公开(公告)号：US20210060183A1

公开(公告)日：2021-03-04

申请号：US16999871

申请日：2020-08-21

Applicant: Boston Scientific Scimed Inc.

Inventor： Joseph T. Delaney, JR. ,  Kolbein K. Kolste ,  Tatyana Dyndikova

IPC: A61K49/04 ,  A61L27/52 ,  A61L27/58 ,  C08J3/24 ,  C08L101/00

Abstract: In some aspects, the present disclosure pertains to a polymer that comprises a plurality of polymer arms, wherein a first portion of the polymer arms comprise a reactive end group and wherein a second portion of the polymer arms comprise a branched end group that comprise a plurality of covalently attached diagnostic and/or therapeutic groups, which may be, for example, radiocontrast groups or radioactive groups. Other aspects pertain to a system that comprises (a) a first composition comprising such a polymer and (b) a second composition comprising a multifunctional compound that comprises reactive functional groups that are reactive with the reactive end group of the multi-arm polymer. Still other aspects pertain to a crosslinked reaction product of (a) such a polymer and (b) a multifunctional compound that comprises functional groups that are reactive with the reactive end group of the multi-arm polymer.

公开(公告)号：US20190275178A1

公开(公告)日：2019-09-12

申请号：US16276174

申请日：2019-02-14

Applicant: Boston Scientific Scimed, Inc.

Inventor： Joseph Thomas Delaney ,  Douglas Dean Pagoria ,  Richard Lee Tadsen ,  Andrew J. Ro ,  Joel T. Eggert ,  Douglas Pennington ,  Paul Sorajja ,  Sarah Melissa Gruba ,  Tatyana Dyndikova

IPC: A61K49/04

Abstract: An imaging contrast composition comprising an iodinated contrast agent and a ligand secured to the iodinated contrast agent is disclosed, the ligand comprising a reactive group capable of bonding to a capture substrate. A method of removing iodinated radiocontrast agents from a patient is disclosed, the method comprising providing an iodinated radiocontrast agent containing a reactive group; providing a capture substrate for insertion into a patient's bloodstream; administering the iodinated radiocontrast agent to the patient; conducting procedure CT scan or procedure using fluoroscopy; and sequestering the iodinated radiocontrast agent on the capture substrate.

公开(公告)号：US20250059323A1

公开(公告)日：2025-02-20

申请号：US18939927

申请日：2024-11-07

Applicant: Boston Scientific Scimed Inc.

Inventor： Joseph Thomas Delaney, JR. ,  Carey Rehder ,  Tatyana Dyndikova ,  John Kummailil

IPC: C08G63/91 ,  C08G73/02 ,  C08K5/00

Abstract: In some aspects, the present disclosure pertains to multi-arm polymers that comprise a core, a plurality of polymer segments having a first end that is covalently attached to the core and a second end comprising a moiety that comprises a reactive group, wherein the polymer segments comprise one or more free-radical-polymerizable monomers. In some aspects, systems are provided that comprise a first composition comprising such a multi-arm polymer and a second composition comprising a multifunctional compound that comprises functional groups that are reactive with the reactive groups of the multi-arm polymer. In some aspects, systems are provided that comprise crosslinked reaction products of such a multi-arm polymer and such a multifunctional compound.

公开(公告)号：US20240117121A1

公开(公告)日：2024-04-11

申请号：US18489223

申请日：2023-10-18

Applicant: Boston Scientific Scimed Inc.

Inventor： Joseph T. Delaney, JR. ,  Paul V. Grosso ,  John Kummailil ,  Tatyana Dyndikova ,  Carey Rehder

IPC: C08G77/04 ,  C08F283/12

CPC classification number: C08G77/045 ,  C08F283/12 ,  A61L27/52

Abstract: In some aspects, the present disclosure pertains to multi-arm polymers that comprise a core and a plurality of polymer segments having a first end that is covalently attached to the core and (a) a second end comprising a moiety that comprises a reactive end group, wherein the polymer segments comprise one or more hydrophilic aprotic NMP-polymerizable monomers, and wherein the reactive multi-arm polymer comprises nitroxide radicals or (b) a second end comprising a moiety that comprises an alkoxyamine group, wherein the core is a polyol residue, and wherein the polymer segments comprise one or more NMP-polymerizable monomers. In some aspects, the present disclosure pertains to a multifunctional alkoxyamine molecule comprising a core and a plurality of alkoxyamine groups covalently attached to the core, wherein the core is a polyol residue.

公开(公告)号：US20220243009A1

公开(公告)日：2022-08-04

申请号：US17724892

申请日：2022-04-20

Applicant: Boston Scientific Scimed Inc.

Inventor： Joseph Thomas Delaney, JR. ,  Carey Rehder ,  Tatyana Dyndikova ,  John Kummailil

IPC: C08G63/91 ,  C08G73/02 ,  C08K5/00

Abstract: In some aspects, the present disclosure pertains to multi-arm polymers that comprise a core, a plurality of polymer segments having a first end that is covalently attached to the core and a second end comprising a moiety that comprises a reactive group, wherein the polymer segments comprise one or more free-radical-polymerizable monomers. In some aspects, systems are provided that comprise a first composition comprising such a multi-arm polymer and a second composition comprising a multifunctional compound that comprises functional groups that are reactive with the reactive groups of the multi-arm polymer. In some aspects, systems are provided that comprise crosslinked reaction products of such a multi-arm polymer and such a multifunctional compound.

公开(公告)号：US11213596B2

公开(公告)日：2022-01-04

申请号：US16276174

申请日：2019-02-14

Applicant: Boston Scientific Scimed, Inc.

Inventor： Joseph Thomas Delaney, Jr. ,  Douglas Dean Pagoria ,  Richard Lee Tadsen ,  Andrew J. Ro ,  Joel T. Eggert ,  Douglas Pennington ,  Paul Sorajja ,  Sarah Melissa Gruba ,  Tatyana Dyndikova

IPC: A61K49/04 ,  A61F2/01

Abstract: An imaging contrast composition comprising an iodinated contrast agent and a ligand secured to the iodinated contrast agent is disclosed, the ligand comprising a reactive group capable of bonding to a capture substrate. A method of removing iodinated radiocontrast agents from a patient is disclosed, the method comprising providing an iodinated radiocontrast agent containing a reactive group; providing a capture substrate for insertion into a patient's bloodstream; administering the iodinated radiocontrast agent to the patient; conducting procedure CT scan or procedure using fluoroscopy; and sequestering the iodinated radiocontrast agent on the capture substrate.

公开(公告)号：US20250073356A1

公开(公告)日：2025-03-06

申请号：US18954294

申请日：2024-11-20

Applicant: Boston Scientific Scimed Inc.

Inventor： Joseph T. Delaney, JR. ,  Kolbein K. Kolste ,  Tatyana Dyndikova

IPC: A61K49/04 ,  A61L27/52 ,  A61L27/58 ,  C08J3/24 ,  C08L39/06 ,  C08L71/02 ,  C08L101/00

Abstract: In some aspects, the present disclosure pertains to a polymer that comprises a plurality of polymer arms, wherein a first portion of the polymer arms comprise a reactive end group and wherein a second portion of the polymer arms comprise a branched end group that comprise a plurality of covalently attached diagnostic and/or therapeutic groups, which may be, for example, radiocontrast groups or radioactive groups. Other aspects pertain to a system that comprises (a) a first composition comprising such a polymer and (b) a second composition comprising a multifunctional compound that comprises reactive functional groups that are reactive with the reactive end group of the multi-arm polymer. Still other aspects pertain to a crosslinked reaction product of (a) such a polymer and (b) a multifunctional compound that comprises functional groups that are reactive with the reactive end group of the multi-arm polymer.

公开(公告)号：US20240307588A1

公开(公告)日：2024-09-19

申请号：US18675481

申请日：2024-05-28

Applicant: Boston Scientific Scimed, Inc.

Inventor： Joseph T. Delaney, JR. ,  Mark W. Boden ,  John Murphy ,  Viktoria Molnar ,  Tatyana Dyndikova ,  Allison Zipp ,  Kolbein K Kolste

IPC: A61L27/16 ,  A61L27/18 ,  A61L27/38 ,  A61L27/50

CPC classification number: A61L27/16 ,  A61L27/18 ,  A61L27/3839 ,  A61L27/50

Abstract: Described herein are injectable in vivo crosslinking materials for use as soft tissue filler comprising (a) a reactive multi-arm polymer that comprises a plurality of hydrophilic polymeric arms, at least a portion of the hydrophilic polymeric arms comprising one or more reactive end groups and (b) a multifunctional compound that comprises functional groups that are reactive with the reactive end groups of the reactive multi-arm polymer. Also described herein are systems and methods that are based on such materials.

公开(公告)号：US20240026081A1

公开(公告)日：2024-01-25

申请号：US18475397

申请日：2023-09-27

Applicant: Boston Scientific Scimed Inc.

Inventor： Joseph T. Delaney, JR. ,  Paul V. Grosso ,  John Kummailil ,  Tatyana Dyndikova ,  Carey Rehder

IPC: C08G73/02 ,  C08J3/24

CPC classification number: C08G73/0233 ,  C08J3/24 ,  A61L27/52

Abstract: In some aspects, the present disclosure pertains to a multi-arm polymer comprising a core and a plurality of polyoxazoline segments (or arms) having a first end that is covalently attached to the core and a second end comprising a moiety that comprises a reactive group. In some aspects, systems are provided that comprise a first composition comprising such a multi-arm polymer and a second composition comprising a multifunctional compound that comprises functional groups that are reactive with the reactive groups of the multi-arm polymer. In some aspects, systems are provided that comprise crosslinked reaction products of such a multi-arm polymer and such a multifunctional compound.

公开(公告)号：US20210062004A1

公开(公告)日：2021-03-04

申请号：US16999841

申请日：2020-08-21

Applicant: Boston Scientific Scimed Inc.

Inventor： Joseph T. Delaney, JR. ,  Kolbein K. Kolste ,  Tatyana Dyndikova

IPC: C08L101/00 ,  C08J3/24

Abstract: In some aspects, the present disclosure pertains to a polymer that comprises a plurality of polymeric arms, wherein a first portion of the polymeric arms each comprises a reactive end group and wherein a second portion of the polymeric arms each comprises a radiopaque aromatic moiety comprising a monocyclic or multicyclic aromatic structure having a plurality of radiopaque functional groups and a plurality of hydrophilic functional groups. In some aspects, the present disclosure pertains to systems comprising (a) a first composition comprising such a radiopaque polymer and (b) a second composition comprising a multifunctional compound that comprises reactive functional groups that are reactive with the reactive end group. In some aspects, the present disclosure pertains to crosslinked reaction products of (a) such a radiopaque polymer and (b) a multifunctional compound that comprises reactive functional groups that are reactive with the reactive end group.