公开(公告)号：US20240339174A1

公开(公告)日：2024-10-10

申请号：US18289425

申请日：2022-05-04

申请人： BioNTech SE ,  InstaDeep Ltd.

发明人： Alexander Muik ,  Asaf Poran ,  Yunpeng Liu ,  Ugur Sahin ,  Karim Beguir ,  Marcin Skwark ,  Thomas Pierrot ,  Yunguan Fu

IPC分类号： G16B20/20 ,  C07K14/005 ,  G16B15/30 ,  G16B40/20

CPC分类号： G16B20/20 ,  C07K14/005 ,  G16B15/30 ,  G16B40/20 ,  C12N2770/20022

摘要： The present disclosure provides technologies for identifying, characterizing, and/or monitoring sequences of a variant of a reference infectious agent (e.g., but not limited to viral variants, for example in some embodiments SARS-CoV-2 variants) for transmissibility factors and/or immune escape potential, and/or for detecting and/or monitoring variants in environmental or biological samples, and/or for designing, preparing, and/or administering vaccines for such variants.

公开(公告)号：US20240355417A1

公开(公告)日：2024-10-24

申请号：US18618412

申请日：2024-03-27

申请人： BioNTech SE ,  InstaDeep Ltd

发明人： Alexander Muik ,  Ugur Sahin ,  Asaf Poran ,  Alexandra Walls ,  Yunguan Fu ,  Rafal Okuniewski ,  Nicolas Winfried Pfeuffer

IPC分类号： G16B20/50 ,  G16B40/20 ,  G16B45/00 ,  G16B50/30 ,  G16H50/80

CPC分类号： G16B20/50 ,  G16B40/20 ,  G16B45/00 ,  G16B50/30 ,  G16H50/80

摘要： The present disclosure, among other things, provides technologies for identifying, characterizing, and/or monitoring variant sequences of a particular reference infections agent. Among other things, systems, methods, and architectures described herein provide visualization and decision support tools that can, e.g., facilitate decision making processes by local authorities and improve pandemic response in terms of, e.g., resource allocation, policy making, and speed tailored vaccine development. The present disclosure also provides tools for analyzing circulating variants to predict mutations likely to increase immune evasion of infectious agents.

公开(公告)号：US20240321387A1

公开(公告)日：2024-09-26

申请号：US18289424

申请日：2022-05-04

申请人： BioNTech SE ,  InstaDeep Ltd

发明人： Alexander Muik ,  Asaf Poran ,  Yunpeng Liu ,  Ugur Sahin ,  Karim Beguir ,  Marcin Skwark ,  Thomas Pierrot ,  Yunguan Fu

IPC分类号： G16B15/30 ,  G06N3/045 ,  G06N3/08 ,  G06N5/01 ,  G06N20/00 ,  G16B40/20

CPC分类号： G16B15/30 ,  G06N3/045 ,  G06N3/08 ,  G06N5/01 ,  G06N20/00 ,  G16B40/20

摘要： A method is provided for identifying a number of variants of concern of a reference disease associated immunogen. The method uses a language model to perform inference on data representing each of a plurality of variants and data representing the reference immunogen. For each of the plurality of variants and the reference immunogen, a characteristic vector is derived from an output feature map of a hidden layer of the language model. For each of the plurality of variants, a measure of distance is generated for the variant that includes calculating a measure of distance between the characteristic vector of the variant and the characteristic vector of the reference immunogen. A semantic change score is calculated for each variant based on the generated measure of distance for that variant. A variant of the reference immunogen is selected based, at least in part, on the generated the semantic change scores.

公开(公告)号：US12019968B2

公开(公告)日：2024-06-25

申请号：US17538987

申请日：2021-11-30

申请人： InstaDeep Ltd

发明人： Yunguan Fu ,  Nabil Chouba ,  Alexandre Laterre

IPC分类号： G06F30/3953 ,  G06F30/3308 ,  G06F30/394 ,  G06F30/398 ,  G06N3/04 ,  G06N3/047 ,  G06N3/08 ,  G06N20/00 ,  G06F111/08

CPC分类号： G06F30/3953 ,  G06F30/3308 ,  G06F30/394 ,  G06F30/398 ,  G06N3/04 ,  G06N3/047 ,  G06N3/08 ,  G06N20/00 ,  G06F2111/08

摘要： A computer-implemented method, a system, and non-transitory computer-readable storage medium for designing electrical circuits are provided. In the method input data is received and processed to generate a representation of the electrical circuit. A first process is repeatedly performed to identify a plurality of candidate routes for connecting a first and second circuit element based on the representation. A candidate route is selected from the plurality of candidate routes based on a look ahead search. The first process includes selecting a first point in the representation, executing a second process to identify a set of candidate points, and selecting a second point from the set of candidate points. The second process comprises evaluating at least one candidate path extending in a linear direction from the first point to identify the set of candidate points based on at least a constraint and a topology of the electrical circuit.