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1.发明申请METHOD FOR SCREENING ANTI-LIGAND LIBRARIES FOR IDENTIFYING ANTI-LIGANDS SPECIFIC FOR DIFFERENTIALLY AND INFREQUENTLY EXPRESSED LIGANDS 审中-公开用于筛选用于识别特定用于差异和非正式表达的配偶的反配偶的反配偶图书馆的方法公开(公告)号：US20160312383A1
公开(公告)日：2016-10-27
申请号：US15055814
申请日：2016-02-29
发明人： Björn Frendéus
IPC分类号： C40B30/04 , G01N33/68 , G01N33/554 , C12N15/10
CPC分类号： C40B30/04 , C12N15/1037 , G01N33/554 , G01N33/6845
摘要： The present invention relates to screening methods and, in particular, to methods of screening anti-ligand libraries for identifying anti-ligands specific for differentially and/or infrequently expressed ligands. The method comprises the steps of providing a library of anti-ligands; providing a first subtractor ligand; providing a second target ligand; determining the amount of the first and second target ligands using one or more equations derived from the universal law of mass action; providing the determined amount of a first subtractor ligand; providing the determined amount of a second target ligand: providing separation means capable of use to isolate anti-ligand bound to the second target ligand from anti-ligand bound to the first subtractor ligand; exposing the library of to the first and second target ligands to permit binding of anti-ligands to ligands; and using the separation means to isolate the anti-ligand bound to second target ligand.
摘要翻译： 本发明涉及筛选方法，特别是涉及筛选抗配体文库以鉴定差异和/或不经表达的配体特异性的抗配体的方法。 该方法包括提供反配体文库的步骤; 提供第一减法器配体; 提供第二目标配体; 使用从普遍的质量作用定律得到的一个或多个方程确定第一和第二靶配体的量; 提供确定量的第一减法器配体; 提供确定量的第二靶配体：提供能够用于分离与第二靶配体结合的抗配体与与第一减阻配体结合的抗配体分离的分离装置; 将文库暴露于第一和第二靶配体以允许抗配体与配体的结合; 并使用分离装置分离与第二靶配体结合的反配体。
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公开(公告)号：US11447549B2
公开(公告)日：2022-09-20
申请号：US16633740
申请日：2018-07-26
发明人： Björn Frendéus , Linda Mårtensson , Monika Semmrich , Ingrid Teige , Stephen Beers , Aymen Al-Shamkhani , Juliet Gray , Martin Glennie
IPC分类号： A61K39/395 , C07K16/28 , A61K39/00
摘要： Described is the sequential administration of first a Treg depleting antibody molecule selected from antibody molecules, such as an antibody molecule binding specifically to target belonging to the tumour necrosis factor receptor superfamily (TNFRSF), such as a Treg depleting anti-4-1 BB antibody or a Treg depleting OX-40 antibody, and then an immunostimulatory antibody molecule, such as an immunostimulatory anti-4-1 BB anti-body or an immunostimulatory OX-40 antibody, for use in the treatment of cancer. Described are also novel anti-4-1 BB antibodies and novel OX-40 antibodies that may be used in such sequential administration.
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3.发明申请公开(公告)号：US20180221482A1
公开(公告)日：2018-08-09
申请号：US15846419
申请日：2017-12-19
发明人： Björn Frendéus , Markus Hansson
IPC分类号： A61K39/395 , A61K31/573 , A61K38/05 , A61K45/06 , C07K16/28 , A61K31/454 , A61K39/00
CPC分类号： A61K39/39558 , A61K31/454 , A61K31/573 , A61K38/05 , A61K45/06 , A61K2039/505 , A61K2039/545 , C07K16/2821 , C07K2317/21 , C07K2317/73 , C07K2317/732 , A61K2300/00
摘要： There is provided antibodies or antigen-binding fragments thereof with binding specificity for ICAM-1, together with further anti-cancer agents, and compositions thereof, for use in the treatment of cancer.
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公开(公告)号：US09803013B2
公开(公告)日：2017-10-31
申请号：US14250898
申请日：2014-04-11
CPC分类号： C07K16/2803 , A61K2039/505 , C07K16/2821 , C07K16/2833 , C07K16/4283 , C07K2317/21 , C07K2317/622 , C07K2317/73 , C07K2317/732 , C07K2317/75 , C07K2317/94
摘要： The invention provides binding molecules, including antibody molecules which selectively bind to a cell surface antigen of a target cell, and wherein the binding molecules, on binding the cell surface antigen, induce cell death of the target cell. There is also provided methods of and pharmaceutical compositions for cell death induction and uses thereof.
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5.发明申请METHOD FOR SCREENING ANTI-LIGAND LIBRARIES FOR IDENTIFYING ANTI-LIGANDS SPECIFIC FOR DIFFERENTIALLY AND INFREQUENTLY EXPRESSED LIGANDS 审中-公开用于筛选用于识别特定用于差异和非正式表达的配偶的反配偶的反配偶图书馆的方法公开(公告)号：US20140200152A1
公开(公告)日：2014-07-17
申请号：US14054392
申请日：2013-10-15
发明人： Björn Frendéus
IPC分类号： G01N33/554
CPC分类号： C40B30/04 , C12N15/1037 , G01N33/554 , G01N33/6845
摘要： The present invention relates to screening methods and, in particular, to methods of screening anti-ligand libraries for identifying anti-ligands specific for differentially and/or infrequently expressed ligands. The method comprises the steps of providing a library of anti-ligands; providing a first subtractor ligand; providing a second target ligand; determining the amount of the first and second target ligands using one or more equations derived from the universal law of mass action; providing the determined amount of a first subtractor ligand; providing the determined amount of a second target ligand; providing separation means capable of use to isolate anti-ligand bound to the second target ligand from anti-ligand bound to the first subtractor ligand; exposing the library of to the first and second target ligands to permit binding of anti-ligands to ligands; and using the separation means to isolate the anti-ligand bound to second target ligand.
摘要翻译： 本发明涉及筛选方法，特别是涉及筛选抗配体文库以鉴定差异和/或不经表达的配体特异性的抗配体的方法。 该方法包括提供反配体文库的步骤; 提供第一减法器配体; 提供第二目标配体; 使用从普遍的质量作用定律得到的一个或多个方程确定第一和第二靶配体的量; 提供确定量的第一减法器配体; 提供确定量的第二目标配体; 提供能够用于将与第二靶配体结合的抗配体与与第一减阻配体结合的抗配体分离的分离装置; 将文库暴露于第一和第二靶配体以允许抗配体与配体的结合; 并使用分离装置分离与第二靶配体结合的反配体。
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公开(公告)号：US10351970B2
公开(公告)日：2019-07-16
申请号：US15055814
申请日：2016-02-29
发明人： Björn Frendéus
IPC分类号： G01N33/68 , G01N33/554 , C12N15/10 , C40B30/04
摘要： The present invention relates to screening methods and, in particular, to methods of screening anti-ligand libraries for identifying anti-ligands specific for differentially and/or infrequently expressed ligands. The method comprises the steps of providing a library of anti-ligands: providing a first subtractor ligand; providing a second target ligand; determining the amount of the first and second target ligands using one or more equations derived from the universal law of mass action; providing the determined amount of a first subtractor ligand; providing the determined amount of a second target ligand; providing separation means capable of use to isolate anti-ligand bound to the second target ligand from anti-ligand bound to the first subtractor ligand; exposing the library of to the first and second target ligands to permit binding of anti-ligands to ligands; and using the separation means to isolate the anti-ligand bound to second target ligand.
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公开(公告)号：US20170107293A1
公开(公告)日：2017-04-20
申请号：US15311016
申请日：2015-05-15
发明人： Björn Frendéus , Ingrid Teige , Linda Mårtensson , Mark Cragg , Ali Roghanian
CPC分类号： C07K16/2887 , A61K9/0034 , A61K9/0048 , A61K9/0095 , A61K9/02 , A61K9/2018 , A61K9/2027 , A61K9/2054 , A61K9/2059 , A61K9/4858 , A61K9/4866 , A61K47/02 , A61K47/10 , A61K47/12 , A61K47/26 , A61K47/38 , A61K2039/507 , A61K2039/55 , C07K16/283 , C07K16/2893 , C07K16/30 , C07K2317/21 , C07K2317/33 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/75 , C07K2317/76 , C07K2317/77 , C07K2317/92 , C07K2317/94
摘要： Description of a composition comprising an antibody molecule and an agent for use in the treatment of refractory cancer and/or relapsed cancer, and of a method of treating refractory cancer and/or relapsed cancer comprising administering an antibody molecule and an agent. There are also described kits comprising the antibody molecule and agents.
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公开(公告)号：US20160280788A1
公开(公告)日：2016-09-29
申请号：US15007373
申请日：2016-01-27
发明人： Markus Hansson , Björn Frendéus
CPC分类号： C07K16/2821 , A61K9/0019 , A61K9/20 , A61K2039/505 , C07K16/28 , C07K2317/21 , C07K2317/24 , C07K2317/622 , C07K2317/73 , C07K2317/732 , C07K2317/734
摘要： There is provided antibodies or antigen-binding fragments thereof with binding specificity for ICAM-1, for use in the treatment of cancer in patients who have previously been treated for cancer and either not responded to said treatment or have previously responded to said treatment and subsequently relapsed.
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公开(公告)号：US20140314793A1
公开(公告)日：2014-10-23
申请号：US14250898
申请日：2014-04-11
IPC分类号： C07K16/30
CPC分类号： C07K16/2803 , A61K2039/505 , C07K16/2821 , C07K16/2833 , C07K16/4283 , C07K2317/21 , C07K2317/622 , C07K2317/73 , C07K2317/732 , C07K2317/75 , C07K2317/94
摘要： The invention provides binding molecules, including antibody molecules which selectively bind to a cell surface antigen of a target cell, and wherein the binding molecules, on binding the cell surface antigen, induce cell death of the target cell. There is also provided methods of and pharmaceutical compositions for cell death induction and uses thereof.
摘要翻译： 本发明提供了结合分子，包括选择性结合靶细胞的细胞表面抗原的抗体分子，并且其中结合分子在细胞表面抗原结合时诱导靶细胞的细胞死亡。 还提供了用于细胞死亡诱导的方法和药物组合物及其用途。
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