公开(公告)号：US20200297756A1

公开(公告)日：2020-09-24

申请号：US16898460

申请日：2020-06-11

申请人： Board of Supervisors of Louisiana State University and Agricultural and Mechanical College

发明人： Christopher KEVIL ,  Anthony GIORDANO ,  Douglas R. FLANAGAN ,  Panayiotis P. CONSTANTINIDES

IPC分类号： A61K33/00 ,  A61K9/20 ,  A61K9/28 ,  A61K9/50 ,  A61K9/00

摘要： The present invention relates to pharmaceutical compositions of nitrites such as inorganic nitrites, or any pharmaceutically acceptable salts, solvates, or prodrugs thereof, and the medical use of these compositions. The pharmaceutical compositions, which can be formulated for oral administration, can provide immediate release or extended release of the nitrite ion (NO2−). The pharmaceutical compositions of the invention are useful, for example, for the treatment of chronic tissue ischemia.

公开(公告)号：US20200085861A1

公开(公告)日：2020-03-19

申请号：US16599710

申请日：2019-10-11

申请人： Board of Supervisors of Louisiana State University and Agricultural and Mechanical College

发明人： Christopher KEVIL ,  Anthony GIORDANO ,  Douglas R. FLANAGAN ,  Panayiotis P. CONSTANTINIDES

IPC分类号： A61K33/00 ,  A61K9/20 ,  A61K9/28 ,  A61K9/50 ,  A61K9/00

摘要： The present invention relates to pharmaceutical compositions of nitrites such as inorganic nitrites, or any pharmaceutically acceptable salts, solvates, or prodrugs thereof, and the medical use of these compositions. The pharmaceutical compositions, which can be formulated for oral administration, can provide immediate release or extended release of the nitrite ion (NO2−). The pharmaceutical compositions of the invention are useful, for example, for the treatment of chronic tissue ischemia.

公开(公告)号：US20170087180A1

公开(公告)日：2017-03-30

申请号：US15315651

申请日：2015-06-02

申请人： Sulfagenix, Inc. ,  The Board of Supervisors of Louisiana State University and Agricultural and Mechanical College

发明人： Anthony GIORDANO ,  David J. LEFER

IPC分类号： A61K33/04 ,  A61K9/00 ,  A61K45/06 ,  A61K9/48

CPC分类号： A61K33/04 ,  A61K9/0014 ,  A61K9/48 ,  A61K33/06 ,  A61K33/30 ,  A61K45/06 ,  A61P3/06 ,  A61P3/10 ,  A61P9/00 ,  A61P9/10 ,  A61P25/28 ,  A61P29/00 ,  A61P35/00 ,  A61K2300/00

摘要： The present invention relates to sulfur compositions which are useful, for example, for treating a NO deficiency disorder, supplementing deficits in circulating nitrite, and/or improving bodily endurance or exercise performance.

公开(公告)号：US20220169508A1

公开(公告)日：2022-06-02

申请号：US17671540

申请日：2022-02-14

申请人： Board of Supervisors of Louisiana State University and Agricultural and Mechanical College

发明人： Amol SOIN ,  Christopher KEVIL ,  Kyle CHAN ,  Anthony GIORDANO

IPC分类号： C01B21/50 ,  A61K31/381 ,  A61K31/095 ,  A61K31/137 ,  A61K31/445 ,  A61P25/02 ,  A61K33/00

摘要： The present invention relates to pharmaceutical compositions of nitrites such as inorganic nitrites, or any pharmaceutically acceptable salts, solvates, or prodrugs thereof, and the medical use of these compositions. The pharmaceutical compositions, which can be formulated for oral administration, can provide immediate release or extended release of the nitrite ion (NO2−). The pharmaceutical compositions of the invention are useful, for example, for treating or reducing pain, improving symptoms of a microvascular disease, and improving nerve conduction velocity.