公开(公告)号：US20030191074A1

公开(公告)日：2003-10-09

申请号：US10057928

申请日：2002-01-29

Applicant: Bio-Rad Laboratories Inc.

Inventor： David Segev

IPC: A61K048/00 ,  C07H021/04 ,  A61K031/675 ,  A61K031/52 ,  A61K031/506

CPC classification number: C12Q1/6839 ,  C07B2200/11 ,  C12Q1/6832 ,  C12Q2525/117 ,  C12Q2525/113

Abstract: A compound which comprises a backbone having a plurality of chiral carbon atoms, the backbone bearing a plurality of ligands each being individually bound to a chiral carbon atom of the plurality of chiral carbon atoms, the ligands including one or more pair(s) of adjacent ligands each containing a moiety selected from the group consisting of a naturally occurring nucleobase and a nucleobase binding group, wherein moieties of the one or more pair(s) are directly linked to one another via a linker chain; building blocks for synthesizing the compound; and rises of the compound, particularly in antisense therapy.

Abstract translation: 包含具有多个手性碳原子的骨架的化合物，所述骨架具有多个配体，每个配体各自与多个手性碳原子的手性碳原子结合，所述配体包括一个或多个相邻的一对 各自含有选自天然存在的核碱基和核碱基结合基团的部分的配体，其中所述一个或多个对的部分通过连接体链彼此直接连接; 用于合成化合物的结构单元; 化合物的升高，特别是在反义治疗中。