公开(公告)号：US20210060183A1

公开(公告)日：2021-03-04

申请号：US16999871

申请日：2020-08-21

Applicant: Boston Scientific Scimed Inc.

Inventor： Joseph T. Delaney, JR. ,  Kolbein K. Kolste ,  Tatyana Dyndikova

IPC: A61K49/04 ,  A61L27/52 ,  A61L27/58 ,  C08J3/24 ,  C08L101/00

Abstract: In some aspects, the present disclosure pertains to a polymer that comprises a plurality of polymer arms, wherein a first portion of the polymer arms comprise a reactive end group and wherein a second portion of the polymer arms comprise a branched end group that comprise a plurality of covalently attached diagnostic and/or therapeutic groups, which may be, for example, radiocontrast groups or radioactive groups. Other aspects pertain to a system that comprises (a) a first composition comprising such a polymer and (b) a second composition comprising a multifunctional compound that comprises reactive functional groups that are reactive with the reactive end group of the multi-arm polymer. Still other aspects pertain to a crosslinked reaction product of (a) such a polymer and (b) a multifunctional compound that comprises functional groups that are reactive with the reactive end group of the multi-arm polymer.

公开(公告)号：US12178888B2

公开(公告)日：2024-12-31

申请号：US16999871

申请日：2020-08-21

Applicant: Boston Scientific Scimed Inc.

Inventor： Joseph T. Delaney, Jr. ,  Kolbein K. Kolste ,  Tatyana Dyndikova

IPC: A61K49/04 ,  A61L27/52 ,  A61L27/58 ,  C08J3/24 ,  C08L39/06 ,  C08L71/02 ,  C08L101/00

Abstract: In some aspects, the present disclosure pertains to a polymer that comprises a plurality of polymer arms, wherein a first portion of the polymer arms comprise a reactive end group and wherein a second portion of the polymer arms comprise a branched end group that comprise a plurality of covalently attached diagnostic and/or therapeutic groups, which may be, for example, radiocontrast groups or radioactive groups. Other aspects pertain to a system that comprises (a) a first composition comprising such a polymer and (b) a second composition comprising a multifunctional compound that comprises reactive functional groups that are reactive with the reactive end group of the multi-arm polymer. Still other aspects pertain to a crosslinked reaction product of (a) such a polymer and (b) a multifunctional compound that comprises functional groups that are reactive with the reactive end group of the multi-arm polymer.

公开(公告)号：US20250073356A1

公开(公告)日：2025-03-06

申请号：US18954294

申请日：2024-11-20

Applicant: Boston Scientific Scimed Inc.

Inventor： Joseph T. Delaney, JR. ,  Kolbein K. Kolste ,  Tatyana Dyndikova

IPC: A61K49/04 ,  A61L27/52 ,  A61L27/58 ,  C08J3/24 ,  C08L39/06 ,  C08L71/02 ,  C08L101/00

Abstract: In some aspects, the present disclosure pertains to a polymer that comprises a plurality of polymer arms, wherein a first portion of the polymer arms comprise a reactive end group and wherein a second portion of the polymer arms comprise a branched end group that comprise a plurality of covalently attached diagnostic and/or therapeutic groups, which may be, for example, radiocontrast groups or radioactive groups. Other aspects pertain to a system that comprises (a) a first composition comprising such a polymer and (b) a second composition comprising a multifunctional compound that comprises reactive functional groups that are reactive with the reactive end group of the multi-arm polymer. Still other aspects pertain to a crosslinked reaction product of (a) such a polymer and (b) a multifunctional compound that comprises functional groups that are reactive with the reactive end group of the multi-arm polymer.

公开(公告)号：US20210062004A1

公开(公告)日：2021-03-04

申请号：US16999841

申请日：2020-08-21

Applicant: Boston Scientific Scimed Inc.

Inventor： Joseph T. Delaney, JR. ,  Kolbein K. Kolste ,  Tatyana Dyndikova

IPC: C08L101/00 ,  C08J3/24

Abstract: In some aspects, the present disclosure pertains to a polymer that comprises a plurality of polymeric arms, wherein a first portion of the polymeric arms each comprises a reactive end group and wherein a second portion of the polymeric arms each comprises a radiopaque aromatic moiety comprising a monocyclic or multicyclic aromatic structure having a plurality of radiopaque functional groups and a plurality of hydrophilic functional groups. In some aspects, the present disclosure pertains to systems comprising (a) a first composition comprising such a radiopaque polymer and (b) a second composition comprising a multifunctional compound that comprises reactive functional groups that are reactive with the reactive end group. In some aspects, the present disclosure pertains to crosslinked reaction products of (a) such a radiopaque polymer and (b) a multifunctional compound that comprises reactive functional groups that are reactive with the reactive end group.