公开(公告)号：US20230089255A1

公开(公告)日：2023-03-23

申请号：US17786442

申请日：2020-12-18

申请人： BRISTOL-MYERS SQUIBB COMPANY

发明人： Susan WEE ,  Joseph L. BENC ,  Xinyu WANG ,  Upender VELAPARTHI ,  Louis S. CHUPAK ,  Chatan P. DARNE ,  Min DING ,  Robert G. GENTLES ,  Yazhong HUANG ,  Scott W. MARTIN ,  Ivar M. MCDONALD ,  Richard E. OLSON ,  Xiaofan ZHENG ,  John S. TOKARSKI ,  Bireshwar DASGUPTA ,  Manjunatha Narayana Rao KAMBLE ,  Raju MANNOORI ,  Haslbur RAHAMAN ,  Prasada Rao JALAGAM ,  Saumya ROY ,  Gopikishan TONUKUNURU ,  Sivasudar VELAIAH ,  Jayakumar Sankara WARRIER ,  Kotha Rathnakar REDDY ,  Thiruvenkadam RAJA ,  Denise GRUNENFELDER ,  Michael WICHROSKI

IPC分类号： A61K31/519 ,  A61K31/496 ,  A61K39/395 ,  A61P35/00

摘要： Provided are inhibitors of diacylglycerol kinases (DGK) and methods for treating diseases that would benefit from the stimulation of the immune system, such as cancer and infections diseases, comprising administering a DGK inhibitor in combination with an antagonist of the PD 1/PD-L 1 axis and/or an antagonist of CTLA4.

公开(公告)号：US20240317769A1

公开(公告)日：2024-09-26

申请号：US18550234

申请日：2022-03-14

申请人： Bristol-Myers Squibb Company

发明人： Brian Edward FINK ,  Robert Joseph CHERNEY ,  Khehyong NGU ,  Upender VELAPARTHI ,  Wayne David VACCARO ,  Zheming RUAN ,  Lan-Ying QIN ,  Pravin S. SHIRUDE ,  Hasibur RAHAMAN

IPC分类号： C07D487/08 ,  A61K31/517 ,  C07D471/08 ,  C07D519/00

CPC分类号： C07D487/08 ,  A61K31/517 ,  C07D471/08 ,  C07D519/00

摘要： The present disclosure relates to KRAS inhibitors. Methods of treating cancers using the compounds are also provided.

公开(公告)号：US20240217982A1

公开(公告)日：2024-07-04

申请号：US18550237

申请日：2022-03-14

申请人： Bristol-Myers Squibb Company

发明人： Brian Edward FINK ,  Robert Joseph CHERNEY ,  Khehyong NGU ,  Upender VELAPARTHI ,  Wayne David VACCARO ,  Zheming RUAN ,  Lan-Ying QIN ,  Pravin S. SHIRUDE ,  Hasibur RAHAMAN

IPC分类号： C07D487/08 ,  C07D519/00

CPC分类号： C07D487/08 ,  C07D519/00

摘要： The present disclosure relates to KRAS inhibitors. Methods of treatment cancers using the compounds are also provided.

公开(公告)号：US20200109140A1

公开(公告)日：2020-04-09

申请号：US16452679

申请日：2019-06-26

申请人： BRISTOL-MYERS SQUIBB COMPANY

发明人： Upender VELAPARTHI ,  Louis S. Chupak ,  Chetan Padmakar Darne ,  Min Ding ,  Robert G. Gentles ,  Yazhong Huang ,  Manjunatha Narayana Rao Kamble ,  Scott W. Martin ,  Raju Mannoori ,  Ivar M. McDonald ,  Richard E. Olson ,  Hasibur Rahaman ,  Prasada Rao Jalagam ,  Saumya Roy ,  Gopikishan Tonukunuru ,  Sivasudar Velaiah ,  Jayakumar Sankara Warrier ,  Xiaofan Zheng ,  John S. Tokarski ,  Bireshwar Dasgupta ,  Kotha Rathnakar Reddy ,  Thiruvenkadam Raja

IPC分类号： C07D471/04

摘要： Disclosed are compounds of Formula (I): or a salt thereof, wherein: R1, R2, R3, R4, R5, and m are defined herein. Also disclosed are methods of using such compounds to inhibit the activity of one or both of diacylglycerol kinase alpha (DGKα) and diacylglycerol kinase zeta (DGKζ), and pharmaceutical compositions comprising such compounds. These compounds are useful in the treatment of viral infections and proliferative disorders, such as cancer.