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公开(公告)号：US06426071B2
公开(公告)日：2002-07-30
申请号：US09877759
申请日：2001-06-08
IPC分类号： A61K3836
CPC分类号： A61K38/4866 , C12N9/6464 , C12Y304/21069 , Y10S514/802
摘要： A method of treatment for patients with vascular occlusion and thromboembolic disorders including the acquired disease state of thrombotic stroke, by administering activated protein C. The administration of aPC provides a highly selective therapeutic agent with a low potential for causing bleeding complications. The administration of aPC is beneficial in preventing the local extension of the microvascular and macrovascular occluding arterial thrombus, thereby reducing the neurological deficit resulting from the stroke.
摘要翻译： 通过施用活化的蛋白C，治疗血管闭塞和血栓栓塞障碍的患者的方法，包括所获得的血栓性中风的疾病状态.APC的施用提供了具有低出血并发症潜力的高选择性治疗剂。 aPC的施用有利于预防微血管和大血管闭塞性动脉血栓的局部延伸，从而减少由中风引起的神经功能缺损。
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公开(公告)号：US06268337B1
公开(公告)日：2001-07-31
申请号：US09465076
申请日：1999-12-16
IPC分类号： A61K3836
CPC分类号： A61K38/4866 , C12N9/6464 , C12Y304/21069 , Y10S514/802
摘要： A method of treatment for patients with vascular occlusion and thromboembolic disorders including the acquired disease state of thrombotic stroke, by administering activated protein C. The administration of aPC provides a highly selective therapeutic agent with a low potential for causing bleeding complications. The administration of aPC is beneficial in preventing the local extension of the microvascular and macrovascular occluding arterial thrombus, thereby reducing the neurological deficit resulting from the stroke.
摘要翻译： 通过施用活化的蛋白C，治疗血管闭塞和血栓栓塞障碍的患者的方法，包括所获得的血栓性中风的疾病状态.APC的施用提供了具有低出血并发症潜力的高选择性治疗剂。 aPC的施用有利于预防微血管和大血管闭塞性动脉血栓的局部延伸，从而减少由中风引起的神经功能缺损。
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公开(公告)号：US6037322A
公开(公告)日：2000-03-14
申请号：US161900
申请日：1998-09-28
IPC分类号： C12N15/09 , A61K20060101 , A61K38/00 , A61K38/02 , A61K38/12 , A61K38/36 , A61K38/48 , A61P7/00 , A61P7/02 , A61P11/00 , A61P15/00 , A61P17/02 , A61P31/00 , A61P31/04 , A61P41/00 , A61P43/00 , C12N20060101 , C12N9/64 , C12N15/00 , C12P21/00
CPC分类号： A61K38/4866 , C12N9/6464 , C12Y304/21069 , Y10S514/802
摘要： A method of treatment for patients with vascular occlusion and thromboembolic disorders including the acquired disease state of thrombotic stroke, by administering activated protein C. The administration of aPC provides a highly selective therapeutic agent with a low potential for causing bleeding complications. The administration of aPC is beneficial in preventing the local extension of the microvascular and macrovascular occluding arterial thrombus, thereby reducing the neurological deficit resulting from the stroke.
摘要翻译： 通过施用活化的蛋白C，治疗血管闭塞和血栓栓塞障碍的患者的方法，包括所获得的血栓性中风的疾病状态.APC的施用提供了具有低出血并发症潜力的高选择性治疗剂。 aPC的施用有利于预防微血管和大血管闭塞性动脉血栓的局部延伸，从而减少由中风引起的神经功能缺损。
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