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    Method and apparatus for conversion of multiple analyte cation types to a single analyte anion type via ion/ion charge inversion
    3.
    发明授权
    Method and apparatus for conversion of multiple analyte cation types to a single analyte anion type via ion/ion charge inversion 有权
    通过离子/离子电荷反转将多种分析物阳离子类型转化成单一分析物阴离子型的方法和装置

    公开(公告)号：US08927295B2

    公开(公告)日：2015-01-06

    申请号：US12874819

    申请日：2010-09-02

    申请人： Kerry M. Hassell ,  Scott A. McLuckey ,  Yves Leblanc

    发明人： Kerry M. Hassell ,  Scott A. McLuckey ,  Yves Leblanc

    IPC分类号： G01N24/00 ,  H01J49/00

    CPC分类号： H01J49/0072 ,  H01J49/004 ,  H01J49/165 ,  Y10T436/24

    摘要： An apparatus and method for a sample using a mass spectrometer is described, including, generating ions of a first polarity from an analyte using electrospray ionization; generating ions of a second polarity from a reagent; injecting the ions of the first polarity and ions of the second polarity in sequence into a chamber of the mass spectrometer such that the ions of the first polarity and the ions of the second polarity interact in the chamber to form analyte ions having the second polarity; and, analyzing the mass spectrum of the analyte ions of the second polarity. A reagent such as a polyamidomine is selected to preferentially yield analyte ions of the second polarity having a desired mass-to-charge ratio.

    摘要翻译： 描述了使用质谱仪的样品的装置和方法，包括使用电喷雾离子化从分析物产生具有第一极性的离子; 从试剂产生第二极性的离子; 将第一极性的离子和第二极性的离子依次注入到质谱仪的室中，使得第一极性的离子和第二极性的离子在室中相互作用以形成具有第二极性的分析物离子; 并分析第二极性的分析物离子的质谱。 选择诸如聚酰胺胺的试剂优先产生具有所需质荷比的具有第二极性的分析物离子。