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公开(公告)号：US08796261B2
公开(公告)日：2014-08-05
申请号：US13309646
申请日：2011-12-02
申请人： Brian K. Albrecht , James E. Audia , Alexandre Côté , Victor S. Gehling , Jean-Christophe Harmange , Michael C. Hewitt , Yves Leblanc , Christopher G. Nasveschuk , Alexander M. Taylor , Rishi G. Vaswani
发明人： Brian K. Albrecht , James E. Audia , Alexandre Côté , Victor S. Gehling , Jean-Christophe Harmange , Michael C. Hewitt , Yves Leblanc , Christopher G. Nasveschuk , Alexander M. Taylor , Rishi G. Vaswani
IPC分类号： A61K31/55 , C07D498/04 , C07D498/20 , C07K14/47 , C07D498/14 , C07D498/22
CPC分类号： C07D498/04 , A61K31/424 , A61K31/55 , C07D498/14 , C07D498/20 , C07D498/22 , C07K14/4702
摘要： The present invention relates to compounds useful as inhibitors of bromodomain-containing proteins. The invention also provides pharmaceutically acceptable compositions comprising compounds of the present invention and methods of using said compositions in the treatment of various disorders.
摘要翻译： 本发明涉及可用作含溴结构域蛋白质的抑制剂的化合物。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用所述组合物治疗各种疾病的方法。
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公开(公告)号：US20140371206A1
公开(公告)日：2014-12-18
申请号：US14313148
申请日：2014-06-24
申请人： Brian K. Albrecht , James Edmund Audia , Alexandre Côté , Victor S. Gehling , Jean-Christophe Harmange , Michael Charles Hewitt , Yves Leblanc , Christopher G. Nasveschuk , Alexander M. Taylor , Rishi G. Vaswani
发明人： Brian K. Albrecht , James Edmund Audia , Alexandre Côté , Victor S. Gehling , Jean-Christophe Harmange , Michael Charles Hewitt , Yves Leblanc , Christopher G. Nasveschuk , Alexander M. Taylor , Rishi G. Vaswani
IPC分类号： C07D498/04
CPC分类号： C07D498/04 , A61K31/424 , A61K31/55 , C07D498/14 , C07D498/20 , C07D498/22 , C07K14/4702
摘要： The present invention relates to compounds useful as inhibitors of bromodomain-containing proteins. The invention also provides pharmaceutically acceptable compositions comprising compounds of the present invention and methods of using said compositions in the treatment of various disorders.
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公开(公告)号：US09249161B2
公开(公告)日：2016-02-02
申请号：US13990906
申请日：2011-12-02
申请人： Brian K. Albrecht , James Edmund Audia , Alexandre Côté , Victor S. Gehling , Jean-Christophe Harmange , Michael Charles Hewitt , Christopher G. Nasveschuk , Alexander M. Taylor , Rishi G. Vaswani
发明人： Brian K. Albrecht , James Edmund Audia , Alexandre Côté , Victor S. Gehling , Jean-Christophe Harmange , Michael Charles Hewitt , Christopher G. Nasveschuk , Alexander M. Taylor , Rishi G. Vaswani
IPC分类号： C07D513/20 , C07D498/10 , C07D487/10 , C07D495/22 , C07D495/14 , C07D495/20 , C07D498/04 , C07D498/14 , C07D513/14
CPC分类号： C07D513/20 , C07D487/10 , C07D495/14 , C07D495/20 , C07D495/22 , C07D498/04 , C07D498/10 , C07D498/14 , C07D513/14
摘要： The present invention relates to compounds useful as inhibitors of bromodomain-containing proteins. The invention also provides pharmaceutically acceptable compositions comprising compounds of the present invention and methods of using said compositions in the treatment of various disorders.
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公开(公告)号：US08754050B2
公开(公告)日：2014-06-17
申请号：US13700373
申请日：2011-05-26
CPC分类号： C07K11/02 , A61K31/425 , A61K38/005 , A61K38/15 , A61K39/3955 , A61K45/06 , C07K5/0821 , C07K11/00
摘要： The present invention provides a novel macrocyclic compound of general Formula (I) having histone deacetylase (HDAC) inhibitory activity, a pharmaceutical composition comprising the compound, and a method useful to treat diseases using the compound.
摘要翻译： 本发明提供了具有组蛋白脱乙酰酶（HDAC）抑制活性的通式（I）的新型大环化合物，包含该化合物的药物组合物和可用于使用该化合物治疗疾病的方法。
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公开(公告)号：US20130203681A1
公开(公告)日：2013-08-08
申请号：US13700373
申请日：2011-05-26
CPC分类号： C07K11/02 , A61K31/425 , A61K38/005 , A61K38/15 , A61K39/3955 , A61K45/06 , C07K5/0821 , C07K11/00
摘要： The present invention provides a novel macrocyclic compound of general Formula (I) having histone deacetylase (HDAC) inhibitory activity, a pharmaceutical composition comprising the compound, and a method useful to treat diseases using the compound.
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