公开(公告)号：US20220257297A1

公开(公告)日：2022-08-18

申请号：US17668908

申请日：2022-02-10

Applicant: Boston Scientific Scimed Inc

Inventor： Brendan E. Koop ,  Allan C. Shuros ,  Jonathan T. Gorzycki

IPC: A61B18/00 ,  A61M25/00

Abstract: An electroporation ablation system for treating targeted tissue in a patient. The electroporation ablation system including an ablation catheter and an electroporation generator. The ablation catheter including a handle, a shaft having a distal end, and catheter electrodes situated at the distal end of the shaft and spatially arranged to generate electric fields in the targeted tissue in response to electrical pulses. The electroporation generator operatively coupled to the catheter electrodes and configured to deliver the electrical pulses in an electroporation pulse sequence to one or more catheter electrodes. Wherein, the electroporation pulse sequence includes multiple pulse bursts, and each of the multiple pulse bursts includes pulses separated by an inter-pulse length of between 200 and 350 microseconds to reduce muscle stimulation while creating electroporation lesions.

公开(公告)号：US20220022952A1

公开(公告)日：2022-01-27

申请号：US17381953

申请日：2021-07-21

Applicant: Boston Scientific Scimed Inc

Inventor： Brendan E. Koop ,  Andrew L. De Kock ,  Allan C. Shuros

IPC: A61B18/14 ,  A61B18/12

Abstract: Disclosed herein are apparatus, systems, and methods for ablating tissue in a patient by electroporation. Embodiments generally include an ablation catheter having a hand, a shaft, and an electroporation electrode arrangement. The shaft has a distal end and defines a longitudinal axis of the ablation catheter. The electroporation electrode arrangement is at the distal end of the shaft and is configured to generate a multidirectional electric field when at least one pulse sequence is delivered thereto. The multidirectional electric field includes at least two of the following directions relative to the longitudinal axis: generally axial, circumferential, and transverse. The electroporation electrode arrangement is configured to operatively couple to an electroporation generator that is configured to generate the at least one pulse sequence and is configured to receive the at least one pulse sequence from the electroporation generator.

公开(公告)号：US12268437B2

公开(公告)日：2025-04-08

申请号：US17381953

申请日：2021-07-21

Applicant: Boston Scientific Scimed Inc

Inventor： Brendan E. Koop ,  Andrew L. De Kock ,  Allan C. Shuros

IPC: A61B18/00 ,  A61B18/12 ,  A61B18/14

Abstract: Disclosed herein are apparatus, systems, and methods for ablating tissue in a patient by electroporation. Embodiments generally include an ablation catheter having a hand, a shaft, and an electroporation electrode arrangement. The shaft has a distal end and defines a longitudinal axis of the ablation catheter. The electroporation electrode arrangement is at the distal end of the shaft and is configured to generate a multidirectional electric field when at least one pulse sequence is delivered thereto. The multidirectional electric field includes at least two of the following directions relative to the longitudinal axis: generally axial, circumferential, and transverse. The electroporation electrode arrangement is configured to operatively couple to an electroporation generator that is configured to generate the at least one pulse sequence and is configured to receive the at least one pulse sequence from the electroporation generator.

公开(公告)号：US20230026265A1

公开(公告)日：2023-01-26

申请号：US17383092

申请日：2021-07-22

Applicant: Boston Scientific Scimed, Inc.

Inventor： Allan C. Shuros ,  Brendan E. Koop ,  Michael S. Coe

IPC: A61B18/14 ,  A61B18/12

Abstract: At least some embodiments of the present disclosures are directed to a hybrid electroporation ablation catheter. In some embodiments, the hybrid electroporation ablation catheter comprises a catheter shaft having a proximal end and an opposite distal end and an electrode assembly extending from the distal end of the catheter shaft and the electrode assembly comprising a plurality of energy-delivering electrodes. The electrode assembly is configured to be selectively operable in a plurality of different operation modes.

公开(公告)号：US20220022954A1

公开(公告)日：2022-01-27

申请号：US17383102

申请日：2021-07-22

Applicant: Boston Scientific Scimed, Inc.

Inventor： Allan C. Shuros ,  Brendan E. Koop

IPC: A61B18/14

Abstract: At least some embodiments of the present disclosure are directed to an electroporation ablation catheter having tissue-contactless electrodes. In some embodiments, the electroporation ablation catheter comprises a catheter shaft defining a longitudinal axis and having a proximal end and a distal end; and an electrode assembly extending from the distal end of the catheter shaft, the electrode assembly configured to assume a first collapsed state and a second expanded state. In some cases, the electrode assembly includes an expandable component, and a plurality of electrodes disposed on the expandable component, where in the second state the expandable component have portions configured to protrude from adjacent electrodes.

公开(公告)号：US20220015826A1

公开(公告)日：2022-01-20

申请号：US17378219

申请日：2021-07-16

Applicant: Boston Scientific Scimed Inc.

Inventor： Brendan E. Koop ,  Andrew L. De Kock ,  Allan C. Shuros ,  Edward J. Maierhofer

IPC: A61B18/14 ,  A61M25/00

Abstract: A catheter for focal cardiac ablation by irreversible electroporation includes a flexible catheter body, a plurality of tines disposed at a distal end of the catheter body, a flexible shaft, a return electrode, and an electrical conductor. The plurality of tines are formed of an electrically conductive material and configured to deploy from a lumen at the distal end of the catheter body. Each tine of the plurality of tines is configured to self-bias from a linear configuration within the lumen to a curved configuration when deployed from the lumen. The shaft is mechanically and electrically coupled to the plurality of tines. The shaft is configured to deploy the tines from the lumen when the shaft is moved toward the distal end of the catheter body. The return electrode is disposed on an outer surface of the catheter body. The electrical conductor is electrically coupled to the return electrode.

公开(公告)号：US20240197394A1

公开(公告)日：2024-06-20

申请号：US18510178

申请日：2023-11-15

Applicant: Boston Scientific Scimed, Inc.

Inventor： Nathan P. Hagstrom ,  Brian Soltis ,  Edward J. Maierhofer ,  Andrew L. DeKock ,  Brendan E. Koop

IPC: A61B18/14

CPC classification number: A61B18/1492 ,  A61B2018/00577

Abstract: A catheter for ablation of tissue through irreversible electroporation includes an electrode assembly comprising a flexible circuit having a distally located central flex circuit hub and a plurality of flex circuit branches extending proximally from the hub portion, each of the flex circuit branches defining, at least in part, an electrode assembly spline. The flexible circuit further includes a distal ablation electrode including an ablation electrode hub portion, and a plurality of radial segments integrally formed with the ablation electrode hub portion, each of the radial segments extending proximally along a portion of a respective one of the flex circuit branches and terminating in a proximal end, a plurality of proximal ablation electrodes, each of the proximal ablation electrodes located on a respective one of the flex circuit branches and having a distal end spaced from the proximal end of the adjacent radial segment of the distal ablation electrode.

公开(公告)号：US20220378502A1

公开(公告)日：2022-12-01

申请号：US17825456

申请日：2022-05-26

Applicant: Boston Scientific Scimed Inc.

Inventor： Brendan E. Koop ,  Andrew L. De Kock

IPC: A61B18/14

Abstract: Various aspects of the present disclosure are directed towards apparatuses, systems and methods that may include an electroporation ablation device. The electroporation ablation device may include a shaft defining a longitudinal axis and an electrode assembly including a first pair of electrodes having a first electrode and a second electrode, and a second pair of electrodes disposed adjacent to the first pair of electrodes and having a third and a fourth electrode. In some embodiments, the first electrode has a first edge portion, and a first side view of the first edge portion along the longitudinal axis is rounded at a first corner.

公开(公告)号：US20220022953A1

公开(公告)日：2022-01-27

申请号：US17382967

申请日：2021-07-22

Applicant: Boston Scientific Scimed, Inc.

Inventor： Allan C. Shuros ,  Brendan E. Koop

IPC: A61B18/14

Abstract: At least some embodiments of the present disclosure are directed to an electroporation ablation device having a first catheter and a second catheter. The first catheter comprises one or more first electrodes and has a first surface area. The second catheter comprises one or more second electrodes and has a second surface area. When the electroporation ablation device is in operation for ablating a target tissue, the first catheter is configured to be disposed in an extracardiac location and anatomically proximate to the target tissue, the second catheter is configured to be disposed at an intracardiac location proximate to the target tissue, and the electroporation ablation device is configured to generate an electric field between the one or more first electrodes and the one or more second electrodes with electric field strength sufficient to ablate the target tissue via irreversible electroporation.