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    Heterocyclic sulfonamides
    10.
    发明授权
    Heterocyclic sulfonamides 有权
    杂环磺酰胺

    公开(公告)号：US08101620B2

    公开(公告)日：2012-01-24

    申请号：US13008432

    申请日：2011-01-18

    申请人： Bradley Paul Morgan ,  Fady Malik ,  Erica Anne Kraynack ,  Alexander Ramon Muci ,  Xiangping Qian ,  David J. Morgans, Jr.

    发明人： Bradley Paul Morgan ,  Fady Malik ,  Erica Anne Kraynack ,  Alexander Ramon Muci ,  Xiangping Qian ,  David J. Morgans, Jr.

    IPC分类号： A61K31/4965 ,  A61K31/41

    CPC分类号： C07D295/26 ,  C07D207/14 ,  C07D213/75 ,  C07D233/88 ,  C07D257/06 ,  C07D261/14 ,  C07D263/48 ,  C07D277/46 ,  C07D285/135 ,  C07D295/18 ,  C07D403/12

    摘要： Provided is a compound of the following formula: wherein: R3 is an aryl or heteroaryl group, which is optionally substituted with a halogen, lower alkoxy, aryl or heteroaryl group; R4 is halogen; R5 is hydrogen, halogen, hydroxy, or lower alkyl; R6 and R7 are independently selected from hydrogen, halogen, hydroxy, and lower alkyl; and R8 is hydrogen, alkyl, halogen, hydroxy, alkoxy, alkylenedioxy, carboxy, acyloxy, alkoxycarbonyl, alkoxycarbonylamino, alkylcarbonylamino, aminocarbonyl, aminocarbonylamino, cyano, acyl, oxo, nitro, amino, sulfanyl, sulfinyl, sulfonyl, aminosulfonyl, amidino, phenyl, benzyl, heteroaryl, heterocyclyl, aryloxy, arallkoxy, heteroaryloxy, or heteroaralkoxy, wherein the amino(s) in the alkoxycarbonylamino, alkylcarbonylamino, aminocarbonyl, aminocarbonylamino, amino, or aminosulfonyl is optionally substituted with alkyl; or a pharmaceutically acceptable salt thereof.

    摘要翻译： 本发明提供下式的化合物：其中：R3是芳基或杂芳基，其任选被卤素，低级烷氧基，芳基或杂芳基取代; R4是卤素; R5是氢，卤素，羟基或低级烷基; R6和R7独立地选自氢，卤素，羟基和低级烷基; 氨基羰基，氨基羰基氨基，氰基，酰基，氧代，硝基，氨基，硫烷基，亚磺酰基，磺酰基，氨基磺酰基，脒基，苯基 烷氧基羰基氨基，烷基羰基氨基，氨基羰基，氨基羰基氨基，氨基或氨基磺酰基中的氨基任选被烷基取代; 或其药学上可接受的盐。