公开(公告)号：US20220153874A1

公开(公告)日：2022-05-19

申请号：US17050353

申请日：2019-04-25

Applicant: Biogen MA Inc. ,  Neurimmune AG

Inventor： Jan Grimm ,  Fabio Montrasio ,  Isin Dalkilic-Liddle ,  Mia Marie Rushe ,  Joseph Walter Arndt

IPC: C07K16/44 ,  A61K49/00 ,  A61K47/68 ,  A61K51/10

Abstract: Provided are novel dipeptide repeat (DPR) specific antibodies (e.g., human-derived antibodies) as well as synthetic variants and biotechnological derivatives thereof, capable of binding C9orf72 poly-glycine-alanine DPRs, as well as methods and uses related thereto. The antibody of the present invention can be used in pharmaceutical and diagnostic compositions for DPR protein-targeted immunotherapy and diagnostics.

公开(公告)号：US11827702B2

公开(公告)日：2023-11-28

申请号：US17900161

申请日：2022-08-31

Applicant: Biogen MA Inc.

Inventor： Isin Dalkilic-Liddle ,  Benjamin A. Smith ,  Karl J. M. Hanf ,  Fang Qian ,  R. Blake Pepinsky ,  Thomas O. Cameron

IPC: C07K16/28 ,  C12N15/113

CPC classification number: C07K16/28 ,  C12N15/113 ,  C07K2317/565

Abstract: The present disclosure provides anti-transferrin receptor antibodies, compositions comprising the same and methods of their use. This disclosure also provides polynucleotides and vectors encoding the anti-transferrin receptor antibodies and cells comprising the same, methods of making the antibodies, and molecules comprising the antibodies.

公开(公告)号：US12162952B2

公开(公告)日：2024-12-10

申请号：US17050353

申请日：2019-04-25

Applicant: Biogen MA Inc. ,  Neurimmune AG

Inventor： Jan Grimm ,  Fabio Montrasio ,  Isin Dalkilic-Liddle ,  Mia Marie Rushe ,  Joseph Walter Arndt

IPC: C07K16/00 ,  A61K47/68 ,  A61K49/00 ,  A61K51/10 ,  C07K16/44 ,  G01N33/53

Abstract: Provided are novel dipeptide repeat (DPR) specific antibodies (e.g., human-derived antibodies) as well as synthetic variants and biotechnological derivatives thereof, capable of binding C9orf72 poly-glycine-alanine DPRs, as well as methods and uses related thereto. The antibody of the present invention can be used in pharmaceutical and diagnostic compositions for DPR protein-targeted immunotherapy and diagnostics.

公开(公告)号：US20240158494A1

公开(公告)日：2024-05-16

申请号：US18490319

申请日：2023-10-19

Applicant: Biogen MA Inc.

Inventor： Isin Dalkilic-Liddle ,  Benjamin A. Smith ,  Karl J.M. Hanf ,  Fang Qian ,  R. Blake Pepinsky ,  Thomas O. Cameron

IPC: C07K16/28 ,  C12N15/113

CPC classification number: C07K16/28 ,  C12N15/113 ,  C07K2317/565

Abstract: The present disclosure provides anti-transferrin receptor antibodies, compositions comprising the same and methods of their use. This disclosure also provides polynucleotides and vectors encoding the anti-transferrin receptor antibodies and cells comprising the same, methods of making the antibodies, and molecules comprising the antibodies.

公开(公告)号：US20230131379A1

公开(公告)日：2023-04-27

申请号：US17900161

申请日：2022-08-31

Applicant: Biogen MA Inc.

Inventor： Isin Dalkilic-Liddle ,  Benjamin A. Smith ,  Karl J. M. Hanf ,  Fang Qian ,  R. Blake Pepinsky ,  Thomas O. Cameron

IPC: C07K16/28 ,  C12N15/113

Abstract: The present disclosure provides anti-transferrin receptor antibodies, compositions comprising the same and methods of their use. This disclosure also provides polynucleotides and vectors encoding the anti-transferrin receptor antibodies and cells comprising the same, methods of making the antibodies, and molecules comprising the antibodies.