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    METHOD FOR THE PREPARATION OF PLYMERS WITH VARIED ARCHTECTURE AND AMIDE INITIATION
    9.
    发明申请
    METHOD FOR THE PREPARATION OF PLYMERS WITH VARIED ARCHTECTURE AND AMIDE INITIATION 审中-公开
    用于制备具有变化的结构和氨基酸启动的聚合物的方法

    公开(公告)号：US20130317121A1

    公开(公告)日：2013-11-28

    申请号：US13885654

    申请日：2011-11-14

    申请人： Didier Bourissou ,  Blanca Martin-Vaca ,  Aurélie Alba ,  Roland Cherif-Cheikh ,  Anne-Paula De Sousa Delgado

    发明人： Didier Bourissou ,  Blanca Martin-Vaca ,  Aurélie Alba ,  Roland Cherif-Cheikh ,  Anne-Paula De Sousa Delgado

    IPC分类号： A61K47/34

    CPC分类号： A61K47/34 ,  C08G63/08 ,  C08G63/6852 ,  C08G63/81 ,  C08G63/823

    摘要： The invention relates to a method for preparing linear polymers having an amide end or having a star architecture comprising an amide core, by means of a ring opening using lactide and glycolide monomers or a lactide monomer ring in the presence of a catalyst, wherein the method includes the steps of: (i) reacting the excess monomer(s) with an initiator in a solvent, said initiator being selected from among an amine and an amino alcohol, given that the initiator has at least one primary or secondary amine function; (ii) adding a catalyst, said catalyst being a non-nucleophilic base and including at least one neutral sp2 nitrogen atom; and (iii) neutralizing the reaction mixture. Said novel method is particularly advantageous in that it can be easily monitored and enables better modulation of the polymers, and thus of the properties thereof, than the methods of the prior art. The invention also relates to novel polymers that are obtainable by means of said method.

    摘要翻译： 本发明涉及一种通过在催化剂存在下通过使用丙交酯和乙交酯单体或丙交酯单体环的开环制备具有酰胺末端或具有包含酰胺核心的星型结构的线性聚合物的方法，其中所述方法 包括以下步骤：（i）使多余的单体与引发剂在溶剂中反应，所述引发剂选自胺和氨基醇，假定引发剂具有至少一个伯或仲胺官能团; （ii）加入催化剂，所述催化剂是非亲核碱，并包括至少一个中性sp2氮原子; 和（iii）中和反应混合物。 所述新颖的方法特别有利的是，与现有技术的方法相比，其可以容易地被监测并且能够更好地调节聚合物，并因此实现其性质。 本发明还涉及通过所述方法可获得的新型聚合物。