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公开(公告)号：US11236086B2
公开(公告)日：2022-02-01
申请号：US16754184
申请日：2018-10-18
IPC分类号： C07D471/04 , C07D519/00
摘要： Described herein are compounds that inhibit ALK2 and its mutants, pharmaceutical compositions including such compounds, and methods of using such compounds and compositions.
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公开(公告)号：US20170298069A1
公开(公告)日：2017-10-19
申请号：US15488257
申请日：2017-04-14
发明人： Natasja Brooijmans , Jason D. Brubaker , Mark Cronin , Paul E. Fleming , Brian L. Hodous , Joseph L. Kim , Josh Waetzig , Brett Williams , Douglas Wilson , Kevin J. Wilson
IPC分类号： C07D487/04 , C07D519/00
CPC分类号： C07D487/04 , C07D519/00
摘要： Described herein are compounds that inhibit ALK2 and its mutants, pharmaceutical compositions including such compounds, and methods of using such compounds and compositions.
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公开(公告)号：US20240158398A1
公开(公告)日：2024-05-16
申请号：US18137228
申请日：2023-04-20
发明人： Natasja Brooijmans , Jason D. Brubaker , Paul E. Fleming , Brian Lewis Hodous , Joseph L. Kim , Brett D. Williams , Douglas Wilson , Kevin J. Wilson , Mark Cronin
IPC分类号： C07D487/04 , A61K31/5025 , A61K31/5377 , A61K31/5383 , A61P35/00 , C07D519/00
CPC分类号： C07D487/04 , A61K31/5025 , A61K31/5377 , A61K31/5383 , A61P35/00 , C07D519/00
摘要： Described herein are compounds that inhibit ALK2 and its mutants, pharmaceutical compositions including such compounds, and methods of using such compounds and compositions.
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公开(公告)号：US20200331908A1
公开(公告)日：2020-10-22
申请号：US16754184
申请日：2018-10-18
IPC分类号： C07D471/04 , C07D519/00
摘要： Described herein are compounds that inhibit ALK2 and its mutants, pharmaceutical compositions including such compounds, and methods of using such compounds and compositions.
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公开(公告)号：US10233186B2
公开(公告)日：2019-03-19
申请号：US15488257
申请日：2017-04-14
发明人： Natasja Brooijmans , Jason D. Brubaker , Mark Cronin , Paul E. Fleming , Brian L. Hodous , Joseph L. Kim , Brett Williams , Douglas Wilson , Kevin J. Wilson
IPC分类号： C07D487/04 , C07D519/00
摘要： Described herein are compounds, such as compounds of formula (I) and pharmaceutically acceptable salts thereof, that inhibit ALK2 and its mutants, pharmaceutical compositions including such compounds, and methods of using such compounds and compositions
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公开(公告)号：US10227329B2
公开(公告)日：2019-03-12
申请号：US15657057
申请日：2017-07-21
发明人： Jason D. Brubaker , Timothy Guzi , Kevin J. Wilson , Lucian V. Dipietro , Yulian Zhang , Douglas Wilson , Paul E. Fleming
IPC分类号： C07D401/14
摘要： Described herein are compounds that inhibit wild-type RET and its resistant mutants, pharmaceutical compositions including such compounds, and methods of using such compounds and compositions.
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公开(公告)号：US10202365B2
公开(公告)日：2019-02-12
申请号：US15548925
申请日：2016-02-05
发明人： Natasja Brooijmans , Lucian V. DiPietro , Paul E. Fleming , Joseph L. Kim , Steven Mark Wenglowsky , Yulian Zhang
IPC分类号： A61K31/506 , C07D401/14 , C07D403/12 , C07D405/14 , C07D403/04 , C07D417/14 , A61K45/06
摘要： Described herein are compounds, such as compounds of Formula (I) and pharmaceutically acceptable salts thereof, that inhibit wild-type RET and its resistant mutants, pharmaceutical compositions including such compounds, and methods of using such compounds and compositions, e.g., for treating a condition mediated by aberrant RET activity
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公开(公告)号：US11634422B2
公开(公告)日：2023-04-25
申请号：US16887262
申请日：2020-05-29
发明人： Natasja Brooijmans , Jason D. Brubaker , Paul E. Fleming , Brian Lewis Hodous , Joseph L. Kim , Brett D. Williams , Douglas Wilson , Kevin J. Wilson , Mark Cronin
IPC分类号： A61P35/00 , A61K31/5025 , A61K31/5377 , A61K31/5383 , C07D487/04 , C07D519/00
摘要： Described herein are compounds that inhibit ALK2 and its mutants, pharmaceutical compositions including such compounds, and methods of using such compounds and compositions.
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公开(公告)号：US20220315585A1
公开(公告)日：2022-10-06
申请号：US16887262
申请日：2020-05-29
发明人： Natasja Brooijmans , Jason D. Brubaker , Paul E. Fleming , Brian L. Hodous , Joseph L. Kim , Josh Waetzig , Brett Williams , Douglas Wilson , Kevin J. Wilson , Mark Cronin
IPC分类号： C07D487/04 , C07D519/00
摘要： Described herein are compounds that inhibit ALK2 and its mutants, pharmaceutical compositions including such compounds, and methods of using such compounds and compositions.
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公开(公告)号：US10774070B2
公开(公告)日：2020-09-15
申请号：US16228381
申请日：2018-12-20
发明人： Natasja Brooijmans , Lucian V. DiPietro , Paul E. Fleming , Joseph L. Kim , Steven Mark Wenglowsky , Yulian Zhang
IPC分类号： A61K31/506 , C07D401/14 , C07D403/12 , C07D405/14 , C07D403/04 , C07D417/14 , A61K45/06
摘要： Described herein are compounds, such as compounds of Formula (I) and pharmaceutically acceptable salts thereof, that inhibit wild-type RET and its resistant mutants, pharmaceutical compositions including such compounds, and methods of using such compounds and compositions, e.g., for treating a condition mediated by aberrant RET activity
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