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公开(公告)号:US09474730B2
公开(公告)日:2016-10-25
申请号:US13873799
申请日:2013-04-30
IPC分类号: A61K31/135 , A01N33/02 , C07C211/00 , A61K31/137 , C12Q1/48 , G01N33/50 , A61K45/06
CPC分类号: A61K31/137 , A61K45/06 , C12Q1/485 , G01N33/5011 , G01N2333/82
摘要: Methods and compositions that can be used to identify and characterize inhibitors of K-ras localization to the plasma membrane and in doing so inhibit the signal transduction of K-ras. Such compositions can be used to treat K-ras mediated disorders, such as cancer.
摘要翻译: 可用于鉴定和表征K-ras对质膜定位的抑制剂的方法和组合物,因此抑制K-ras的信号转导。 这样的组合物可用于治疗K-ras介导的疾病,例如癌症。