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Patent Agency Ranking
公开(公告)号：US20130237477A1
公开(公告)日：2013-09-12
申请号：US13679529
申请日：2012-11-16
Inventor： Anthony Rossomando , Jean-Sebastien Silvestre , Radia Tamarat
CPC classification number: A61K38/185 , A61K45/06 , C07K14/475
Abstract: Disclosed are methods of increasing vascularization in a tissue by administering a neublastin polypeptide to a mammal exhibiting impaired or inadequate blood flow in the tissue. The methods can be used to in the treatment or prevention of a disorder characterized by impaired or inadequate blood flow or to increase vascularization in an organ that has been transplanted into a subject.
Abstract translation: 公开了通过向显示组织中的血流受损或不足的哺乳动物施用新伯斯加蛋白多肽来增加组织中的血管形成的方法。 该方法可以用于治疗或预防以血液流通受损或不充分为特征的疾病，或增加移植到受试者中的器官中的血管形成。
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公开(公告)号：US20150344550A1
公开(公告)日：2015-12-03
申请号：US14589372
申请日：2015-01-05
Applicant: Biogen Idec MA Inc.
Inventor： Anthony Rossomando , Ping Jin
CPC classification number: C07K16/18 , C07K16/22 , C07K2317/21 , C07K2317/24 , C07K2317/54 , C07K2317/55 , C07K2317/622 , C07K2317/76 , G01N33/6827
Abstract: Antibodies and antigen binding fragments that bind to neublastin polypeptides are disclosed. Also disclosed are methods of using the antibodies and antigen binding fragments in assays for detecting the presence or amount of endogenous and/or exogenous neublastin in a sample and in methods of antagonizing neublastin bioactivity.
Abstract translation: 公开了结合新斯普霉素多肽的抗体和抗原结合片段。 还公开了在测定中使用抗体和抗原结合片段以检测样品中内源和/或外源性新生素的存在或量以及拮抗新兴霉素生物活性的方法中的方法。
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公开(公告)号：US08969042B2
公开(公告)日：2015-03-03
申请号：US14226481
申请日：2014-03-26
Applicant: Biogen Idec MA Inc.
Inventor： Anthony Rossomando , R. Blake Pepinsky , BangJian Gong
IPC: C12P21/06 , C07K14/495
CPC classification number: C07K14/495 , A61K38/00 , C07K14/47 , Y02A50/473
Abstract: Compositions and methods for folding proteins belonging to the transforming growth factor beta superfamily are disclosed. The compositions and methods allow for the folding of such proteins when produced in an expression system that does not yield a properly folded, biologically active product.
Abstract translation: 公开了折叠属于转化生长因子β超家族的蛋白质的组合物和方法。 当在不产生适当折叠的生物活性产品的表达系统中产生时，组合物和方法允许折叠这些蛋白质。
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公开(公告)号：US20140322752A1
公开(公告)日：2014-10-30
申请号：US14226481
申请日：2014-03-26
Applicant: Biogen Idec MA Inc.
Inventor： Anthony Rossomando , R. Blake Pepinsky , BangJian Gong
IPC: C07K14/495
CPC classification number: C07K14/495 , A61K38/00 , C07K14/47 , Y02A50/473
Abstract: Compositions and methods for folding proteins belonging to the transforming growth factor beta superfamily are disclosed. The compositions and methods allow for the folding of such proteins when produced in an expression system that does not yield a properly folded, biologically active product.
Abstract translation: 公开了折叠属于转化生长因子β超家族的蛋白质的组合物和方法。 当在不产生适当折叠的生物活性产品的表达系统中产生时，组合物和方法允许折叠这些蛋白质。
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公开(公告)号：US09138461B2
公开(公告)日：2015-09-22
申请号：US13679529
申请日：2012-11-16
Inventor： Anthony Rossomando , Jean-Sebastien Silvestre , Radia Tamarat
IPC: A61K38/18 , A61P9/10 , A61P41/00 , A61K45/06 , C07K14/475
CPC classification number: A61K38/185 , A61K45/06 , C07K14/475
Abstract: Disclosed are methods of increasing vascularization in a tissue by administering a neublastin polypeptide to a mammal exhibiting impaired or inadequate blood flow in the tissue. The methods can be used to in the treatment or prevention of a disorder characterized by impaired or inadequate blood flow or to increase vascularization in an organ that has been transplanted into a subject.
Abstract translation: 公开了通过向显示组织中的血流受损或不足的哺乳动物施用新伯斯加蛋白多肽来增加组织中的血管形成的方法。 该方法可以用于治疗或预防以血液流通受损或不充分为特征的疾病，或增加移植到受试者中的器官中的血管形成。
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