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公开(公告)号：US20190263828A1
公开(公告)日：2019-08-29
申请号：US16410037
申请日：2019-05-13
发明人： Todd BOSANAC , Michael J. BURKE , Brian Nicholas COOK , Darren Todd DISALVO , Thomas Martin KIRRANE, JR. , Yue SHEN
IPC分类号： C07D498/04 , C07D519/00 , C07D498/10
摘要： The present invention encompasses compounds of the formula (I) wherein the groups A and B are defined herein, which are suitable for the treatment of diseases related to Vanin, and processes for making these compounds, pharmaceutical preparations containing these compounds, and their methods of use.
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公开(公告)号：US20160340339A1
公开(公告)日：2016-11-24
申请号：US15114923
申请日：2015-01-23
发明人： Joerg BENTZIEN , Angela Kay BERRY , Todd BOSANAC , Michael Jason BURKE , Darren Todd DISALVO , Can MAO , Wang MAO , Yue SHEN
IPC分类号： C07D403/04 , C07D401/04
CPC分类号： C07D403/04 , C07D401/04 , C07D401/10 , C07D403/10
摘要： The present invention encompasses compounds of the formula (I) wherein the groups R1, Cy, and Y are defined herein, which are suitable for the treatment of diseases related to BTK, process of making, pharmaceutical preparations which contain compounds and their methods of use.
摘要翻译： 本发明包括式（I）化合物，其中R1，Cy和Y基团在本文中定义，其适用于治疗与BTK相关的疾病，制备方法，含有化合物的药物制剂及其使用方法 。
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公开(公告)号：US20160031872A1
公开(公告)日：2016-02-04
申请号：US14884826
申请日：2015-10-16
发明人： Joerg Martin BENTZIEN , Angela Kay BERRY , Todd BOSANAC , Michael Jason BURKE , Darren Todd DISALVO , Joshua Courtney HORAN , Shuang LIANG , Can MAO , Wang MAO , Yue SHEN , Fariba SOLEYMANZADEH , Renee M. ZINDELL
IPC分类号： C07D417/08 , C07D401/02 , C07D231/40 , C07D231/38 , C07D401/04 , C07D403/08
CPC分类号： C07D417/08 , C07D231/14 , C07D231/38 , C07D231/40 , C07D277/56 , C07D401/02 , C07D401/04 , C07D401/06 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/08 , C07D405/14 , C07D413/14 , C07D417/02 , C07D417/04 , C07D417/06
摘要： The present invention encompasses compounds of the formula (I) wherein the groups A, Cy, X1 and Y are defined herein, which are suitable for the treatment of diseases related to BTK, process of making, pharmaceutical preparations which contain compounds and their methods of use.
摘要翻译： 本发明包括其中本文定义的基团A，Cy，X 1和Y的式（I）的化合物，其适用于治疗与BTK相关的疾病，制备方法，含有化合物的药物制剂及其方法 使用。
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公开(公告)号：US20180086748A1
公开(公告)日：2018-03-29
申请号：US15814927
申请日：2017-11-16
发明人： Joerg BENTZIEN , Angela Kay BERRY , Todd BOSANAC , Michael Jason BURKE , Darren Todd DISALVO , Joshua Courtney HORAN , Shuang LIANG , Can MAO , Wang MAO , Yue SHEN , Fariba SOLEYMANZADEH , Renee M. ZINDELL
IPC分类号： C07D417/08 , C07D417/06 , C07D231/14 , C07D417/02 , C07D413/14 , C07D405/14 , C07D403/08 , C07D403/06 , C07D403/04 , C07D401/14 , C07D401/06 , C07D401/04 , C07D401/02 , C07D277/56 , C07D231/40 , C07D231/38 , C07D417/04
CPC分类号： C07D417/08 , C07D231/14 , C07D231/38 , C07D231/40 , C07D277/56 , C07D401/02 , C07D401/04 , C07D401/06 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/08 , C07D405/14 , C07D413/14 , C07D417/02 , C07D417/04 , C07D417/06
摘要： The present invention encompasses compounds of the formula (I) wherein the groups A, Cy, X1 and Y are defined herein, which are suitable for the treatment of diseases related to BTK, process of making, pharmaceutical preparations which contain compounds and their methods of use.
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公开(公告)号：US20170320867A1
公开(公告)日：2017-11-09
申请号：US15661644
申请日：2017-07-27
发明人： Joerg Martin BENTZIEN , Angela Kay BERRY , Todd BOSANAC , Michael Jason BURKE , Darren Todd DISALVO , Joshua Courtney HORAN , Shuang LIANG , Can MAO , Wang MAO , Yue SHEN , Fariba SOLEYMANZADEH , Renee M. ZINDELL
IPC分类号： C07D417/08 , C07D231/14 , C07D417/02 , C07D413/14 , C07D405/14 , C07D403/08 , C07D403/06 , C07D403/04 , C07D401/14 , C07D401/06 , C07D401/04 , C07D401/02 , C07D277/56 , C07D231/40 , C07D231/38 , C07D417/04 , C07D417/06
CPC分类号： C07D417/08 , C07D231/14 , C07D231/38 , C07D231/40 , C07D277/56 , C07D401/02 , C07D401/04 , C07D401/06 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/08 , C07D405/14 , C07D413/14 , C07D417/02 , C07D417/04 , C07D417/06
摘要： The present invention encompasses compounds of the formula (I) wherein the groups A, Cy, X1 and Y are defined herein, which are suitable for the treatment of diseases related to BTK, process of making, pharmaceutical preparations which contain compounds and their methods of use.
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公开(公告)号：US20190112302A1
公开(公告)日：2019-04-18
申请号：US16160048
申请日：2018-10-15
发明人： Joerg BENTZIEN , Angela Kay BERRY , Todd BOSANAC , Michael Jason BURKE , Darren Todd DISALVO , Joshua Courtney HORAN , Shuang LIANG , Can MAO , Wang MAO , Yue SHEN , Fariba SOLEYMANZADEH , Renee M. ZINDELL
IPC分类号： C07D417/08 , C07D403/08 , C07D413/14 , C07D231/40 , C07D417/04 , C07D231/14 , C07D417/02 , C07D231/38 , C07D403/04 , C07D277/56 , C07D401/04 , C07D401/06 , C07D401/14 , C07D417/06 , C07D403/06 , C07D405/14 , C07D401/02
摘要： The present invention encompasses compounds of the formula (I) wherein the groups A, Cy, X1 and Y are defined herein, which are suitable for the treatment of diseases related to BTK, process of making, pharmaceutical preparations which contain compounds and their methods of use.
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公开(公告)号：US20190023686A1
公开(公告)日：2019-01-24
申请号：US16069046
申请日：2017-01-12
申请人： Todd BOSANAC , Joerg BENTZIEN , Michael Jason BURKE , Darren Todd DISALVO , Wang MAO , Fariba SOLEYMANZADEH , John WESTBROOK , Zhaoming XIONG , Boehringer Ingelheim International GmbH
发明人： Todd BOSANAC , Joerg BENTZIEN , Michael Jason BURKE , Darren Todd DISALVO , Wang MAO , Fariba SOLEYMANZADEH , John A. WESTBROOK , Zhaoming XIONG
IPC分类号： C07D401/14
摘要： The present invention encompasses compounds of the formula (I) wherein the groups R1, R2, R3, R4 and R5 are defined herein, which are suitable for the treatment of diseases related to Bruton's tyrosine kinase (BTK), and processes for making these compounds, pharmaceutical preparations containing these compounds, and their methods of use.
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公开(公告)号：US20180354968A1
公开(公告)日：2018-12-13
申请号：US16003252
申请日：2018-06-08
发明人： Todd BOSANAC , Michael J. BURKE , Brian Nicholas COOK , Darren Todd DISALVO , Thomas Martin KIRRANE, JR. , Yue SHEN
IPC分类号： C07D498/04 , C07D498/10 , C07D519/00
CPC分类号： C07D498/04 , C07D498/10 , C07D519/00
摘要： The present invention encompasses compounds of the formula (I) wherein the groups A and B are defined herein, which are suitable for the treatment of diseases related to Vanin, and processes for making these compounds, pharmaceutical preparations containing these compounds, and their methods of use.
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