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公开(公告)号：US07135286B2
公开(公告)日：2006-11-14
申请号：US10107508
申请日：2002-03-26
IPC分类号： C12Q1/68
摘要： Improved pharmaceutical and diagnostic business systems and methods are disclosed. One or more genomes are scanned for single nucleotide polymorphisms. The polymorphisms are assigned to haplotype blocks, and representative SNPs from the haplotype blocks are used in association studies for pharmaceutical and diagnostic development.
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公开(公告)号：US06955883B2
公开(公告)日：2005-10-18
申请号：US10402839
申请日：2003-03-26
IPC分类号： C12N15/09 , A61K31/00 , A61K31/711 , A61K38/00 , A61K39/395 , A61K48/00 , A61P3/10 , A61P31/04 , A61P35/00 , A61P37/02 , C12Q1/68 , G01N20060101 , G01N33/48 , G01N33/50 , G06F19/00 , G06Q50/22 , G06Q50/24
摘要： Improved life sciences business systems and methods are disclosed. One or more genomes are scanned for single nucleotide polymorphisms. The polymorphisms are assigned to haplotype blocks, and representative SNPs from the haplotype blocks are used in association studies for pharmaceutical and diagnostic developments.
摘要翻译： 披露了改进的生命科学业务系统和方法。 一个或多个基因组扫描单核苷酸多态性。 将多态性分配给单倍型区段，并且来自单倍型区段的代表性SNP用于药物和诊断发展的关联研究。
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公开(公告)号：US06897025B2
公开(公告)日：2005-05-24
申请号：US10042819
申请日：2002-01-07
申请人： David R. Cox , Bradley A. Margus , Nila Patil
发明人： David R. Cox , Bradley A. Margus , Nila Patil
CPC分类号： C12Q1/6827 , C12Q2565/125 , C12Q2565/501
摘要： Improved systems and methods for performing genetic analyses. Full genomic DNA scans are performed on the genetic DNA from a plurality of individuals to identify genetic variants. For those variants, but not based on a full genetic DNA scan, the variants alone are scanned in additional individuals to identify blocks of the variants that tend to be inherited together.
摘要翻译： 改进的用于进行遗传分析的系统和方法。 对来自多个个体的遗传DNA进行全基因组DNA扫描，以鉴定遗传变异。 对于这些变体，但不是基于完整的基因DNA扫描，单独的变体被扫描在另外的个体中以鉴定易于一起遗传的变体块。
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公开(公告)号：US20090006128A1
公开(公告)日：2009-01-01
申请号：US11824943
申请日：2007-07-03
申请人： Bradley A. Margus , David A. Cox
发明人： Bradley A. Margus , David A. Cox
摘要： Improved life sciences business systems and methods are disclosed. One or more genomes are scanned for single nucleotide polymorphisms. The polymorphisms are used in association studies for pharmaceutical and diagnostic developments. In certain embodiments, an association study comprises both genotyping of these polymorphisms and resequencing of genomic regions that contain polymorphisms associated with a phenotypic state of interest.
摘要翻译： 披露了改进的生命科学业务系统和方法。 一个或多个基因组扫描单核苷酸多态性。 多态性用于药物和诊断发展的关联研究。 在某些实施方案中，关联研究包括这些多态性的基因分型和包含与感兴趣的表型状态相关的多态性的基因组区域的重新序列。
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