公开(公告)号：US11325898B2

公开(公告)日：2022-05-10

申请号：US17112980

申请日：2020-12-04

申请人： Board of Regents, The University of Texas System

发明人： Jef De Brabander ,  Qiren Liang ,  Beth Levine ,  Wei-Chung Chiang

IPC分类号： C07D405/04 ,  C07D405/14 ,  C07D231/06 ,  C07D403/04 ,  C07D231/12 ,  C07D401/04 ,  C07D413/10 ,  C07D413/04 ,  C07D409/04 ,  C07D405/06 ,  C07D417/04 ,  C07D405/12

摘要： Small molecule disruptors of Beclin-1/Bcl-2 protein-protein interactions induce autophagy and hence are useful for treating a variety of indications where stimulation of autophagy is therapeutically useful, including cancer, infection immunity, neurodegeneration, longevity.

公开(公告)号：US20210115024A1

公开(公告)日：2021-04-22

申请号：US17112980

申请日：2020-12-04

申请人： Board of Regents, The University of Texas System

发明人： Jef De Brabander ,  Qiren Liang ,  Beth Levine ,  Wei-Chung Chiang

IPC分类号： C07D405/04 ,  C07D405/14 ,  C07D231/06 ,  C07D403/04 ,  C07D231/12 ,  C07D401/04 ,  C07D413/10 ,  C07D413/04 ,  C07D409/04 ,  C07D405/12 ,  C07D405/06 ,  C07D417/04

摘要： Small molecule disruptors of Beclin-1/Bcl-2 protein-protein interactions induce autophagy and hence are useful for treating a variety of indications where stimulation of autophagy is therapeutically useful, including cancer, infection immunity, neurodegeneration, longevity.

公开(公告)号：US20220242854A1

公开(公告)日：2022-08-04

申请号：US17714131

申请日：2022-04-05

申请人： Board of Regents, The University of Texas System

发明人： Jef De Brabander ,  Qiren Liang ,  Beth Levine ,  Wei-Chung Chiang

IPC分类号： C07D405/04 ,  C07D231/06 ,  C07D231/12 ,  C07D401/04 ,  C07D403/04 ,  C07D405/06 ,  C07D405/12 ,  C07D405/14 ,  C07D409/04 ,  C07D413/04 ,  C07D413/10 ,  C07D417/04

摘要： Small molecule disruptors of Beclin-1/Bc1-2 protein-protein interactions induce autophagy and hence are useful for treating a variety of indications where stimulation of autophagy is therapeutically useful, including cancer, infection immunity, neurodegeneration, longevity.

公开(公告)号：US20230203020A1

公开(公告)日：2023-06-29

申请号：US18167835

申请日：2023-02-11

申请人： Board of Regents, The University of Texas System

发明人： Jef De Brabander ,  Qiren Liang ,  Beth Levine ,  Wei-Chung Chiang

IPC分类号： C07D405/04 ,  C07D231/06 ,  C07D231/12 ,  C07D401/04 ,  C07D403/04 ,  C07D405/06 ,  C07D405/12 ,  C07D405/14 ,  C07D409/04 ,  C07D413/04 ,  C07D413/10 ,  C07D417/04

CPC分类号： C07D405/04 ,  C07D231/06 ,  C07D231/12 ,  C07D401/04 ,  C07D403/04 ,  C07D405/06 ,  C07D405/12 ,  C07D405/14 ,  C07D409/04 ,  C07D413/04 ,  C07D413/10 ,  C07D417/04

摘要： Small molecule disruptors of Beclin-1/Bcl-2 protein-protein interactions induce autophagy and hence are useful for treating a variety of indications where stimulation of autophagy is therapeutically useful, including cancer, infection immunity, neurodegeneration, longevity.

公开(公告)号：US11591319B2

公开(公告)日：2023-02-28

申请号：US17714131

申请日：2022-04-05

申请人： Board of Regents, The University of Texas System

发明人： Jef De Brabander ,  Qiren Liang ,  Beth Levine ,  Wei-Chung Chiang

IPC分类号： C07D405/04 ,  C07D231/06 ,  C07D231/12 ,  C07D401/04 ,  C07D403/04 ,  C07D405/06 ,  C07D405/12 ,  C07D405/14 ,  C07D413/04 ,  C07D413/10 ,  C07D417/04 ,  C07D409/04

摘要： Small molecule disruptors of Beclin-1/Bc1-2 protein-protein interactions induce autophagy and hence are useful for treating a variety of indications where stimulation of autophagy is therapeutically useful, including cancer, infection immunity, neurodegeneration, longevity.