公开(公告)号：US20150110792A1

公开(公告)日：2015-04-23

申请号：US14359784

申请日：2012-11-16

Applicant: Biogen Idec MA Inc. ,  University of Iowa Research Foundation

Inventor： Veronique Bailly ,  Ellen Garber ,  Paul D. Rennert ,  Nicholas Joseph Lennemann ,  Wendy Jean Maury ,  Sven Henrik Moller-Tank

IPC: C07K16/28

CPC classification number: C07K16/28 ,  A61K2039/505 ,  C07K16/2803 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92

Abstract: Antibodies and antibody fragments that bind to human TIM-1 on the BED face of the protein are disclosed. Also disclosed are methods of using the antibodies and antibody fragments to inhibit or reduce TIM-1 binding to phosphatidylserine, inhibit or reduce TIM-1 binding to dendritic cells, and treat or prevent immunological disorders such as inflammatory and autoimmune conditions.

Abstract translation: 公开了在蛋白质的BED面上结合人TIM-1的抗体和抗体片段。 还公开了使用抗体和抗体片段抑制或降低TIM-1与磷脂酰丝氨酸结合，抑制或降低TIM-1与树突状细胞的结合以及治疗或预防免疫学疾病如炎性和自身免疫病症的方法。

公开(公告)号：US09096665B2

公开(公告)日：2015-08-04

申请号：US13863574

申请日：2013-04-16

Applicant: Biogen IDEC MA, Inc.

Inventor： Antonin R. De Fougerolles ,  Victor E. Kotelianski ,  Carl Reid ,  Ellen Garber

IPC: A61K39/395 ,  C07K16/24 ,  A61K39/00

CPC classification number: C07K16/24 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92

Abstract: The invention provides antibodies that bind to a plurality of β-chemokines, particularly monocyte chemotactic proteins MCP-1, MCP-2 and MCP-3. The invention also provides cells producing the antibodies, and methods of making and using the same.

Abstract translation: 本发明提供结合多种化学试剂，特别是单核细胞趋化蛋白MCP-1，MCP-2和MCP-3的抗体。 本发明还提供产生抗体的细胞，以及制备和使用该抗体的方法。