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公开(公告)号：US11578080B2
公开(公告)日：2023-02-14
申请号：US17463942
申请日：2021-09-01
发明人： Martin Thomas Fleck , Florian Paul Christian Binder , Georg Dahmann , Joerg P. Hehn , Annekatrin Charlotte Heimann , Uta Friederike Lessel , Jens Willwacher
IPC分类号： C07D495/04 , C07D495/14
摘要： This invention relates to thienopyrimidinones and their use as inhibitors of TRPA1 activity, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of fibrotic diseases, inflammatory and auto-immune diseases and CNS-related diseases.
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公开(公告)号：US11661427B2
公开(公告)日：2023-05-30
申请号：US17500133
申请日：2021-10-13
IPC分类号： C07D491/048
CPC分类号： C07D491/048
摘要： The present disclosure provides certain tetrazole derivatives that are inhibitors of transient receptor potential ankyrin 1 (TRPA1), and are therefore useful for the treatment of diseases treatable by inhibition of TRPA1. Also provided are pharmaceutical compositions containing the same, and processes for preparing the same.
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公开(公告)号：US11858921B2
公开(公告)日：2024-01-02
申请号：US17719433
申请日：2022-04-13
IPC分类号： C07D413/08 , C07D413/14 , A61K31/427 , A61P29/00
CPC分类号： C07D413/08 , C07D413/14
摘要： The present disclosure provides certain uracil derivatives that are inhibitors of transient receptor potential ankyrin 1 (TRPA1), and are therefore useful for the treatment of diseases treatable by inhibition of TRPA1. Also provided are pharmaceutical compositions containing the same, and processes for preparing said compounds.
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公开(公告)号：US11661430B2
公开(公告)日：2023-05-30
申请号：US17500215
申请日：2021-10-13
IPC分类号： C07D495/04
CPC分类号： C07D495/04
摘要： The present disclosure provides certain tetrazole derivatives that are inhibitors of transient receptor potential ankyrin 1 (TRPA1), and are therefore useful for the treatment of diseases treatable by inhibition of TRPA1. Also provided are pharmaceutical compositions containing the same, and processes for preparing the same.
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公开(公告)号：US11891403B2
公开(公告)日：2024-02-06
申请号：US17356782
申请日：2021-06-24
IPC分类号： C07D498/04 , C07D471/04 , C07D513/04
CPC分类号： C07D498/04 , C07D471/04 , C07D513/04
摘要： The present disclosure provides certain tetrazole derivatives that are inhibitors of transient receptor potential ankyrin 1 (TRPA1), and are therefore useful for the treatment of diseases treatable by inhibition of TRPA1. Also provided are pharmaceutical compositions containing the same, and processes for preparing said compounds.
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公开(公告)号：US11884652B2
公开(公告)日：2024-01-30
申请号：US17356748
申请日：2021-06-24
IPC分类号： C07D403/06 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14
CPC分类号： C07D403/06 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14
摘要： The present disclosure provides certain tetrazole derivatives that are inhibitors of transient receptor potential ankyrin 1 (TRPA1), and are therefore useful for the treatment of diseases treatable by inhibition of TRPA1. Also provided are pharmaceutical compositions containing the same, and processes for preparing said compounds.
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公开(公告)号：US11136336B2
公开(公告)日：2021-10-05
申请号：US17071081
申请日：2020-10-15
发明人： Martin Thomas Fleck , Florian Paul Christian Binder , Georg Dahmann , Joerg P. Hehn , Annekatrin Charlotte Heimann , Jens Willwacher
IPC分类号： C07D495/04 , C07D495/14
摘要： This invention relates to thienopyrimidinones and their use as inhibitors of TRPA1 activity, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of fibrotic diseases, inflammatory and auto-immune diseases and CNS-related diseases.
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