-
公开(公告)号:US20080275022A1
公开(公告)日:2008-11-06
申请号:US11569918
申请日:2005-06-14
申请人: Brian Aquila , Les Dakin , Jayachandran Ezhuthachan , John Lee , Paul Lyne , Timothy Pontz
发明人: Brian Aquila , Les Dakin , Jayachandran Ezhuthachan , John Lee , Paul Lyne , Timothy Pontz
IPC分类号: A61K31/517 , C07D239/88 , C07D413/02 , A61K31/5377 , C07D403/02 , A61P35/00
CPC分类号: C07D239/91 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/12 , C07D409/12 , C07D417/12
摘要: The invention relates to chemical compounds of the formula (I): or pharmaceutically acceptable salts thereof, which possess B Raf inhibitory activity and are accordingly useful for their anti cancer activity and thus in methods of treatment of the human or animal body. The invention also relates to processes for the manufacture of said chemical compounds, to pharmaceutical compositions containing them and to their use in the manufacture of medicaments of use in the production of an anti-cancer effect in a warm blooded animal such as man.
摘要翻译: 本发明涉及具有B Raf抑制活性的式(I)化合物或其药学上可接受的盐,因此可用于其抗癌活性,因此可用于治疗人或动物体的方法。 本发明还涉及制备所述化合物的方法,含有它们的药物组合物及其在制备用于在温血动物如人中产生抗癌作用的药物中的用途。
-
公开(公告)号:US20080207616A1
公开(公告)日:2008-08-28
申请号:US11577132
申请日:2005-10-13
申请人: Brian Aquila , Les Dakin , Tracy Deegan , Stephanos Ioannidis , Stephen Lee , Paul Lyne , Timothy Pontz , Mei Su
发明人: Brian Aquila , Les Dakin , Tracy Deegan , Stephanos Ioannidis , Stephen Lee , Paul Lyne , Timothy Pontz , Mei Su
IPC分类号: A61K31/498 , C07D413/12 , C07D403/12 , C07D401/12 , A61K31/5377 , A61P35/00 , C07D407/12 , C07D409/12
CPC分类号: C07D409/14 , C07D241/42 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12
摘要: The invention relates to chemical compounds of the formula (I) or pharmaceutically acceptable salts thereof, which possess B Raf inhibitory activity and are accordingly useful for their anti cancer activity and thus in methods of treatment of the human or animal body. The invention also relates to processes for the manufacture of said chemical compounds, to pharmaceutical compositions containing them and to their use in the manufacture of medicaments of use in the production of an anti-cancer effect in a warm blooded animal such as man.
摘要翻译: 本发明涉及具有B Raf抑制活性的式(I)化合物或其药学上可接受的盐,因此可用于其抗癌活性,因此可用于治疗人或动物体的方法。 本发明还涉及制备所述化合物的方法,含有它们的药物组合物及其在制备用于在温血动物如人中产生抗癌作用的药物中的用途。
-