401/14 ,  C07D401/04 ,  C07D405/04 ,  C07D413/04 ,  C07D413/14 ,  C07D405/14 ,  C07D493/04 ,  C07C237/20 ,  C07D205/04 ,  A61P35/00

CPC classification number: C07D487/04 ,  A61P35/00 ,  C07D471/04 ,  C07D403/06 ,  C07D231/56 ,  C07D401/14 ,  C07D401/04 ,  C07D405/04 ,  C07D413/04 ,  C07D413/14 ,  C07D405/14 ,  C07D493/04 ,  C07C237/20 ,  C07D205/04 ,  C07D403/04

Abstract: The present invention relates to compounds of Formula (I), pharmaceutical compositions comprising such compounds and use thereof. The compounds are useful in treating, preventing or ameliorating diseases or disorders such as cancer.

公开(公告)号：US20230053342A1

公开(公告)日：2023-02-23

申请号：US17773771

申请日：2020-11-04

Applicant: BETTA PHARMACEUTICALS CO., LTD

Inventor： Houxian ZU ,  Xizhen SONG ,  Kai CHEN ,  Xiangyong LIU ,  Jie CHEN ,  Yajing BIAN ,  Lieming DING ,  Jiabing WANG

IPC: C07D498/04 ,  C07D513/04 ,  A61P35/00

Abstract: An imidazolidinone compound represented by formula (I), or a stereoisomer thereof, a geometric isomer thereof, or a tautomer thereof, or a pharmaceutically acceptable salt thereof, a pharmaceutical composition containing the compound, a synthesis method therefor and use thereof.

公开(公告)号：US20210395256A1

公开(公告)日：2021-12-23

申请号：US17311105

申请日：2019-12-06

Applicant: Betta Pharmaceuticals Co., Ltd.

Inventor： Bang FU ,  Yinlong LI ,  Wei REN ,  Jie CHEN ,  Xiangyong LIU ,  Jiabing WANG ,  Lieming DING

IPC: C07D487/04 ,  C07D519/00

Abstract: The present invention relates to compounds of Formula I, methods of using the compounds as Trk inhibitors, and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders such as cancer or infections.

公开(公告)号：US20210269440A1

公开(公告)日：2021-09-02

申请号：US17260547

申请日：2019-07-19

Applicant: BETTA PHARMACEUTICALS CO., LTD

Inventor： Yao ZHANG ,  Yiqian WANG ,  Bang FU ,  Jie CHEN ,  Jiabing WANG ,  Lieming DING

IPC: C07D471/04

Abstract: The present invention relates to compounds of Formula I, methods of using the compounds as immunomodulators, and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders such as cancer or infections.