公开(公告)号：US09745376B2

公开(公告)日：2017-08-29

申请号：US14444701

申请日：2014-07-28

Applicant: Biogen MA Inc. ,  The Regents of the University of California

Inventor： Shelia M. Violette ,  Paul Henry Weinreb ,  Kenneth J. Simon ,  Dean Sheppard ,  Diane R. Leone

IPC: C07H21/04 ,  C12P21/06 ,  C12N15/87 ,  C12N15/74 ,  C12N1/20 ,  C07K16/28 ,  A61K47/48 ,  A61K51/10 ,  G01N33/574 ,  G01N33/68 ,  A61K39/00

CPC classification number: C07K16/2839 ,  A61K47/48507 ,  A61K47/48561 ,  A61K47/48623 ,  A61K47/68 ,  A61K47/6835 ,  A61K47/6849 ,  A61K47/6851 ,  A61K47/6865 ,  A61K51/1027 ,  A61K51/1066 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/77 ,  C07K2317/92 ,  G01N33/57492 ,  G01N33/6893 ,  G01N2333/70546 ,  G01N2800/085 ,  G01N2800/205

Abstract: Monoclonal antibodies that specifically bind to M.96. Also included are methods of using these antibodies to treat mammals having or at risk of having 006-mediated diseases, or to diagnose % Qmediated diseases.

公开(公告)号：US20170362324A1

公开(公告)日：2017-12-21

申请号：US15510422

申请日：2015-09-11

Applicant: Biogen MA Inc.

Inventor： Thomas Owen Cameron ,  Michael Adam Crackower ,  Brian M. Dolinski ,  Karl J.M. Hanf ,  Amy Theresa McCurley ,  Nels Eric Pederson ,  Martin Preyer ,  Fang Qian ,  Shelia M. Violette ,  Paul Henry Weinreb

IPC: C07K16/28

CPC classification number: C07K16/2839 ,  C07K2317/24 ,  C07K2317/41 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94

Abstract: Humanized antibodies and antibody fragments that bind to αvβ5 are disclosed. Also disclosed are methods of using the disclosed antibodies and antibody fragments to treat or prevent αvβ5-mediated diseases.