公开(公告)号：US07560688B2

公开(公告)日：2009-07-14

申请号：US11582198

申请日：2006-10-16

申请人： Brian H. Clowers ,  Herbert H. Hill, Jr. ,  Prabha Dwivedi ,  Matthew Pollard

发明人： Brian H. Clowers ,  Herbert H. Hill, Jr. ,  Prabha Dwivedi ,  Matthew Pollard

IPC分类号： H01J49/00

CPC分类号： H01J49/02 ,  G01N27/622 ,  H01J49/004

摘要： Particular aspects provide novel methods for analysis of ion populations, the methods comprising filtering and selecting an ion population using a low-field dual-gate ion mobility spectrometer comprising a drift tube, the spectrometer operating at a pressure of at least 100 Torr, to provide mobility-selected ions. Certain aspects comprise: (i) subsequently accumulating the low-field selected ions in an ion trap (e.g., an MS ion trap) and mass spectrometry analysis; (ii) introducing the low-field selected ions into a high-field ion mobility spectrometer for separating thereby (optionally followed by mass spectrometry); and (iii) introducing the low-field selected ions into an ion trap mass spectrometer, and subsequently into a second low-field ion mobility spectrometer (e.g., a non-dual gate spectrometer operating at less than about 100 Torr). Additional aspects provide novel apparatus and combination thereof for performing the disclosed methods.

摘要翻译： 具体方面提供用于分析离子群体的新方法，所述方法包括使用包含漂移管的低场双栅离子迁移谱仪来过滤和选择离子群，所述漂移管在至少100托的压力下操作，以提供 迁移率选择离子 某些方面包括：（i）随后在离子阱（例如，MS离子阱）中积聚低场选择的离子和质谱分析; （ii）将低场选择的离子引入用于分离的高场离子迁移谱仪（任选地随后进行质谱）; 和（iii）将低场选择的离子引入离子阱质谱仪中，随后进入第二低场离子迁移谱仪（例如，操作在小于约100托的非双栅光谱仪）。 另外的方面提供了用于执行所公开的方法的新颖的装置及其组合。

公开(公告)号：US20070158543A1

公开(公告)日：2007-07-12

申请号：US11582198

申请日：2006-10-16

申请人： Brian Clowers ,  Herbert Hill ,  Prabha Dwivedi ,  Matthew Pollard

发明人： Brian Clowers ,  Herbert Hill ,  Prabha Dwivedi ,  Matthew Pollard

IPC分类号： B01D59/44

CPC分类号： H01J49/02 ,  G01N27/622 ,  H01J49/004

摘要： Particular aspects provide novel methods for analysis of ion populations, the methods comprising filtering and selecting an ion population using a low-field dual-gate ion mobility spectrometer comprising a drift tube, the spectrometer operating at a pressure of at least 100 Torr, to provide mobility-selected ions. Certain aspects comprise: (i) subsequently accumulating the low-field selected ions in an ion trap (e.g., an MS ion trap) and mass spectrometry analysis; (ii) introducing the low-field selected ions into a high-field ion mobility spectrometer for separating thereby (optionally followed by mass spectrometry); and (iii) introducing the low-field selected ions into an ion trap mass spectrometer, and subsequently into a second low-field ion mobility spectrometer (e.g., a non-dual gate spectrometer operating at less than about 100 Torr). Additional aspects provide novel apparatus and combination thereof for performing the disclosed methods.

摘要翻译： 具体方面提供用于分析离子群体的新方法，所述方法包括使用包含漂移管的低场双栅离子迁移谱仪来过滤和选择离子群，所述漂移管在至少100托的压力下操作，以提供 迁移率选择离子 某些方面包括：（i）随后在离子阱（例如，MS离子阱）中积聚低场选择的离子和质谱分析; （ii）将低场选择的离子引入用于分离的高场离子迁移谱仪（任选地随后进行质谱）; 和（iii）将低场选择的离子引入离子阱质谱仪中，随后进入第二低场离子迁移谱仪（例如，操作在小于约100托的非双栅光谱仪）。 另外的方面提供了用于执行所公开的方法的新颖的装置及其组合。