公开(公告)号：US20230340028A1

公开(公告)日：2023-10-26

申请号：US18059171

申请日：2022-11-28

申请人： Boehringer Ingelheim Vetmedica GmbH

发明人： Annika KRAEMER-KUEHL ,  Thomas Min STEPHAN ,  Hans-Christian PHILIPP

IPC分类号： C07K14/005 ,  C12N7/00 ,  C12N15/85 ,  A61P31/14 ,  A61K39/215

CPC分类号： C07K14/005 ,  C12N7/00 ,  C12N15/85 ,  A61P31/14 ,  A61K39/215 ,  C12N2770/20023 ,  C12N2770/20022 ,  C12N2800/10

摘要： The present invention relates i.a. to a recombinant avian coronavirus spike protein or fragment thereof comprising a mutation at amino acid position 267 to Cysteine. Further, the present invention relates to an immunogenic composition comprising an avian coronavirus with such spike protein.