公开(公告)号：US10905681B2

公开(公告)日：2021-02-02

申请号：US16449948

申请日：2019-06-24

申请人： Biohaven Therapeutics Ltd.

发明人： Jay Edward Wrobel ,  Allen B. Reitz ,  Jefferey Claude Pelletier ,  Garry Robert Smith ,  Haiyan Bian

IPC分类号： A61K31/428 ,  A61P25/28 ,  C07D277/82 ,  A61K31/454 ,  A61K31/496 ,  A61K31/5377 ,  A61K38/05 ,  A61K45/06 ,  C07D417/12 ,  C07K5/062 ,  A61K9/00 ,  A61K9/16 ,  A61K9/20 ,  A61P25/00 ,  C07K5/083 ,  C07K5/087 ,  A61K38/06

摘要： Pharmaceutical compositions of the invention include substituted riluzole prodrugs useful for the treatment of cancers including melanoma, breast cancer, brain cancer, and prostate cancer through the release of riluzole. Prodrugs of riluzole have enhanced stability to hepatic metabolism and are delivered into systemic circulation by oral administration, and then cleaved to release riluzole in the plasma via either an enzymatic or general biophysical release process.

公开(公告)号：US20200289475A1

公开(公告)日：2020-09-17

申请号：US16449948

申请日：2019-06-24

申请人： Biohaven Therapeutics Ltd.

发明人： Jay Edward Wrobel ,  Allen B. Reitz ,  Jefferey Claude Pelletier ,  Garry Robert Smith ,  Haiyan Bian

IPC分类号： A61K31/428 ,  A61P25/00 ,  A61P25/28 ,  C07D277/82 ,  A61K31/454 ,  A61K31/496 ,  A61K31/5377 ,  A61K38/05 ,  A61K45/06 ,  C07D417/12 ,  C07K5/062 ,  A61K9/00 ,  A61K9/16 ,  A61K9/20

摘要： Pharmaceutical compositions of the invention include substituted riluzole prodrugs useful for the treatment of cancers including melanoma, breast cancer, brain cancer, and prostate cancer through the release of riluzole. Prodrugs of riluzole have enhanced stability to hepatic metabolism and are delivered into systemic circulation by oral administration, and then cleaved to release riluzole in the plasma via either an enzymatic or general biophysical release process.