公开(公告)号：US08969042B2

公开(公告)日：2015-03-03

申请号：US14226481

申请日：2014-03-26

Applicant: Biogen Idec MA Inc.

Inventor： Anthony Rossomando ,  R. Blake Pepinsky ,  BangJian Gong

IPC: C12P21/06 ,  C07K14/495

CPC classification number: C07K14/495 ,  A61K38/00 ,  C07K14/47 ,  Y02A50/473

Abstract: Compositions and methods for folding proteins belonging to the transforming growth factor beta superfamily are disclosed. The compositions and methods allow for the folding of such proteins when produced in an expression system that does not yield a properly folded, biologically active product.

Abstract translation: 公开了折叠属于转化生长因子β超家族的蛋白质的组合物和方法。 当在不产生适当折叠的生物活性产品的表达系统中产生时，组合物和方法允许折叠这些蛋白质。

公开(公告)号：US20140322752A1

公开(公告)日：2014-10-30

申请号：US14226481

申请日：2014-03-26

Applicant: Biogen Idec MA Inc.

Inventor： Anthony Rossomando ,  R. Blake Pepinsky ,  BangJian Gong

IPC: C07K14/495

CPC classification number: C07K14/495 ,  A61K38/00 ,  C07K14/47 ,  Y02A50/473

Abstract: Compositions and methods for folding proteins belonging to the transforming growth factor beta superfamily are disclosed. The compositions and methods allow for the folding of such proteins when produced in an expression system that does not yield a properly folded, biologically active product.

Abstract translation: 公开了折叠属于转化生长因子β超家族的蛋白质的组合物和方法。 当在不产生适当折叠的生物活性产品的表达系统中产生时，组合物和方法允许折叠这些蛋白质。