公开(公告)号：US20030083267A1

公开(公告)日：2003-05-01

申请号：US09935461

申请日：2001-08-22

申请人： Biogen, Inc., a Massachusetts corporation

发明人： Steven P. Adams ,  Ko-Chung Lin ,  Wen-Cherng Lee ,  Alfredo C. Castro ,  Craig N. Zimmerman ,  Charles E. Hammond ,  Yu-Sheng Liao

IPC分类号： A61K038/05 ,  A61K031/663 ,  C07F009/09 ,  C07C35/18

CPC分类号： C07D213/75 ,  A61K38/00 ,  C07C237/22 ,  C07C255/19 ,  C07C271/22 ,  C07C275/28 ,  C07C275/42 ,  C07C275/54 ,  C07C311/06 ,  C07C311/21 ,  C07C317/50 ,  C07C323/60 ,  C07C2601/02 ,  C07C2601/14 ,  C07D209/42 ,  C07D213/55 ,  C07D215/48 ,  C07D277/48 ,  C07D317/60 ,  C07D405/12 ,  C07K7/06

摘要： The present invention relates to novel compounds that are useful for inhibition and prevention of cell adhesion and cell adhesion-mediated pathologies. This invention also relates to pharmaceutical formulations comprising these compounds and methods of using them for inhibition and prevention of cell adhesion and cell adhesion-mediated pathologies. The compounds and pharmaceutical compositions of this invention can be used as therapeutic or prophylactic agents. They are particularly well-suited for treatment of many inflammatory and autoimmune diseases.