公开(公告)号：US11957746B2

公开(公告)日：2024-04-16

申请号：US16980785

申请日：2019-03-25

申请人： Boehringer Ingelheim Animal Health USA Inc.

发明人： Leigh Wilmes ,  Matthew Coons ,  Amanda Brown ,  Michael Johannes Gassel ,  Francois-Xavier Orveillon ,  Katharina Hedwig Toepfer ,  Elida Bautista ,  Kathy Schlesinger

IPC分类号： A61K39/12 ,  A61P31/20 ,  C12N15/86 ,  A61K39/00

CPC分类号： A61K39/12 ,  A61P31/20 ,  C12N15/86 ,  A61K2039/523 ,  A61K2039/5252 ,  A61K2039/5256 ,  A61K2039/5258 ,  C12N2710/14034 ,  C12N2710/14042 ,  C12N2710/14062

摘要： The present invention in particular relates to a method of producing an immunogenic composition exhibiting reduced virucidal activity, as well as to the immunogenic composition and uses thereof, wherein the method in particular comprises the steps of: (a) providing a mixture with a first liquid and a recombinant protein, (b) concentrating the recombinant protein in the mixture by removing a portion of the first liquid from the mixture, and (c) processing the solution resulting from step (b) by continuous diafiltration.