专利检索 ap:("Board of Supervisors of Louisiana State University AND Agricultural AND Mechanical College") AND inv:"Dennis J. Paul" 第 1 页

1.

发明申请
TARGETED OSMOTIC LYSIS OF MALIGNANT CANCER CELLS USING PULSED MAGNETIC FIELD GRADIENTS 审中-公开

公开(公告)号：US20200147405A1

公开(公告)日：2020-05-14

申请号：US16632034

申请日：2018-07-12

申请人： Board of Supervisors of Louisiana State University and Agricultural and Mechanical College

发明人： Dennis J. Paul , Harry J. Gould, III

IPC分类号： A61N2/02 , A61B5/05 , A61K31/7048 , A61K31/352 , A61P35/00

摘要： Methods are provided for targeting cancer cells that over-express voltage-gated sodium channels (VGSCs or “sodium channels”) and causing osmotic lysis of these cancer cells by initially inhibiting the sodium, potassium-adenosine triphosphatase (Na+, K+-ATPase or “sodium pump”), and then stimulating the VGSCs by pulsed magnetic field gradients to cause sodium and water to enter the cancer cells.

2.

发明授权
Targeted osmotic lysis of malignant cancer cells using pulsed magnetic field gradients 有权

公开(公告)号：US11654292B2

公开(公告)日：2023-05-23

申请号：US16632034

申请日：2018-07-12

申请人： Board of Supervisors of Louisiana State University and Agricultural and Mechanical College

发明人： Dennis J. Paul , Harry J. Gould, III

IPC分类号： A61N2/02 , A61B5/05 , A61P35/00 , A61K31/352 , A61K31/7048

CPC分类号： A61N2/02 , A61B5/05 , A61K31/352 , A61K31/7048 , A61P35/00

摘要： Methods are provided for targeting cancer cells that over-express voltage-gated sodium channels (VGSCs or “sodium channels”) and causing osmotic lysis of these cancer cells by initially inhibiting the sodium, potassium-adenosine triphosphatase (Na+, K+-ATPase or “sodium pump”), and then stimulating the VGSCs by pulsed magnetic field gradients to cause sodium and water to enter the cancer cells.

3.

发明申请
METHOD AND SYSTEM FOR APPLYING PULSED ELECTRIC FIELDS WITH HIGH UNIFORMITY USING MAGNETIC CORES 有权

公开(公告)号：US20220072324A1

公开(公告)日：2022-03-10

申请号：US17299838

申请日：2019-12-02

申请人： Board of Supervisors of Louisiana State University and Agricultural and Mechanical College , The Phantom Laboratory, Incorporated

发明人： Dennis J. Paul , Harry J. Gould , Richard Philip Mallozzi

IPC分类号： A61N1/40 , H01F7/20 , H01F7/06

摘要： A device, system and method for creating pulsed electric fields with good uniformity are provided. The electric fields occupy a large volume, suitable for placing a human or animal patient. A device for generating the electric fields is provided, which comprises one or more toroidally or cylindrically shaped magnetic core(s) wound with electrical wires, which, when pulsed with electrical currents, generate an electric field of high uniformity in the interior region of the toroidal or cylindrical cores. These electric field pulses, when used in conjunction with pharmacological agent, destroy cancer cells through a process called Targeted Osmotic Lysis.