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公开(公告)号：US20230330240A1
公开(公告)日：2023-10-19
申请号：US17912563
申请日：2021-03-25
发明人： Alexander Sergei BAYDEN , Tetyana BERBASOVA , Lawrence Emerson FISHER , Wieslaw KAZMIERSKI , Luca RASTELLI , Tomi K. SAWYER , David Adam SPIEGEL , Wayne Charles WIDDISON
CPC分类号： A61K47/6801 , A61K47/08 , A61K47/18 , A61P31/14
摘要： Among other things, the present disclosure provides agents that can bind to viruses such as SARS-CoV-2 and/or cells infected thereby. In some embodiments, the present disclosure provides methods for preventing and/or treating conditions, disorders or diseases associated with SARS-CoV-2 infection. In some embodiments, the present disclosure provides methods for preventing and/ or treating COVID-19.
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公开(公告)号：US20230190719A1
公开(公告)日：2023-06-22
申请号：US17923585
申请日：2021-06-23
IPC分类号： A61K31/4402 , A61K9/00 , A61K45/06 , A61K47/44
CPC分类号： A61K31/4402 , A61K9/0014 , A61K45/06 , A61K47/44
摘要： Provided is a pharmaceutical formulation including (1S)-1-phenyl-2-pyridin-2-ylethanamine, a pharmaceutically acceptable salt thereof, a solvate thereof, or a prodrug thereof; and a pharmaceutically acceptable topical carrier. Also provided is a method for treating neuropathic pain by administering to a patient in need of such treatment a therapeutically effective amount of the pharmaceutical formulation.
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公开(公告)号：US20230181541A1
公开(公告)日：2023-06-15
申请号：US17923587
申请日：2021-06-24
发明人： Vladimir CORIC , Robert BERMAN , Loren AGUIAR
IPC分类号： A61K31/428 , A61P25/18
CPC分类号： A61K31/428 , A61P25/18
摘要： Disclosed herein is a method for treating obsessive-compulsive disorder in a patient in need thereof by administering to the patient a dosage form including an effective amount of troriluzole.
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公开(公告)号：US11083711B2
公开(公告)日：2021-08-10
申请号：US16544166
申请日：2019-08-19
发明人： Anthony Marfat
IPC分类号： C07D277/82 , A61K31/428 , A61K9/14 , C07D417/12 , C07F9/6541 , A61K47/16
摘要： Disclose are amine prodrugs and methods of synthesis thereof. In particular, the amine prodrug comprises a drug molecule and at least one or more prodrug appendage moieties and the method for synthesis the amine prodrug comprises a step of coupling the drug molecule and at least one or more prodrug appendage moieties. Also disclosed are exemplary riluzole prodrugs and methods of synthesis thereof.
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公开(公告)号：US20210236471A1
公开(公告)日：2021-08-05
申请号：US17164654
申请日：2021-02-01
发明人： Jay Edward Wrobel , Allen B. Reitz , Jeffrey Claude Pelletier , Garry Robert Smith , Haiyan Bian
IPC分类号： A61K31/428 , A61P25/00 , A61P25/28 , A61K38/06 , C07K5/083 , C07K5/087 , C07D277/82 , A61K31/454 , A61K31/496 , A61K31/5377 , A61K38/05 , A61K45/06 , C07D417/12 , C07K5/062 , A61K9/00 , A61K9/16 , A61K9/20
摘要： Pharmaceutical compositions of the invention include substituted riluzole prodrugs useful for the treatment of cancers including melanoma, breast cancer, brain cancer, and prostate cancer through the release of riluzole. Prodrugs of riluzole have enhanced stability to hepatic metabolism and are delivered into systemic circulation by oral administration, and then cleaved to release riluzole in the plasma via either an enzymatic or general biophysical release process.
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公开(公告)号：US20210236470A1
公开(公告)日：2021-08-05
申请号：US17151582
申请日：2021-01-18
发明人： Jay Edward Wrobel , Allen B. Reitz , Jeffrey Claude Pelletier , Garry Robert Smith , Haiyan Bian
IPC分类号： A61K31/428 , A61P25/00 , A61P25/28 , A61K38/06 , C07K5/083 , C07K5/087 , C07D277/82 , A61K31/454 , A61K31/496 , A61K31/5377 , A61K38/05 , A61K45/06 , C07D417/12 , C07K5/062 , A61K9/00 , A61K9/16 , A61K9/20
摘要： Pharmaceutical compositions of the invention include substituted riluzole prodrugs useful for the treatment of cancers including melanoma, breast cancer, brain cancer, and prostate cancer through the release of riluzole. Prodrugs of riluzole have enhanced stability to hepatic metabolism and are delivered into systemic circulation by oral administration, and then cleaved to release riluzole in the plasma via either an enzymatic or general biophysical release process.
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公开(公告)号：US20240252674A1
公开(公告)日：2024-08-01
申请号：US18555857
申请日：2022-05-17
CPC分类号： A61K47/6889 , A61K47/64 , A61K47/6835
摘要： Among other things, the present disclosure provides technologies for site-directed conjugation of various moieties of interest to target agents. In some embodiments, the present disclosure utilizes target binding moieties to provide high conjugation efficiency and selectivity. In some embodiments, provided technologies are useful for preparing antibody conjugates.
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公开(公告)号：US20240238436A1
公开(公告)日：2024-07-18
申请号：US18555855
申请日：2022-05-17
CPC分类号： A61K47/6811 , A61K45/06 , A61K47/64 , A61K47/6843 , A61K47/6889 , C07K7/06 , C07K16/18
摘要： A composition including a first compound having the structure P-N-LPM-MOI, wherein P-N is a protein agent moiety comprising a lysine residue, LPM is a linker, and MOI is a moiety of interest, and a second compound having the structure LG-OH, wherein LG is a group comprising a target binding moiety that binds to a target agent.
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公开(公告)号：US11834418B2
公开(公告)日：2023-12-05
申请号：US17127231
申请日：2020-12-18
发明人： Lynn Resnick , George T. Topalov , Justin K. Belardi , James S. Hale , Scott S. Harried , Charles A. Flentge , David A. Mareska
IPC分类号： C07D235/30 , C07D413/04 , C07D401/04 , C07D405/12 , C07D403/04 , C07D401/12
CPC分类号： C07D235/30 , C07D401/04 , C07D401/12 , C07D403/04 , C07D405/12 , C07D413/04
摘要： Optionally substituted benzoimidazol-1,2-yl amides, such as compounds of Formula 1 or Formula 2, can be used to treat disorders associated with a Kv7 potassium channel activator. Compositions, medicaments, and dosage forms related to the treatment are also disclosed herein.
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公开(公告)号：US20230028880A1
公开(公告)日：2023-01-26
申请号：US17623238
申请日：2020-06-24
摘要： Among other things, the present disclosure provides compounds comprising antibody binding moieties and CD38-binding targeting moieties. In some embodiments, provided compounds recruit various types of antibodies to diseased cells such as cancer cells, and induce immune activities to kill such cells. Provided technologies are useful for treating various diseases including cancer.
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